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SMR000044166 (CID 663437) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(790)
 
 
Inconclusive(15)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(17)
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
PTPc(9)
 
 
BioAssay Types:
Screening(551)
 
 
 
 
Confirmatory(235)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(149)
 
 
 
 
IC50(52)
 
 
 
EC50(13)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 748    Data Row: 813   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID862214]
IC50 16TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70 [AID786, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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2
[SID862214]
IC50 55.1High Throughput Screening Assay for Hsp70 Inhibitors [AID583, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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3
[SID862214]
HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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4
[SID862214]
Fluorescence Polarization Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the LANA Histone H2A/H2B Interaction [AID2629, Type: screening]LANA [Human herpesvirus 8] [gi:139472804]
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5
[SID862214]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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6
[SID862214]
HTS for Estrogen Receptor-beta Coactivator Binding inhibitors [AID633, Type: screening]estrogen receptor beta isoform 1 [Homo sapiens] [gi:10835013]
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7
[SID862214]
HTS of Smad transcription factor inhibitors [AID630, Type: screening]mothers against decapentaplegic homolog 3 isoform 1 [Homo sapiens] [gi:5174513]
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8
[SID862214]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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9
[SID862214]
Potency 0.0002qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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10
[SID862214]
IC50 50Estrogen Receptor-beta Coactivator Binding Inhibitors Dose Response Confirmation [AID733, Type: confirmatory]estrogen receptor beta isoform 1 [Homo sapiens] [gi:10835013]
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11
[SID862214]
IC50 50Estrogen Receptor-alpha Coactivator Binding Inhibitors Dose Response Confirmation [AID713, Type: confirmatory]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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12
[SID862214]
EC50_uM 75Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction [AID435023, Type: confirmatory]LANA [Human herpesvirus 8] [gi:139472804]
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13
[SID862214]
Potency 89.1251HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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14
[SID862214]
IC50 999High Throughput Screening Assay for Hsc70 Inhibitors [AID568, Type: confirmatory]heat shock cognate 71 kDa protein isoform 2 [Homo sapiens] [gi:24234686]
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15
[SID862214]
IC50 999High Throughput Screening Assay for Hsc70 Inhibitors [AID568, Type: confirmatory]heat shock cognate 71 kDa protein isoform 1 [Homo sapiens] [gi:5729877]
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16
[SID862214]
Potency qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
View
17
[SID862214]
uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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18
[SID862214]
uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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19
[SID862214]
Primary cell-based high-throughput screening assay to identify agonists of Galanin Receptor 2 (GALR2) [AID803, Type: screening]Galanin receptor type 2 [gi:6016094]
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20
[SID862214]
Primary cell-based high-throughput screening assay to identify antagonists of Galanin Receptor 2 (GALR2) [AID828, Type: screening]Galanin receptor type 2 [gi:6016094]
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21
[SID862214]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6) [AID2599, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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22
[SID862214]
Primary cell-based high throughput screening assay to measure STAT1 inhibition [AID920, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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23
[SID862214]
Primary cell-based high throughput screening assay to measure STAT1 activation [AID932, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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24
[SID862214]
Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of the Ras-converting Enzyme [AID2563, Type: screening]Rce1p [Saccharomyces cerevisiae S288c] [gi:6323930]
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25
[SID862214]
HTS of Small Molecules that Regulate V-ATPase Proton Transport in Yeast using pHLuorin [AID504577, Type: screening]Vma11p [Saccharomyces cerevisiae S288c] [gi:6325022]
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26
[SID862214]
Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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27
[SID862214]
Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID1672, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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28
[SID862214]
Potency qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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29
[SID862214]
EC50 Luminescent HTS for small molecule inhibitors of MT1-MMP transcription [AID618, Type: confirmatory]matrix metalloproteinase 1 [Homo sapiens] [gi:6690534]
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30
[SID103074993]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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31
[SID862214]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex [AID504707, Type: screening]cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Mus musculus] [gi:6755076]
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32
[SID862214]
Kallikrein 5 1536 HTS [AID873, Type: screening]kallikrein-5 preproprotein [Homo sapiens] [gi:6912644]
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33
[SID862214]
Dyrk1 A HTS Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_SinglePoint_HTS_Activity [AID504441, Type: screening]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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34
[SID862214]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624037, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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35
[SID862214]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624038, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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36
[SID862214]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624040, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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37
[SID862214]
High Throughput Screening for Cocaine Antagonists: Primary Screen [AID449768, Type: screening]dopamine transporter [Homo sapiens] [gi:7108463]
View
38
[SID862214]
Potency qHTS of IL-2 Activators [AID652025, Type: confirmatory]interleukin-2 precursor [Mus musculus] [gi:7110653]
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39
[SID862214]
Primary biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase [AID1527, Type: screening]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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40
[SID862214]
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Mcl-1 [AID1009, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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41
[SID862214]
uHTS of Mcl-1/Bid interaction inhibitors [AID1021, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
View
42
[SID862214]
uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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43
[SID862214]
uHTS identification of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay [AID624204, Type: screening]sentrin-specific protease 1 [Homo sapiens] [gi:7657550]
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44
[SID862214]
qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Homo sapiens] [gi:7669492]
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45
[SID862214]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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46
[SID862214]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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47
[SID862214]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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48
[SID862214]
Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK9 [AID488922, Type: screening]potassium channel subfamily K member 9 [Homo sapiens] [gi:7706135]
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49
[SID862214]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase Methylesterase 1 (PME-1). [AID2130, Type: screening]protein phosphatase methylesterase 1 isoform a [Homo sapiens] [gi:7706645]
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50
[SID862214]
Factor XIa Mixture HTS [AID680, Type: screening]coagulation factor XI [Homo sapiens] [gi:180352]
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