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Dichloroacetic Acid (CID 6597) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(674)
 
 
Inconclusive(35)
 
 
Unspecified(24)
 
 
Top Targets:
NR LBD PPAR(34)
 
 
 
NR LBD ER(25)
 
 
 
NR LBD AR(25)
 
 
 
NR LBD TR(17)
 
 
 
 
NR LBD VDR(17)
 
 
BioAssay Types:
Confirmatory(416)
 
 
 
 
Screening(131)
 
 
 
Literature(83)
 
 
 
Summary(72)
 
 
 
BioActivity Types:
Potency(418)
 
 
 
 
IC50(10)
 
 
 
EC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 442    Data Row: 740   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144210737]
Potency-Replicate_1 54.4827qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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2
[SID48413570]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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3
[SID48413570]
DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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4
[SID48413570]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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5
[SID48413570]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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6
[SID48413570]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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7
[SID48415880]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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8
[SID103176116]
EC50 100In vitro effective concentration in normal human dermal fibroblasts [AID90949, Type: Literature]
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9
[SID103176116]
IC50 2000In vitro inhibitory activity against pyruvate dehydrogenase kinase was determined [AID162967, Type: Literature]
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10
[SID103176116]
Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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11
[SID103176116]
Mutagenic activity in Salmonella Typhimurium TA100 assessed as logarithm of his+ revertant number increasing activity by amens test [AID384212, Type: Literature]
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12
[SID17389935]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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13
[SID103176116]
Volume of distribution at steady state in human after iv administration [AID540209, Type: Literature]
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14
[SID103176116]
Clearance in human after iv administration [AID540210, Type: Literature]
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15
[SID103176116]
Mean residence time in human after iv administration [AID540212, Type: Literature]
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16
[SID103176116]
Half life in human after iv administration [AID540213, Type: Literature]
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17
[SID144204684]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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18
[SID103176116]
In vivo activity in a diabetic mouse at a dose of 1000 umol/kg/day on day 3 after 2 hr [AID131105, Type: Literature]
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19
[SID103176116]
In vivo activity in a diabetic mouse at a dose of 1000 umol/kg/day on day 3 after 4 hr [AID131106, Type: Literature]
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20
[SID103176116]
In vivo activity in a diabetic mouse at a dose of 1000 umol/kg/day on day 3 after 6 hr [AID131107, Type: Literature]
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21
[SID103176116]
In vivo activity in a diabetic mouse at a dose of 1000 umol/kg/day on day1 after 2 hours [AID131108, Type: Literature]
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22
[SID103176116]
In vivo activity in a diabetic mouse at a dose of 1000 umol/kg/day on day1 after 4 hr [AID131109, Type: Literature]
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23
[SID103176116]
In vivo activity in a diabetic mouse at a dose of 1000 umol/kg/day on day1 after 6 hr [AID131110, Type: Literature]
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24
[SID103176116]
Partition coefficient (logP) [AID23251, Type: Literature]
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25
[SID103176116]
Partition coefficient (logP) (benzene) [AID23252, Type: Literature]
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26
[SID103176116]
Partition coefficient (logP) (carbon tetrachloride) [AID23253, Type: Literature]
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27
[SID103176116]
Partition coefficient (logP) (chloroform) [AID23254, Type: Literature]
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28
[SID103176116]
Partition coefficient (logP) (ether) [AID23255, Type: Literature]
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29
[SID103176116]
Partition coefficient (logP) (hexane) [AID23256, Type: Literature]
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30
[SID26753010]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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31
[SID103176116]
Substrates for human cytosolic glutathione transferase GSTZ1 [AID589015, Type: other]Maleylacetoacetate isomerase [gi:269849671]
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32
[SID144204684]
Potency-Replicate_1 37.578qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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33
[SID144204684]
Potency-Replicate_1 qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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34
[SID144204684]
Ratio Potency (uM) qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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35
[SID144204684]
Potency-Replicate_1 qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway measured by Nrf2-dependant transcriptional activity - cell viability counter screen [AID720653, Type: confirmatory]
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36
[SID144204684]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cells [AID720674, Type: confirmatory]
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37
[SID144204684]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cells [AID720675, Type: confirmatory]
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38
[SID144204684]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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39
[SID144204684]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cells [AID720679, Type: confirmatory]
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40
[SID144204684]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
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41
[SID144204684]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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42
[SID144204684]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
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43
[SID144204684]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free culture [AID720683, Type: confirmatory]
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44
[SID144204684]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cell free culture [AID720684, Type: confirmatory]
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45
[SID144204684]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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46
[SID144204684]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cell free culture [AID720686, Type: confirmatory]
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47
[SID144204684]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cells [AID720687, Type: confirmatory]
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48
[SID144204684]
Potency-Replicate_1 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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49
[SID144204684]
Potency-Replicate_1 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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50
[SID144204684]
Potency-Replicate_1 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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