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GR 89696 (CID 6603856) - Compound BioActivity Data
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BioActivity Outcomes:
Active(19)
 
 
Inactive(145)
 
 
Inconclusive(20)
 
 
Unspecified(18)
 
 
Top Targets:
p450(18)
 
 
 
HSD10-like SD..(8)
 
 
7TM GPCR Srx(8)
 
 
 
 
PLN02808(5)
 
 
BRCT(4)
 
 
BioAssay Types:
Confirmatory(154)
 
 
 
 
Literature(23)
 
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(112)
 
 
 
 
Ki(6)
 
 
IC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 141    Data Row: 202   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103191018]
IC50 1.8e-05Agonist activity at kappa opioid receptor in rabbit vas deferens [AID481113, Type: Literature]
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2
[SID103191018]
IC50 2e-05Agonistic activity at kappa opioid receptor of rabbit vas deferens [AID223583, Type: other]
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3
[SID103191018]
IC50 4.1e-05In vitro agonist activity at kappa opioid receptor in rabbit vas deferens. [AID148434, Type: Literature]
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4
[SID103191018]
Ki 0.00036Displacement of [(3)H]U69593 from mu opioid receptor [AID481114, Type: Literature]
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5
[SID103191018]
Ki 0.00045Displacement of [3H]U69593 from kappa opioid receptor [AID601794, Type: Literature]
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6
[SID103191018]
Ki 0.00045Affinity to opioid receptor kappa 1 using [3H]U-69593 as radioligand in homogenates of guinea pig brain membranes [AID148988, Type: Literature]Kappa-type opioid receptor [gi:730228]
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7
[SID103191018]
Ki 0.000502Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting [AID631359, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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8
[SID103191018]
Ki 0.0347Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting [AID631360, Type: Literature]Mu-type opioid receptor [gi:2851402]
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9
[SID103191018]
Ki 0.422Displacement of [3H]diprenorphine from human opioid delta receptor expressed in HEK293 cells after 120 mins by scintillation counting [AID631361, Type: Literature]Delta-type opioid receptor [gi:311033488]
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10
[SID11114102]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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11
[SID11114102]
Potency 12.5893qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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12
[SID11111217]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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13
[SID11114102]
Potency 25.1189qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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14
[SID11114102]
Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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15
[SID11114102]
Schistosoma Mansoni Peroxiredoxins (Prx2) [AID448, Type: confirmatory]thioredoxin peroxidase [Schistosoma mansoni] [gi:4325211]
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16
[SID11114102]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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17
[SID11111217]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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18
[SID11114102]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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19
[SID11114102]
GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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20
[SID103191018]
IC50 10In vitro inhibitory activity against delta specific tissue of hamster vas deferens [AID147942, Type: Literature]
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21
[SID103191018]
IC50 10In vitro inhibitory activity against mu specific tissue of rat vas deferens [AID224585, Type: Literature]
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22
[SID103191018]
Ratio of antinociceptive activity measured using mouse acetylcholine induced abdominal constriction test by s.c. administration to that done by i.c.v. [AID230917, Type: other]
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23
[SID103191018]
Binding constant in rabbit vas deferens (LVD) antagonized by naloxone [AID148441, Type: Literature]
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24
[SID103191018]
In vivo antinociceptive activity was determined using rat paw pressure test following subcutaneous administration; range (0.00058-0.0014) [AID176998, Type: Literature]
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25
[SID103191018]
Lipophilicity was expressed as Log D [AID18969, Type: other]
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26
[SID103191018]
Tested in vivo for antinociceptive activity using the mouse acetylcholine induced abdominal constriction test by intracerebroventricular (i.c.v.) administration [AID132113, Type: other]
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27
[SID103191018]
Tested in vivo for antinociceptive activity using the mouse acetylcholine induced abdominal constriction test by subcutaneous (s.c.) administration [AID132115, Type: other]
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28
[SID103191018]
In vivo antinociceptive activity was determined using mouse acetylcholine induced abdominal constriction test following oral administration; range (0.005-0.035) [AID132778, Type: Literature]
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29
[SID103191018]
In vivo antinociceptive activity was determined using mouse acetylcholine induced abdominal constriction test following subcutaneous administration; range (0.00012-0.00045) [AID132781, Type: Literature]
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30
[SID103191018]
In vivo antinociceptive activity was determined using mouse acetylcholine induced abdominal constriction test following subcutaneous administration; range (0.00027-0.00086) [AID132782, Type: Literature]
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31
[SID103191018]
BBB penetration classification [AID135326, Type: Literature]
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32
[SID11111217]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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33
[SID11114102]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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34
[SID103191018]
Selectivity ratio of Ki for human opioid mu receptor expressed in CHO cells to Ki for human opioid kappa receptor expressed in CHO cells [AID631362, Type: Literature]
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35
[SID103191018]
Selectivity ratio of Ki for human opioid delta receptor expressed in HEK293 cells to Ki for human opioid kappa receptor expressed in CHO cells [AID631363, Type: Literature]
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36
[SID103191018]
Drug uptake in rat striatum at 1.5 ug/kg, iv measured after 40 mins by LC/MS-MS analysis [AID631398, Type: Literature]
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37
[SID103191018]
Ratio of drug uptake in striatum to cerebellum in rat at 1.5 ug/kg, iv measured after 40 mins by LC/MS/MS analysis [AID631402, Type: Literature]
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38
[SID11114102]
Potency 10qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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39
[SID11111217]
Potency 15.8489qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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40
[SID11111217]
Potency qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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41
[SID11111217]
Potency qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Green Fluorophore) [AID879, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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42
[SID11114102]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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43
[SID11114102]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1 [AID900, Type: confirmatory]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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44
[SID11111217]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1 [AID900, Type: confirmatory]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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45
[SID11111217]
Potency qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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46
[SID11114102]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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47
[SID11114102]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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48
[SID11111217]
Potency qHTS Assay for Anthrax Lethal Toxin Internalization [AID912, Type: confirmatory]lethal factor [Bacillus anthracis str. A2012] [gi:21392848]
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49
[SID11111217]
Potency qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway [AID895, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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50
[SID11111217]
Potency qHTS Assay for Identification of Small Molecule Agonists for NFkB Signaling Pathway [AID928, Type: confirmatory]NFKB1 protein [Homo sapiens] [gi:21620132]
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