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BioActivity Data for Compound GR 89696 (CID 6603856)

BioActivity Outcomes:
Active(15)
 
 
Inactive(146)
 
 
Inconclusive(20)
 
 
Unspecified(12)
 
 
Top Targets:
p450(18)
 
 
 
7tm 4(9)
 
 
 
 
HSD10-like SD..(8)
 
 
GH27(5)
 
 
ampC(4)
 
 
BioAssay Types:
Confirmatory(156)
 
 
 
 
Literature(12)
 
 
 
 
Screening(1)
 
 
BioAssay Categories:
In vivo(4)
 
 
Biochemical(9)
 
 
 
 
Toxicity(4)
 
 
ADME(3)
 
 
Cell-based(8)
 
 
 
 
BioActivity Types:
Potency(113)
 
 
 
 
Ki(4)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 132    Data Row: 193   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103191018]
IC50 2e-05Agonistic activity at kappa opioid receptor of rabbit vas deferens [AID223583, Type: confirmatory]
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2
[SID103191018]
Ki 0.00045Affinity to opioid receptor kappa 1 using [3H]U-69593 as radioligand in homogenates of guinea pig brain membranes [AID148988, Type: Literature]Kappa-type opioid receptor [gi:730228]
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3
[SID103191018]
Ki 0.000502Displacement of [3H]diprenorphine from human opioid kappa receptor expressed in CHO cells after 120 mins by scintillation counting [AID631359, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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4
[SID103191018]
Ki 0.0347Displacement of [3H]diprenorphine from human opioid mu receptor expressed in CHO cells after 120 mins by scintillation counting [AID631360, Type: Literature]Mu-type opioid receptor [gi:2851402]
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5
[SID103191018]
Ki 0.422Displacement of [3H]diprenorphine from human opioid delta receptor expressed in HEK293 cells after 120 mins by scintillation counting [AID631361, Type: Literature]Delta-type opioid receptor [gi:311033488]
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6
[SID11114102]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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7
[SID11114102]
Potency 12.5893qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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8
[SID11111217]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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9
[SID11114102]
Potency 25.1189qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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10
[SID11114102]
Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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11
[SID11114102]
Schistosoma Mansoni Peroxiredoxins (Prx2) [AID448, Type: confirmatory]thioredoxin peroxidase [Schistosoma mansoni] [gi:4325211]
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12
[SID11114102]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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13
[SID11111217]
Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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14
[SID11114102]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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15
[SID11114102]
GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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16
[SID103191018]
Lipophilicity was expressed as Log D [AID18969, Type: other]
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17
[SID103191018]
Tested in vivo for antinociceptive activity using the mouse acetylcholine induced abdominal constriction test by intracerebroventricular (i.c.v.) administration [AID132113, Type: other]
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18
[SID103191018]
Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 [AID1159387, Type: other]
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19
[SID103191018]
BBB penetration classification [AID135326, Type: Literature]
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20
[SID103191018]
Ratio of antinociceptive activity measured using mouse acetylcholine induced abdominal constriction test by s.c. administration to that done by i.c.v. [AID230917, Type: other]
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