SMR000044166 (CID 663437) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(7)
 
 
Inactive(700)
 
 
Inconclusive(12)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(18)
 
 
alkPPc(16)
 
 
Bcl-2 like(11)
 
 
Tryp SPc(9)
 
 
7TM GPCR Srsx(9)
 
 
BioAssay Types:
Screening(485)
 
 
 
 
Confirmatory(210)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(131)
 
 
 
 
IC50(47)
 
 
 
EC50(13)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 720    Data Row: 720   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID862214]
IC50 16TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70 [AID786, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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2
[SID862214]
IC50 55.1High Throughput Screening Assay for Hsp70 Inhibitors [AID583, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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3
[SID862214]
 Fluorescence Polarization Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the LANA Histone H2A/H2B Interaction [AID2629, Type: screening]LANA [Human herpesvirus 8] [gi:139472804]
View
4
[SID862214]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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5
[SID862214]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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6
[SID862214]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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7
[SID862214]
 HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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8
[SID862214]
 HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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9
[SID862214]
 HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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10
[SID862214]
 HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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11
[SID862214]
 HTS for Estrogen Receptor-beta Coactivator Binding inhibitors [AID633, Type: screening]estrogen receptor beta isoform 1 [Homo sapiens] [gi:10835013]
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12
[SID862214]
 HTS for Estrogen Receptor-beta Coactivator Binding inhibitors [AID633, Type: screening]estrogen receptor beta isoform 1 [Homo sapiens] [gi:10835013]
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13
[SID862214]
 HTS for Estrogen Receptor-beta Coactivator Binding inhibitors [AID633, Type: screening]estrogen receptor beta isoform 1 [Homo sapiens] [gi:10835013]
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14
[SID862214]
 HTS of Smad transcription factor inhibitors [AID630, Type: screening]mothers against decapentaplegic homolog 3 [Homo sapiens] [gi:5174513]
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15
[SID862214]
 HTS of Smad transcription factor inhibitors [AID630, Type: screening]mothers against decapentaplegic homolog 3 [Homo sapiens] [gi:5174513]
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16
[SID862214]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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17
[SID862214]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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18
[SID862214]
IC50 50Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation [AID713, Type: confirmatory]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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19
[SID862214]
IC50 50Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation [AID713, Type: confirmatory]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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20
[SID862214]
IC50 50Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation [AID713, Type: confirmatory]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
View
21
[SID862214]
IC50 50Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation [AID713, Type: confirmatory]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
View
22
[SID862214]
IC50 50Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Response Confirmation [AID733, Type: confirmatory]estrogen receptor beta isoform 1 [Homo sapiens] [gi:10835013]
View
23
[SID862214]
IC50 50Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Response Confirmation [AID733, Type: confirmatory]estrogen receptor beta isoform 1 [Homo sapiens] [gi:10835013]
View
24
[SID862214]
IC50 50Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Response Confirmation [AID733, Type: confirmatory]estrogen receptor beta isoform 1 [Homo sapiens] [gi:10835013]
View
25
[SID862214]
EC50 75Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction [AID435023, Type: confirmatory]LANA [Human herpesvirus 8] [gi:139472804]
View
26
[SID862214]
Potency 89.1251HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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27
[SID862214]
IC50 999High Throughput Screening Assay for Hsc70 Inhibitors [AID568, Type: confirmatory]heat shock cognate 71 kDa protein isoform 1 [Homo sapiens] [gi:5729877]
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28
[SID862214]
IC50 999High Throughput Screening Assay for Hsc70 Inhibitors [AID568, Type: confirmatory]heat shock cognate 71 kDa protein isoform 1 [Homo sapiens] [gi:5729877]
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29
[SID862214]
IC50 999High Throughput Screening Assay for Hsc70 Inhibitors [AID568, Type: confirmatory]heat shock cognate 71 kDa protein isoform 1 [Homo sapiens] [gi:5729877]
View
30
[SID862214]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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31
[SID862214]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
View
32
[SID862214]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
View
33
[SID862214]
 Primary HTS assay for 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1a (5HT1a) antagonists [AID612, Type: screening]HTR1A gene product [Homo sapiens] [gi:55956923]
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34
[SID862214]
 Primary HTS assay for 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1a (5HT1a) antagonists [AID612, Type: screening]HTR1A gene product [Homo sapiens] [gi:55956923]
View
35
[SID862214]
 Primary HTS assay for 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1a (5HT1a) antagonists [AID612, Type: screening]HTR1A gene product [Homo sapiens] [gi:55956923]
View
36
[SID862214]
 Primary HTS assay for 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1a (5HT1a) agonists [AID567, Type: screening]HTR1A gene product [Homo sapiens] [gi:55956923]
View
37
[SID862214]
 Primary HTS assay for 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1a (5HT1a) agonists [AID567, Type: screening]HTR1A gene product [Homo sapiens] [gi:55956923]
View
38
[SID862214]
 Primary HTS assay for 5-Hydroxytryptamine (Serotonin) Receptor Subtype 1a (5HT1a) agonists [AID567, Type: screening]HTR1A gene product [Homo sapiens] [gi:55956923]
View
39
[SID862214]
 Primary Cell Based High Throughput Screening Assay for Agonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E) [AID574, Type: screening]5-hydroxytryptamine receptor 1E [gi:112822]
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40
[SID862214]
 Primary Cell Based High Throughput Screening Assay for Agonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E) [AID574, Type: screening]5-hydroxytryptamine receptor 1E [gi:112822]
View
41
[SID862214]
 Primary Cell Based High Throughput Screening Assay for Antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E) [AID571, Type: screening]5-hydroxytryptamine receptor 1E [gi:112822]
View
42
[SID862214]
 Primary Cell Based High Throughput Screening Assay for Antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E) [AID571, Type: screening]5-hydroxytryptamine receptor 1E [gi:112822]
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43
[SID862214]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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44
[SID862214]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
View
45
[SID862214]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
View
46
[SID862214]
 Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504634, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
View
47
[SID862214]
 Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504634, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
View
48
[SID862214]
 Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504634, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
View
49
[SID862214]
 Fluorescence polarization-based cell-based primary high throughput screening assay to identify activators of insulin-degrading enzyme (IDE) [AID493087, Type: screening]IDE gene product [Homo sapiens] [gi:155969707]
View
50
[SID862214]
 Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]IDE gene product [Homo sapiens] [gi:155969707]
View