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ChemDiv2_006091 (CID 6619281) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(524)
 
 
Inconclusive(7)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
B zip1(4)
 
 
BioAssay Types:
Screening(360)
 
 
 
Confirmatory(167)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(122)
 
 
 
 
IC50(33)
 
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 498    Data Row: 541   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104169547]
IC50 2.9A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (9) [AID504823, Type: confirmatory]
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2
[SID103061373]
IC50 3.1A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (4) [AID493016, Type: confirmatory]
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3
[SID104169547]
Average IC50 3.35A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (8) [AID504820, Type: confirmatory]
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4
[SID49735735]
IC50 3.4A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) [AID2391, Type: confirmatory]
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5
[SID103061373]
IC50 3.6A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6) [AID504526, Type: confirmatory]
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6
[SID104169547]
IC50 4.7A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (6) [AID504526, Type: confirmatory]
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7
[SID104169547]
Average CC50 50An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) using synethesized compounds (8) [AID504818, Type: confirmatory]
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8
[SID104169547]
CC50 145.7An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) using synethesized compounds (9) [AID504826, Type: confirmatory]
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9
[SID93616803]
A Titer Reduction Assay to evaluate Selected Compounds as new Inhibitors of Respiratory Syncytial Virus (RSV) [AID449732, Type: other]
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10
[SID49735735]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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11
[SID104169547]
CC50 50An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) using synethesized compounds (6) [AID504509, Type: confirmatory]
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12
[SID103061373]
CC50 50An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) using synethesized compounds (6) [AID504509, Type: confirmatory]
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13
[SID103061373]
CC50 50An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) using synethesized compounds (4) [AID493015, Type: confirmatory]
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14
[SID49735735]
CC50 An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) [AID2410, Type: confirmatory]
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15
[SID49735735]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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16
[SID49735735]
Small Molecules that selectively kill Giardia lamblia: qHTS [AID540267, Type: screening]
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17
[SID49735735]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Absorbance-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) full deck assay to identify assay artifacts [AID588335, Type: screening]
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18
[SID49735735]
uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay [AID602261, Type: screening]fatty acid synthase [Homo sapiens] [gi:41872631]
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19
[SID49735735]
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase3 Wildtype [AID1529, Type: screening]mitogen-activated protein kinase kinase kinase 3 isoform 1 [Homo sapiens] [gi:42794767]
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20
[SID49735735]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) [AID2012, Type: confirmatory]Eukaryotic translation initiation factor 4H [Homo sapiens] [gi:45219878]
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21
[SID49735735]
Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_Activity [AID504523, Type: screening]kelch-like ECH-associated protein 1 [Homo sapiens] [gi:45269145]
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22
[SID49735735]
IC50 uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. [AID1986, Type: confirmatory]envelope glycoprotein [Human immunodeficiency virus 1] [gi:45357394]
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23
[SID49735735]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) [AID2014, Type: confirmatory]polyadenylate-binding protein 1 [Homo sapiens] [gi:46367787]
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24
[SID49735735]
uHTS identification of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay [AID588489, Type: screening]polyadenylate-binding protein 1 [Homo sapiens] [gi:46367787]
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25
[SID49735735]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R2B (PKA-R2B) complex [AID504700, Type: screening]cAMP-dependent protein kinase catalytic subunit beta isoform 3 [Homo sapiens] [gi:46909587]
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26
[SID49735735]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R2B (PKA-R2B) complex [AID504700, Type: screening]cAMP-dependent protein kinase type II-beta regulatory subunit [Homo sapiens] [gi:47132585]
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27
[SID49735735]
uHTS fluorescent assay for identification of inhibitors of ATG4B [AID504462, Type: screening]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
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28
[SID49735735]
S100A4: HTS Measured in Biochemical System Using Plate Reader - 7045-01_Inhibitor_SinglePoint_HTS_Activity [AID652163, Type: screening]S100A4 [Homo sapiens] [gi:47496637]
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29
[SID92242109]
A screen for compounds that inhibit the CapD enzyme of Bacillus anthracis [AID492967, Type: other]gamma-glutamyltranspeptidase [Bacillus anthracis str. 'Ames Ancestor'] [gi:47566732]
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30
[SID49735735]
uHTS identification of small molecule activators of alpha dystroglycan glycosylation [AID624168, Type: screening]LARGE [Homo sapiens] [gi:47678551]
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31
[SID49735735]
Development of CDK5 inhibitors Measured in Biochemical System Using Plate Reader - 2083-01_Inhibitor_SinglePoint_HTS_Activity [AID488839, Type: screening]CDK5 [Homo sapiens] [gi:48146199]
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32
[SID49735735]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]troponin T, cardiac muscle isoform 3 [Homo sapiens] [gi:48255881]
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33
[SID49735735]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]troponin T, cardiac muscle isoform 3 [Homo sapiens] [gi:48255881]
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34
[SID49735735]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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35
[SID49735735]
Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of GSK-3 alpha [AID2650, Type: screening]glycogen synthase kinase-3 alpha [Homo sapiens] [gi:49574532]
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36
[SID49735735]
Potency qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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37
[SID49735735]
Potency qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624288, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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38
[SID49735735]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624125, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
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39
[SID49735735]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624126, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
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40
[SID49735735]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 4 (CHRM4) [AID624127, Type: screening]muscarinic acetylcholine receptor M4 [Homo sapiens] [gi:52426748]
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41
[SID49735735]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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42
[SID49735735]
QFRET-based counterscreen for PFM18AAP inhibitors: biochemical high throughput screening assay to identify inhibitors of the Cathepsin L proteinase (CTSL1). [AID1906, Type: screening]cathepsin L1 [Homo sapiens] [gi:55958172]
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43
[SID49735735]
Counterscreen for procaspase-3 activators: absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-7 [AID463210, Type: screening]caspase 7, apoptosis-related cysteine peptidase [Homo sapiens] [gi:55960760]
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44
[SID49735735]
MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary Screen [AID1832, Type: screening]Zinc finger protein mex-5 [gi:55976631]
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45
[SID49735735]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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46
[SID49735735]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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47
[SID49735735]
Potency qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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48
[SID49735735]
Counterscreen of compound fluorescence effects on High-throughput multiplex microsphere screening for inhibitors of toxin protease [AID624483, Type: screening]
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49
[SID49735735]
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
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50
[SID49735735]
DENV2 CPE-Based HTS Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2149-01_Other_SinglePoint_HTS_Activity [AID651640, Type: screening]
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