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Tocris-0759 (CID 6604755) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inactive(85)
 
 
Inconclusive(12)
 
 
Unspecified(1)
 
 
Top Targets:
p450(9)
 
 
 
PLN02808(4)
 
 
HSD10-like SD..(4)
 
 
PLDc mTdp1 2(3)
 
 
GH31 MGAM SI..(3)
 
 
 
BioAssay Types:
Confirmatory(93)
 
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(73)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 90    Data Row: 100   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID11113687]
Potency 14.1254qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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2
[SID11113687]
Potency 35.4813qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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3
[SID11113687]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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4
[SID11113687]
Potency 0.5623Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2113, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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5
[SID11113687]
Potency Confirmation of Inhibitors and Activators of Purified Human alpha-Glucosidase [AID2115, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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6
[SID11113687]
Potency qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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7
[SID11113687]
Potency Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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8
[SID11113687]
GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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9
[SID11113687]
GR-EFC Redistribution [AID451, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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10
[SID11113687]
JNK3 AlphaScreen Assay [AID530, Type: confirmatory]Mitogen-activated protein kinase 10 [gi:2499604]
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11
[SID11113687]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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12
[SID11113687]
Potency qHTS for inhibitors of Vif-A3G interactions: Validation [AID588379, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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13
[SID11113687]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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14
[SID11113687]
Potency qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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15
[SID11113687]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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16
[SID11113687]
Potency qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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17
[SID11113687]
Potency qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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18
[SID11113687]
Potency qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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19
[SID11113687]
Potency qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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20
[SID11113687]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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