SMR000065862 (CID 6603393) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(7)
 
 
Inactive(725)
 
 
Inconclusive(17)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
alkPPc(14)
 
 
Bcl-2 like(11)
 
 
7TM GPCR Srsx(10)
 
 
Tryp SPc(10)
 
 
BioAssay Types:
Screening(501)
 
 
 
 
Confirmatory(227)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(150)
 
 
 
 
 
IC50(44)
 
 
EC50(11)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 750    Data Row: 750   Total Pages: 15   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID3716615]
Potency 11.9955qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID3716615]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID3716615]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID3716615]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID3716615]
Potency 50.1187qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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6
[SID3716615]
 Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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7
[SID3716615]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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8
[SID3716615]
AbsAC40_uM Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_Dose_CherryPick_Activity [AID651717, Type: confirmatory]
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9
[SID3716615]
 Primary Cell-based High Throughput Screening assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID522, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
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10
[SID3716615]
 Primary Cell-based High Throughput Screening assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID522, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
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11
[SID3716615]
 Primary Cell-based High Throughput Screening assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID522, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
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12
[SID3716615]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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13
[SID3716615]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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14
[SID3716615]
Potency 3.2885qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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15
[SID3716615]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7 cells) [AID430, Type: confirmatory]
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16
[SID3716615]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
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17
[SID3716615]
 MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Activator_SinglePoint_HTS_Activity [AID651723, Type: screening]
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18
[SID3716615]
 HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_SinglePoint_HTS_Activity [AID651654, Type: screening]
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19
[SID3716615]
 Luminescence-based counterscreen assay for KLF5 inhibitors: cell-based high throughput screening assay to identify cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1825, Type: screening]
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20
[SID3716615]
IC50 A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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21
[SID3716615]
IC50 A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID1863, Type: confirmatory]
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22
[SID3716615]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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23
[SID3716615]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Polyadenylation [AID1875, Type: screening]
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24
[SID3716615]
 Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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25
[SID3716615]
 Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID1910, Type: screening]
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26
[SID3716615]
Potency qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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27
[SID3716615]
Conc @ Max Fold Increase A high-throughput screen to identify small molecule compounds that augment HSV replication [AID1956, Type: confirmatory]
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28
[SID3716615]
 Fluorescence Biochemical Primary HTS to Identify Inhibitors of GASC-1 Activity [AID2099, Type: screening]
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29
[SID3716615]
 Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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30
[SID3716615]
 Cell Proliferation & Viability (Cytotoxicity) Primary Assay 60K MLSMR [AID463, Type: screening]
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31
[SID3716615]
 Primary HTS assay for chemical inhibitors of antigen receptor-induced NF-kappaB activation [AID465, Type: screening]
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32
[SID3716615]
 Ubiquitin-GFP Assay [AID526, Type: confirmatory]
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33
[SID3716615]
 qHTS Assay for Spectroscopic Profiling in Resorufin Spectral Region [AID588, Type: other]
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34
[SID3716615]
 qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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35
[SID3716615]
 qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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36
[SID3716615]
 qHTS Assay for Spectroscopic Profiling in A488 Spectral Region [AID591, Type: other]
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37
[SID3716615]
 qHTS Assay for Spectroscopic Profiling in A647 Spectral Region [AID592, Type: other]
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38
[SID3716615]
 qHTS Assay for Spectroscopic Profiling in Rhodamine Spectral Region [AID594, Type: confirmatory]
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39
[SID3716615]
 qHTS Assay for Disrupters of an Hsp90 Co-Chaperone Interaction [AID595, Type: confirmatory]
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40
[SID3716615]
 Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTS [AID573, Type: screening]
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41
[SID3716615]
 qHTS Assay for Epigenetic Modulators [AID597, Type: confirmatory]
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42
[SID3716615]
 Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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43
[SID3716615]
 Identification of Molecular Probes that Reverse MRP-Mediated Drug Resistance [AID602, Type: screening]
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44
[SID3716615]
 qHTS Assay for Inhibitors of DNA Polymerase III Holoenzyme System [AID603, Type: confirmatory]
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45
[SID3716615]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HT1080 cells) [AID620, Type: confirmatory]
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46
[SID3716615]
 Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [AID626, Type: screening]
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47
[SID3716615]
 Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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48
[SID3716615]
 Isolation of Inhibitors of Her-Kinase Expression - 66K library screen [AID645, Type: screening]
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49
[SID3716615]
 Human Endothelial Cell Proliferation Assay in 384-well format [AID648, Type: screening]
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50
[SID3716615]
 Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN. [AID2029, Type: screening]citrate synthase 2 [Saccharomyces cerevisiae] [gi:171229]
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