Bookmark and Share
Ro 25-6981 (CID 6604887) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(28)
 
 
Inactive(157)
 
 
Inconclusive(15)
 
 
Unspecified(11)
 
 
Top Targets:
PBP1 iGluR NM..(11)
 
 
 
p450(9)
 
 
 
PIKKc TOR(4)
 
 
 
7TM GPCR Srx(4)
 
 
 
Pyr redox dim(4)
 
 
BioAssay Types:
Confirmatory(155)
 
 
 
 
Literature(40)
 
 
 
 
Screening(10)
 
 
BioActivity Types:
Potency(136)
 
 
 
 
IC50(23)
 
 
 
Ki(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 178    Data Row: 211   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103264488]
Ki 0.0056Displacement of [3H]25-6981 from N-methyl-D-aspartate glutamate receptor [AID143454, Type: Literature]
View
2
[SID103264488]
IC50 0.006Inhibition of [3H]Ro-256981 binding to N-methyl-D-aspartate glutamate receptor [AID143455, Type: Literature]
View
3
[SID103264488]
Ki 0.006Binding affinity against NMDA receptor by displacement of [3H]Ro-256981 [AID143451, Type: Literature]
View
4
[SID103264488]
IC50 0.006Inhibition of [3H]-Ro-25-6981 binding to NMDA receptor [AID241037, Type: Literature]
View
5
[SID103264488]
IC50 0.006Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane [AID270544, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
View
6
[SID103264488]
IC50 0.006Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain [AID280089, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
View
7
[SID103264488]
IC50 0.009Inhibition of rat NMDA receptor NR1C/NR2B subunit expressed in Xenopus laevis oocytes after 2 days by two-electrode voltage-clamp electrophysiological assay [AID709970, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
View
8
[SID103264488]
IC50 0.009Antagonist activity against rat 1A/2B subtype of N-methyl-D-aspartate (NMDA) receptor in xenopus oocytes. [AID144695, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
View
9
[SID103264488]
IC50 0.009Antagonist activity against rat 1A/2B subtype of N-methyl-D-aspartate (NMDA) receptor in xenopus oocytes. [AID144695, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
View
10
[SID103264488]
IC50 0.009Inhibition of rat NMDA receptor NR1C/NR2B subunit expressed in Xenopus laevis oocytes after 2 days by two-electrode voltage-clamp electrophysiological assay [AID709970, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
View
11
[SID103264488]
IC50 0.009Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2B. [AID143785, Type: Literature]
View
12
[SID103264488]
Ki 0.01Displacement of [3H]ifenprodil binding to recombinant human NR1a/NR2B receptors expressed in L(tk-) cells [AID144050, Type: Literature]
View
13
[SID103264488]
IC50 0.017Inhibition of rat NMDA receptor NR1F/NR2B subunit expressed in Xenopus laevis oocytes after 2 days by two-electrode voltage-clamp electrophysiological assay [AID709969, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
View
14
[SID103264488]
IC50 0.017Inhibition of rat NMDA receptor NR1F/NR2B subunit expressed in Xenopus laevis oocytes after 2 days by two-electrode voltage-clamp electrophysiological assay [AID709969, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
View
15
[SID103264488]
IC50 0.057Inhibition of N-methyl-D-aspartate glutamate receptor-evoked increase of intracellular Ca+ in cells expressing NMDA glutamate receptor 1/2B [AID143378, Type: Literature]
View
16
[SID103264488]
IC50 0.057Inhibition of NMDA-evoked increased intracellular [Ca2+] in cells expressing NR1/NR2B receptor [AID242374, Type: Literature]
View
17
[SID103264488]
IC50 0.159Inhibition of NMDA-evoked increase in intracellular calcium ion in rat cortical cells [AID270545, Type: Literature]Glutamate receptor ionotropic, NMDA 2C [gi:548374]
View
18
[SID103264488]
IC50 0.159Inhibition of NMDA-evoked increase in intracellular calcium ion in rat cortical cells [AID270545, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
View
19
[SID103264488]
IC50 0.159Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium concentration [AID280088, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
View
20
[SID103264488]
IC50 0.159Inhibition of NMDA-evoked increase in intracellular calcium ion in rat cortical cells [AID270545, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
View
21
[SID103264488]
IC50 0.159Inhibition of NMDA-evoked increase in intracellular calcium ion in rat cortical cells [AID270545, Type: Literature]Glutamate receptor ionotropic, NMDA 2A [gi:3915771]
