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6-(3,4-dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine (CID 662965) - Compound BioActivity Data
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BioActivity Outcomes:
Active(97)
 
 
Inactive(820)
 
 
Inconclusive(36)
 
 
Unspecified(9)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
7TM GPCR Srsx(23)
 
 
 
alkPPc(12)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(550)
 
 
 
 
 
Confirmatory(369)
 
 
 
 
 
Literature(18)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(259)
 
 
 
 
 
IC50(64)
 
 
 
 
EC50(18)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 809    Data Row: 962   Total Pages: 49   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID861731]
Potency 0.0052qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID861731]
Potency 0.0058qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID103560865]
IC50 0.018Inhibition of PDE4D [AID314439, Type: Literature]
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4
[SID103560865]
IC50 0.024Inhibition of PDE4A [AID314437, Type: Literature]
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5
[SID861731]
Potency 0.0398Confirmation Concentration-Response Assay for Cell signaling CRE-BLA (Fsk stim) - HEK293 CREB Luciferase [AID907, Type: confirmatory]CREB-binding protein [gi:116241283]
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6
[SID103560865]
IC50 0.046Inhibition of human PDE4A by IMAP fluorescence polarization technology [AID425676, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4A [gi:116242706]
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7
[SID165222634]
AbsAC35_uM 0.0556Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent A673 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-03_Inhibitor_Dose_DryPowder_Activity [AID743478, Type: confirmatory]
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8
[SID165222634]
AbsAC35_uM 0.0613Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent TC71 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-04_Inhibitor_Dose_DryPowder_Activity [AID743477, Type: confirmatory]
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9
[SID29215094]
Potency 0.0708qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID29215094]
Potency 0.0708qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID861731]
EC50 0.1Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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12
[SID861731]
EC50 0.1Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID1990, Type: confirmatory]
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13
[SID165222634]
AbsAC35_uM 0.131Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_Dose_DryPowder_Activity [AID743479, Type: confirmatory]
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14
[SID165222634]
AbsAC35_uM 0.205A549 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-06_Inhibitor_Dose_DryPowder_Activity_Set12 [AID743472, Type: confirmatory]
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15
[SID861731]
EC50 0.3Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
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16
[SID861731]
Potency 0.3663A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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17
[SID861731]
Potency 0.3663A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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18
[SID165222634]
AbsAC35_uM 0.377HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader_7071-01_Inhibitor_Dose_DryPowder_Activity_Set15 [AID743470, Type: confirmatory]
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19
[SID861731]
Potency 0.4611qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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20
[SID861731]
EC50 0.494Luminescence Cell-Based Dose Response to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4-C Neuroglioblastoma Cells [AID2452, Type: confirmatory]
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