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bisphenol A (CID 6623) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(71)
 
 
Inactive(914)
 
 
Inconclusive(110)
 
 
Unspecified(138)
 
 
Top Targets:
7TM GPCR Srx(38)
 
 
 
7TM GPCR Srsx(32)
 
 
 
NR LBD PPAR(31)
 
 
 
 
NR LBD ER(22)
 
 
 
 
 
NR LBD AR(21)
 
 
 
 
BioAssay Types:
Confirmatory(614)
 
 
 
 
 
Screening(371)
 
 
 
Summary(48)
 
 
 
 
Literature(16)
 
 
 
 
 
BioActivity Types:
Potency(541)
 
 
 
 
 
IC50(148)
 
 
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 875    Data Row: 1233   Total Pages: 25   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144214049]
Potency-Replicate_1 0.2207qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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2
[SID144214049]
Potency-Replicate_1 0.4443qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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3
[SID144210190]
Potency-Replicate_1 0.4802qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID144210190]
Ratio Potency (uM) 1.12685qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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5
[SID103308477]
IC50 1.304DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: other]Arachidonate 15-lipoxygenase [gi:126397]
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6
[SID144214049]
Ratio Potency (uM) 1.50646qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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7
[SID144210190]
Potency-Replicate_1 1.9272qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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8
[SID103308477]
IC50 2.271DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: other]Estrogen receptor [gi:544257]
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9
[SID103308477]
IC50 5.42DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625221, Type: other]5-hydroxytryptamine receptor 6 [gi:1703010]
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10
[SID144214049]
Potency-Replicate_1 5.5426qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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11
[SID144210190]
Potency-Replicate_1 6.7823qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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12
[SID144214049]
Potency-Replicate_1 8.7076qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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13
[SID92277586]
Secondary IC50 9.3Identification of SV40 T antigen inhibitors: A Secondary Screen for the Cytotoxicity and Efficacy using BSC cells (3) [AID485276, Type: confirmatory]
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14
[SID144210190]
Ratio Potency (uM) 11.1698qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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15
[SID17390010]
Potency 13.3332qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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16
[SID144214049]
Potency-Replicate_1 13.9224qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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17
[SID144214049]
Potency-Replicate_1 13.9224qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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18
[SID144214049]
Ratio Potency (uM) 14.1778qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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19
[SID144210190]
Potency-Replicate_1 15.3085qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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20
[SID144214049]
Potency-Replicate_1 15.6211qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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21
[SID17390010]
Potency-Replicate_1 15.8489qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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22
[SID103308477]
IC50 16.62DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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23
[SID103308477]
IC50 19.015DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: other]Sodium-dependent dopamine transporter [gi:266667]
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24
[SID17389142]
Potency-Replicate_1 19.9526qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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25
[SID17390010]
Potency 19.9526qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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26
[SID103308477]
IC50 20.325DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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27
[SID144214049]
Potency-Replicate_1 22.2691qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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28
[SID144210190]
Potency-Replicate_1 24.2623qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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29
[SID144214049]
Potency-Replicate_1 24.9863qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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30
[SID17389142]
Potency 26.6032qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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31
[SID144210190]
Potency-Replicate_1 27.0008qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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32
[SID26752849]
Potency 30.6379qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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33
[SID144214049]
Potency-Replicate_1 30.6379qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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34
[SID144214049]
Ratio Potency (uM) 31.6884qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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35
[SID144210190]
Ratio Potency (uM) 31.7393qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
36
[SID144214049]
Ratio Potency (uM) 32.2108qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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37
[SID17390010]
Potency 33.4915qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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38
[SID103308477]
IC50 33.796DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) [AID625228, Type: other]Androgen receptor [gi:113832]
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39
[SID144214049]
Ratio Potency (uM) 39.6234qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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40
[SID26752849]
Potency-Replicate_1 39.8107qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
View
41
[SID144210190]
Ratio Potency (uM) 39.9575qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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42
[SID17389142]
Potency 42.1632qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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43
[SID144210190]
Ratio Potency (uM) 44.4676qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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44
[SID17390010]
Potency 47.3079qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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45
[SID144210190]
Potency-Replicate_1 48.0151qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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46
[SID144210190]
Potency-Replicate_1 53.8738qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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47
[SID144210190]
Potency-Replicate_1 60.4474qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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48
[SID144214049]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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49
[SID144214049]
Potency-Replicate_1 62.1889qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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50
[SID144214049]
Potency-Replicate_1 62.7627qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
View