View
22
[SID103264488]
IC50 0.159Inhibition of NMDA-evoked increase in intracellular calcium ion in rat cortical cells [AID270545, Type: Literature]Glutamate receptor ionotropic, NMDA 3B [gi:51701630]
View
23
[SID103264488]
IC50 0.159Inhibition of NMDA-evoked increase in intracellular calcium ion in rat cortical cells [AID270545, Type: Literature]Glutamate receptor ionotropic, NMDA 3A [gi:51701631]
View
24
[SID103264488]
IC50 0.159Inhibition of NMDA-evoked increase in intracellular calcium ion in rat cortical cells [AID270545, Type: Literature]Glutamate receptor ionotropic, NMDA 2D [gi:18202594]
View
25
[SID103264488]
Ki 0.18In vitro binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]prazosin radioligand [AID36300, Type: Literature]
View
26
[SID103264488]
IC50 0.4Neuroprotective activity in rat Cortical neuron assessed as protection from glutamate-induced neurotoxicity treated after glutamate-challenge by lactate dehydrogenase assay [AID730402, Type: Literature]
View
27
[SID90341730]
Potency 14.1254HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
View
28
[SID90341730]
Potency 23.1093qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
View
29
[SID103264488]
IC50 52Antagonistic activity against N-methyl-D-aspartate glutamate receptor 1/2A. [AID143779, Type: Literature]
View
30
[SID103264488]
Selectivity ratio of alpha-1 receptor to that of NMDA was determined [AID226400, Type: Literature]
View
31
[SID103264488]
In vivo activity was measured in mice after ip administration using standard sound-induced seizures assay [AID112519, Type: Literature]
View
32
[SID103264488]
In vivo analgesic activity was tested using formalin test in mouse upon i.p. administration [AID246884, Type: Literature]
View
33
[SID103264488]
Inhibition of formalin induced nociception in ip dosed NMRI mouse by measuring pain-related licking behavior in late phase [AID280093, Type: Literature]
View
34
[SID103264488]
Anticonvulsant activity in ip dosed DBA/2 mouse assessed as inhibition of auditory stimulation-induced clonic seizures administered 30 mins before auditory stimulation [AID392781, Type: Literature]
View
35
[SID103264488]
Anticonvulsant activity in ip dosed DBA/2 mouse assessed as inhibition of auditory stimulation-induced tonic seizures administered 30 mins before auditory stimulation [AID392782, Type: Literature]
View
36
[SID11114147]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
View
37
[SID103264488]
Ratio of compound IC50 to ifenprodil IC50 for wild type NR1/NR2B receptor by radioligand binding assay [AID502301, Type: Literature]
View
38
[SID103264488]
Displacement of [3H]ifenprodil from wild type NR1/NR2B receptor expressed in Xenopus oocytes [AID502302, Type: Literature]
View
39
[SID103264488]
Antagonist activity at NMDA receptor GluN2B subunit in FVB mouse CA1 pyramidal neurons assessed as decrease in EPSC amplitude at holding potential of -60 mV at 6 uM measured at 5 mins by patch clamp electrophysiological assay in presence of Mg2+ free ACSF containing CNQX, glycine, bicuculline relative to control [AID709973, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:14549168]
View
40
[SID90341730]
Potency 1.6359HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
View
41
[SID11114147]
Potency 15.8489qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
View
42
[SID11114147]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
43
[SID11114147]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
View
44
[SID11114147]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
View
45
[SID11114147]
Potency qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
View
46
[SID85788156]
EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Reader - 2125-01_Inhibitor_SinglePoint_HTS_Activity [AID651548, Type: screening]histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens] [gi:21361095]
View
47
[SID11114147]
qHTS Assay for Inhibitors of YjeE [AID605, Type: confirmatory]tRNA threonylcarbamoyladenosine biosynthesis protein TsaE [gi:84028058]
View
48
[SID11114147]
Potency Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
View
49
[SID90341730]
Potency Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
View
50
[SID11114147]
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
View