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SMR000044769 (CID 663844) - Compound BioActivity Data
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BioActivity Outcomes:
Active(141)
 
 
Inactive(527)
 
 
Inconclusive(50)
 
 
Unspecified(2)
 
 
Top Targets:
Bcl-2 like(21)
 
 
 
7TM GPCR Srx(20)
 
 
 
7TM GPCR Srsx(18)
 
 
 
 
alkPPc(16)
 
 
Tryp SPc(12)
 
 
 
BioAssay Types:
Screening(406)
 
 
 
 
 
Confirmatory(278)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(169)
 
 
 
 
 
IC50(51)
 
 
 
 
EC50(23)
 
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 672    Data Row: 720   Total Pages: 36   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID862610]
IC50 0.2801Tumor Hsp90 Inhibitors Dose Response Confirmation [AID712, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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2
[SID862610]
IC50 0.2801Tumor Hsp90 Inhibitors Dose Response Confirmation [AID712, Type: confirmatory]90-kda heat shock protein beta HSP90 beta [Homo sapiens] [gi:4261762]
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3
[SID862610]
EC50_uM 0.5489Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction [AID435023, Type: confirmatory]LANA [Human herpesvirus 8] [gi:139472804]
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4
[SID862610]
Potency 0.631qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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5
[SID862610]
Potency 0.7943qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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6
[SID862610]
EC50_MICROM 1.11Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W. [AID1330, Type: confirmatory]Bcl-w [Homo sapiens] [gi:1572493]
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7
[SID862610]
EC50_MICROM 1.14Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. [AID1322, Type: confirmatory]bcl-xL [Homo sapiens] [gi:510901]
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8
[SID862610]
IC50 1.19MKP-3 in vitro HTS assay [AID425, Type: confirmatory]dual specificity protein phosphatase 6 [Rattus norvegicus] [gi:16758752]
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9
[SID862610]
Potency 1.5003qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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10
[SID862610]
IC50 1.717Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase [AID2754, Type: confirmatory]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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11
[SID862610]
Potency 2.21Beta amyloid ThS binding assay [AID956, Type: confirmatory]beta-amyloid peptide, A beta {N-terminal}, partial [Homo sapiens] [gi:257056]
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12
[SID862610]
IC50 3.019Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput counterscreen to identify inhibitors of TEM-1 metallo-beta-lactamase [AID2755, Type: confirmatory]Beta lactamase [Pseudomonas aeruginosa] [gi:114881106]
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13
[SID862610]
Potency 3.15137Alpha-synuclein ThS binding assay [AID937, Type: confirmatory]alpha synuclein, partial [Homo sapiens] [gi:46242542]
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14
[SID862610]
IC50 3.18Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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15
[SID862610]
IC50 3.18Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 [Homo sapiens] [gi:4502523]
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16
[SID862610]
EC50_MICROM 4.05Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2 [AID1328, Type: confirmatory]Apoptosis regulator Bcl-2 [gi:231632]
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17
[SID862610]
IC50 5.385Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase [AID2756, Type: confirmatory]metallo-beta-lactamase IMP-1 [Pseudomonas aeruginosa] [gi:27368096]
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18
[SID862610]
Potency 5.51Tau ThS binding assay [AID911, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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19
[SID862610]
EC50_uM 8.025Luminescence Cell-Free Homogenous Dose Retest to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2821, Type: confirmatory]serine/threonine-protein kinase 33 isoform a [Homo sapiens] [gi:23943882]
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20
[SID862610]
Potency 11.2202qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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