GR 89696 (CID 6603856) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(19)
 
 
Inactive(135)
 
 
Inconclusive(20)
 
 
Unspecified(18)
 
 
Top Targets:
p450(20)
 
 
 
 
PLN02808(5)
 
 
NR LBD GR(4)
 
 
 
HSD10-like SD..(4)
 
 
P53(4)
 
 
BioAssay Types:
Confirmatory(144)
 
 
 
 
Literature(22)
 
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(103)
 
 
 
 
Ki(6)
 
 
IC50(5)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 139    Data Row: 192   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103191018]
IC50 1.8e-05Agonist activity at kappa opioid receptor in rabbit vas deferens [AID481113, Type: Literature]
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2
[SID103191018]
IC50 2e-05Agonistic activity at kappa opioid receptor of rabbit vas deferens [AID223583, Type: other]
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3
[SID103191018]
IC50 4.1e-05In vitro agonist activity at kappa opioid receptor in rabbit vas deferens. [AID148434, Type: Literature]
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4
[SID103191018]
Ki 0.00036Displacement of [(3)H]U69593 from mu opioid receptor [AID481114, Type: Literature]
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5
[SID103191018]
Ki 0.00045Displacement of [3H]U69593 from kappa opioid receptor [AID601794, Type: Literature]
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6
[SID103191018]
Ki 0.00045Affinity to opioid receptor kappa 1 using [3H]U-69593 as radioligand in homogenates of guinea pig brain membranes [AID148988, Type: other]
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7
[SID103191018]
Ki 0.000502Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting [AID631359, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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8
[SID103191018]
Ki 0.000502Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting [AID631359, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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9
[SID103191018]
Ki 0.000502Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting [AID631359, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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10
[SID103191018]
Ki 0.000502Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting [AID631359, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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11
[SID103191018]
Ki 0.0347Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting [AID631360, Type: Literature]Mu-type opioid receptor [gi:2851402]
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12
[SID103191018]
Ki 0.0347Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting [AID631360, Type: Literature]Mu-type opioid receptor [gi:2851402]
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13
[SID103191018]
Ki 0.0347Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting [AID631360, Type: Literature]Mu-type opioid receptor [gi:2851402]
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14
[SID103191018]
Ki 0.0347Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting [AID631360, Type: Literature]Mu-type opioid receptor [gi:2851402]
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15
[SID103191018]
Ki 0.422Displacement of [3H]diprenorphine from human opioid delta receptor expressed in HEK293 cells after 120 mins by scintillation counting [AID631361, Type: Literature]Delta-type opioid receptor [gi:311033488]
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16
[SID103191018]
Ki 0.422Displacement of [3H]diprenorphine from human opioid delta receptor expressed in HEK293 cells after 120 mins by scintillation counting [AID631361, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
17
[SID11114102]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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18
[SID11114102]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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19
[SID11114102]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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20
[SID11114102]
Potency 12.5893qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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21
[SID11114102]
Potency 12.5893qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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22
[SID11114102]
Potency 12.5893qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
View
23
[SID11111217]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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24
[SID11111217]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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25
[SID11111217]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
View
26
[SID11114102]
Potency 25.1189qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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27
[SID11114102]
Potency 25.1189qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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28
[SID11114102]
 Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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29
[SID11114102]
 Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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30
[SID11114102]
 GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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31
[SID11114102]
 GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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32
[SID11114102]
 GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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33
[SID11114102]
 GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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34
[SID11114102]
 Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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35
[SID11114102]
 Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
View
36
[SID11111217]
 Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
View
37
[SID11111217]
 Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
View
38
[SID11114102]
 Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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39
[SID11114102]
 Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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40
[SID11114102]
 Schistosoma Mansoni Peroxiredoxins (Prx2) [AID448, Type: confirmatory]thioredoxin peroxidase [Schistosoma mansoni] [gi:4325211]
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41
[SID103191018]
IC50 10In vitro inhibitory activity against mu specific tissue of rat vas deferens [AID224585, Type: Literature]
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42
[SID103191018]
IC50 10In vitro inhibitory activity against delta specific tissue of hamster vas deferens [AID147942, Type: Literature]
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43
[SID11114102]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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44
[SID11114102]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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45
[SID103191018]
 Ratio of antinociceptive activity measured using mouse acetylcholine induced abdominal constriction test by s.c. administration to that done by i.c.v. [AID230917, Type: other]
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46
[SID103191018]
 In vivo antinociceptive activity was determined using rat paw pressure test following subcutaneous administration; range (0.00058-0.0014) [AID176998, Type: Literature]
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47
[SID11111217]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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48
[SID11111217]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
View
49
[SID103191018]
 Selectivity ratio of Ki for human opioid mu receptor expressed in CHO cells to Ki for human opioid kappa receptor expressed in CHO cells [AID631362, Type: Literature]
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50
[SID103191018]
 Selectivity ratio of Ki for human opioid delta receptor expressed in HEK293 cells to Ki for human opioid kappa receptor expressed in CHO cells [AID631363, Type: Literature]
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