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SMR000034463 (CID 661788) - Compound BioActivity Data
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BioActivity Outcomes:
Active(30)
 
 
Inactive(841)
 
 
Inconclusive(38)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(32)
 
 
 
7TM GPCR Srsx(21)
 
 
TRP 2(20)
 
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
BioAssay Types:
Screening(583)
 
 
 
 
Confirmatory(301)
 
 
 
 
 
Literature(5)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(206)
 
 
 
 
 
IC50(52)
 
 
EC50(20)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 810    Data Row: 911   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26670736]
EC50 0.01406Luminescence-based cell-based high throughput dose response assay for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID588407, Type: confirmatory]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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2
[SID26670736]
EC50 0.01406Luminescence-based cell-based high throughput dose response assay for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID588407, Type: confirmatory]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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3
[SID26670736]
EC50 0.01731Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay to identify agonists of OPRD1 homodimerization [AID588411, Type: confirmatory]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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4
[SID860502]
EC50 0.1493Confirmation dose response assay for compounds that activate transient receptor potential cation channel C4 (TRPC4) [AID434937, Type: confirmatory]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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5
[SID860502]
Potency 0.631qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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6
[SID860502]
Potency 0.631Confirmation Concentration-Response Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID939, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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7
[SID860502]
Potency 10.4179Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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8
[SID124888752]
Potency 11.2202qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID860502]
Potency 12.5893qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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10
[SID860502]
Potency 15.8489qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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11
[SID57655021]
Potency 15.8489Secondary Concentration-Response Assay for Agonists of the Thyroid Stimulating Hormone Receptor: HTRF Activity Detection [AID933, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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12
[SID26670736]
Potency 31.6228qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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13
[SID860502]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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14
[SID860502]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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15
[SID57655021]
Potency 89.1251qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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16
[SID26670736]
Luminescence-based cell-based high throughput confirmation assay for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504904, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
View
17
[SID26670736]
Luminescence-based cell-based high throughput confirmation assay for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504904, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
View
18
[SID860502]
Specificity screen against TRPC6 for compounds that activate transient receptor potential cation channel C4 (TRPC4) [AID434950, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
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19
[SID26670736]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
View
20
[SID26670736]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
View
21
[SID860502]
Primary cell-based screen for identification of compounds that activate transient receptor potential cation channel C4 (TRPC4). [AID2237, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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22
[SID860502]
CYP2C19 Assay [AID778, Type: screening]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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23
[SID860502]
Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm [AID709, Type: screening]
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24
[SID860502]
Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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25
[SID860502]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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26
[SID860502]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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27
[SID26670736]
HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
View
28
[SID57655021]
Quantitative High-Throughput Screen for Agonists of Thyroid Stimulating Hormone Receptor: Summary [AID1401, Type: summary]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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29
[SID860502]
CYP2C9 Assay [AID777, Type: screening]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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30
[SID26670736]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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31
[SID26670736]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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32
[SID124888752]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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33
[SID860502]
Potency 1.5849qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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34
[SID860502]
Potency 3.9811qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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35
[SID860502]
Potency 14.1254qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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36
[SID860502]
Potency 14.1254qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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37
[SID26670736]
Potency 31.6228Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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38
[SID860502]
Potency 35.4813qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]pyruvate kinase PKM isoform a [Homo sapiens] [gi:33286418]
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39
[SID57655021]
Potency 35.4813qHTS Assay to Find Inhibitors of Pin1 [AID504891, Type: confirmatory]peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Homo sapiens] [gi:5453898]
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40
[SID860502]
Potency 50.1187qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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41
[SID26670736]
Potency 56.2341qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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42
[SID124888752]
Potency 79.4328qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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43
[SID26670736]
EC50 92.463Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID588408, Type: confirmatory]5-hydroxytryptamine receptor 5A [Homo sapiens] [gi:13236497]
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44
[SID26670736]
EC50 92.463Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay to identify agonists of OPRM1 homodimerization [AID588435, Type: confirmatory]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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45
[SID860502]
IC50 Fluorescence for the identification of compounds that decrease p/CIP protein stability [AID1984, Type: confirmatory]nuclear receptor coactivator 3 [Mus musculus] [gi:118026946]
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46
[SID860502]
Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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47
[SID860502]
Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504812, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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48
[SID26670736]
Potency Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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49
[SID860502]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID584, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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50
[SID860502]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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