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4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid (CID 6603901) - Compound BioActivity Data
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BioActivity Outcomes:
Active(31)
 
 
Inactive(698)
 
 
Inconclusive(94)
 
 
Unspecified(17)
 
 
Top Targets:
NR LBD PPAR(40)
 
 
 
 
 
7TM GPCR Srx(26)
 
 
 
7TM GPCR Srsx(16)
 
 
p450(11)
 
 
 
 
B zip1(10)
 
 
 
 
BioAssay Types:
Confirmatory(415)
 
 
 
 
 
Screening(325)
 
 
 
Literature(47)
 
 
 
 
 
Summary(25)
 
 
 
 
BioActivity Types:
Potency(392)
 
 
 
 
 
EC50(16)
 
 
 
 
IC50(12)
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 746    Data Row: 840   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144212730]
Ratio Potency (uM) 0.00616448qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway: Summary [AID743227, Type: summary]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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2
[SID144212730]
Potency-Replicate_1 0.011qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway [AID743212, Type: confirmatory]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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3
[SID103399375]
EC50 0.021Agonist activity at human GAL4-fused PPARdelta ligand binding domain expressed in COS-1 cells after 20 hrs by luciferase reporter gene transactivation assay [AID712385, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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4
[SID103399375]
EC50 0.039Transactivation of GAL4-fused human PPARdelta ligand binding domain transfected in african green monkey COS7 cells by luciferase reporter gene assay [AID709644, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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5
[SID103399375]
EC50 0.125Activity at PPARbeta/delta by luciferase reporter gene transactivation assay in COS7 cells [AID270378, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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6
[SID144212730]
Ratio Potency (uM) 0.149015qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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7
[SID144212730]
Potency-Replicate_1 0.2754qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway [AID743094, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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8
[SID103399375]
EC50 0.53Agonist activity for Human PPAR delta receptor in transcriptional activation assay [AID91241, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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9
[SID103399375]
EC50 0.64Transactivation of GAL4-fused PPARbeta LBD expressed in HepG2 cells after 20 hrs by luminescence assay [AID652614, Type: Literature]
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10
[SID103399375]
EC50 0.65Transactivation of GAL4-fused PPARbeta (delta) ligand binding domain transfected in human HepG2 cells after 20 hrs by luciferase reporter gene assay [AID696369, Type: Literature]
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11
[SID103399375]
EC50 0.977Activity at PPARalpha by luciferase reporter gene transactivation assay in COS7 cells [AID270379, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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12
[SID103399375]
EC50 1.824Activity at PPARgamma by luciferase reporter gene transactivation assay in COS7 cells [AID270380, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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13
[SID56463274]
AC50_uM 2.54Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-02_Inhibitor_Dose_CherryPick_Activity [AID651683, Type: confirmatory]bioA [Mycobacterium tuberculosis UT205] [gi:378544807]
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14
[SID103399375]
EC50 3.8Agonist activity for murine PPAR delta receptor in transcriptional activation assay [AID141908, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:548577]
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15
[SID103399375]
EC50 5.5Agonist activity for Human PPAR gamma receptor in transcriptional activation assay [AID91246, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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16
[SID11111371]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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17
[SID103399375]
EC50 10Agonist activity for murine PPAR gamma receptor in transcriptional activation assay [AID141913, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
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18
[SID103399375]
EC50 10Agonist activity for Human PPAR alpha receptor in transcriptional activation assay [AID91237, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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19
[SID26753592]
Potency 11.2202qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway [AID651778, Type: confirmatory]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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20
[SID90341011]
Potency 50.1187Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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21
[SID144212730]
Potency-Replicate_1 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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22
[SID124880537]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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23
[SID90341011]
Potency 79.4328Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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24
[SID11111371]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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25
[SID11111371]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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26
[SID11111371]
Cell signaling CRE-BLA (Fsk stim) [AID662, Type: confirmatory]
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27
[SID56463274]
Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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28
[SID56463274]
Fluorescence-based biochemical high throughput confirmation assay to identify molecules that bind r(CAG) RNA repeats [AID652065, Type: screening]
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29
[SID56463274]
Counterscreen for molecules that bind rCAG RNA repeats: fluorescent based biochemical counterscreen assay for inhibitors of the DNA-based (5'CAG/3'GTC) TO-PRO-1 dye complex [AID652068, Type: screening]
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30
[SID56463274]
Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-01_Inhibitor_SinglePoint_HTS_Activity [AID602481, Type: screening]bioA [Mycobacterium tuberculosis UT205] [gi:378544807]
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31
[SID144212730]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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32
[SID103399375]
Selectivity ratio for human PPRalpha over human PPRbeta/delta [AID677058, Type: Literature]
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33
[SID103399375]
Selectivity ratio for human PPRgamma over human PPRbeta/delta [AID677059, Type: Literature]
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34
[SID103399375]
Selectivity ratio for mouse PPRalpha over mouse PPRbeta/delta [AID677060, Type: Literature]
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35
[SID103399375]
Selectivity ratio for mouse PPRgamma to mouse PPRbeta/delta [AID677061, Type: Literature]
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36
[SID26753592]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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37
[SID11111371]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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38
[SID103399375]
Selectivity for human PPARdelta over human PPARalpha [AID270384, Type: Literature]
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39
[SID56463274]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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40
[SID103399375]
Selectivity for human PPARdelta over human PPARgamma [AID270385, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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41
[SID103399375]
Activity at PPARbeta/delta by luciferase reporter gene transactivation assay in COS7 cells relative to MWI66 at 1 uM [AID270381, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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42
[SID103399375]
Selectivity for human PPARdelta over human PPARgamma [AID270386, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
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43
[SID103399375]
Agonist activity at human GAL4-fused PPARdelta ligand binding domain expressed in COS-1 cells after 20 hrs by luciferase reporter gene transactivation assay relative to L165041 [AID712386, Type: Literature]Peroxisome proliferator-activated receptor delta [gi:417522]
View
44
[SID103399375]
Activity at PPARalpha by luciferase reporter gene transactivation assay in COS7 cells relative to WY-14643 at 10 uM [AID270382, Type: Literature]Peroxisome proliferator-activated receptor alpha [gi:3041727]
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45
[SID103399375]
Activity at PPARgamma by luciferase reporter gene transactivation assay in COS7 cells relative to rosiglitazone at 1 uM [AID270383, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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46
[SID103399375]
Selectivity for human PPARdelta over human PPARgamma [AID270385, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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47
[SID103399375]
Selectivity for human PPARdelta over human PPARgamma [AID270386, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
48
[SID50106426]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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49
[SID50106426]
Potency 0.0224qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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50
[SID90341011]
Potency 0.12qHTS screen for enhancers of Arylsulfatase A (ASA1): LOPAC Validation Assay [AID720538, Type: confirmatory]arylsulfatase A [Homo sapiens] [gi:220983390]
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