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Ro 25-6981 (CID 6604887) - Compound BioActivity Data
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BioActivity Outcomes:
Active(28)
 
 
Inactive(159)
 
 
Inconclusive(15)
 
 
Unspecified(11)
 
 
Top Targets:
PBP1 iGluR NM..(10)
 
 
 
p450(9)
 
 
 
7tm 4(5)
 
 
 
PBP1 iGluR NM..(4)
 
 
PIKKc TOR(4)
 
 
 
BioAssay Types:
Confirmatory(156)
 
 
 
 
Literature(40)
 
 
 
 
Screening(11)
 
 
BioActivity Types:
Potency(137)
 
 
 
 
IC50(23)
 
 
 
Ki(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 180    Data Row: 213   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103264488]
Ki 0.0056Displacement of [3H]25-6981 from N-methyl-D-aspartate glutamate receptor [AID143454, Type: Literature]
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2
[SID103264488]
IC50 0.006Inhibition of [3H]Ro-256981 binding to N-methyl-D-aspartate glutamate receptor [AID143455, Type: Literature]
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3
[SID103264488]
IC50 0.006Inhibition of [3H]-Ro-25-6981 binding to NMDA receptor [AID241037, Type: Literature]
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4
[SID103264488]
Ki 0.006Binding affinity against NMDA receptor by displacement of [3H]Ro-256981 [AID143451, Type: Literature]
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5
[SID103264488]
IC50 0.006Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane [AID270544, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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6
[SID103264488]
IC50 0.006Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain [AID280089, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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7
[SID103264488]
IC50 0.009Antagonist activity against rat 1A/2B subtype of N-methyl-D-aspartate (NMDA) receptor in xenopus oocytes. [AID144695, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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8
[SID103264488]
IC50 0.009Antagonist activity against rat 1A/2B subtype of N-methyl-D-aspartate (NMDA) receptor in xenopus oocytes. [AID144695, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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9
[SID103264488]
IC50 0.009Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B. [AID143785, Type: Literature]
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10
[SID103264488]
IC50 0.009Inhibition of rat NMDA receptor NR1C/NR2B subunit expressed in Xenopus laevis oocytes after 2 days by two-electrode voltage-clamp electrophysiological assay [AID709970, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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11
[SID103264488]
IC50 0.009Inhibition of rat NMDA receptor NR1C/NR2B subunit expressed in Xenopus laevis oocytes after 2 days by two-electrode voltage-clamp electrophysiological assay [AID709970, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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12
[SID103264488]
Ki 0.01Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cells [AID144050, Type: Literature]
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13
[SID103264488]
IC50 0.017Inhibition of rat NMDA receptor NR1F/NR2B subunit expressed in Xenopus laevis oocytes after 2 days by two-electrode voltage-clamp electrophysiological assay [AID709969, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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14
[SID103264488]
IC50 0.017Inhibition of rat NMDA receptor NR1F/NR2B subunit expressed in Xenopus laevis oocytes after 2 days by two-electrode voltage-clamp electrophysiological assay [AID709969, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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15
[SID103264488]
IC50 0.057Inhibition of NMDA-evoked increased intracellular [Ca2+] in cells expressing NR1/NR2B receptor [AID242374, Type: Literature]
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16
[SID103264488]
IC50 0.057Inhibition of N-methyl-D-aspartate glutamate receptor-evoked increase of intracellular Ca+ in cells expressing NMDA glutamate receptor 1/2B [AID143378, Type: Literature]
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17
[SID103264488]
IC50 0.159Inhibition of NMDA-evoked increase in intracellular calcium ion in rat cortical cells [AID270545, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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18
[SID103264488]
IC50 0.159Inhibition of NMDA-evoked increase in intracellular calcium ion in rat cortical cells [AID270545, Type: Literature]Glutamate receptor ionotropic, NMDA 2A [gi:3915771]
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19
[SID103264488]
IC50 0.159Inhibition of NMDA-evoked increase in intracellular calcium ion in rat cortical cells [AID270545, Type: Literature]Glutamate receptor ionotropic, NMDA 2C [gi:548374]
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20
[SID103264488]
IC50 0.159Inhibition of NMDA-evoked increase in intracellular calcium ion in rat cortical cells [AID270545, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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