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Oxindole-Based Inhibitor 19 (CID 6539046) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(2)
 
 
Unspecified(456)
 
 
Top Targets:
PKc(42)
 
 
PKc like(42)
 
 
PTKc Abl(16)
 
 
STKc AGC(16)
 
 
PTKc Src like(10)
 
 
BioAssay Types:
Literature(5)
 
 
BioActivity Types:
IC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 465    Data Row: 465   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103577757]
IC50 0.36Evaluated for inhibition of human cyclin dependent kinase 2 (CDK2) [AID53361, Type: Literature]
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2
[SID103577757]
IC50 0.36Inhibitory activity against human cyclin-dependent kinase 2 (CDK2) [AID53362, Type: Literature]
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3
[SID103577757]
IC50 0.36Inhibition of CDK2 [AID320938, Type: Literature]
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4
[SID103577757]
IC50 2.3Inhibition of CDK1 [AID320948, Type: Literature]
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5
[SID103577757]
IC50 2.3Inhibitory activity against human cyclin-dependent kinase 1 (CDK1) [AID55538, Type: Literature]
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6
[SID134352559]
A screen for small compounds that change glucocorticoid sensitivity in NFkB suppression [AID624486, Type: other]
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7
[SID134352559]
A screen for compounds that activate the pro-inflammatory immune response in murine macrophages [AID652131, Type: other]
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8
[SID103577757]
GSK_PKIS: CDK2/cyclinA mean inhibition at 0.1 uM [Nanosyn] [AID651164, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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9
[SID103577757]
GSK_PKIS: CDK2/cyclinA mean inhibition at 1 uM [Nanosyn] [AID651165, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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10
[SID103577757]
GSK_PKIS: CDK2/cyclinE mean inhibition at 0.1 uM [Nanosyn] [AID651166, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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11
[SID103577757]
GSK_PKIS: CDK2/cyclinE mean inhibition at 1 uM [Nanosyn] [AID651167, Type: other]Cyclin-dependent kinase 2 [gi:116051]
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12
[SID103577757]
GSK_PKIS: ERBB2 mean inhibition at 0.1 uM [Nanosyn] [AID651424, Type: other]Receptor tyrosine-protein kinase erbB-2 [gi:119533]
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13
[SID103577757]
GSK_PKIS: ERBB2 mean inhibition at 1 uM [Nanosyn] [AID651425, Type: other]Receptor tyrosine-protein kinase erbB-2 [gi:119533]
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14
[SID103577757]
GSK_PKIS: MAPK1 mean inhibition at 0.1 uM [Nanosyn] [AID651196, Type: other]Mitogen-activated protein kinase 1 [gi:119554]
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15
[SID103577757]
GSK_PKIS: MAPK1 mean inhibition at 1 uM [Nanosyn] [AID651197, Type: other]Mitogen-activated protein kinase 1 [gi:119554]
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16
[SID103577757]
GSK_PKIS: FGFR1 mean inhibition at 0.1 uM [Nanosyn] [AID651432, Type: other]Fibroblast growth factor receptor 1 [gi:120046]
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17
[SID103577757]
GSK_PKIS: FGFR1 mean inhibition at 1 uM [Nanosyn] [AID651433, Type: other]Fibroblast growth factor receptor 1 [gi:120046]
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18
[SID103577757]
GSK_PKIS: FGFR2 mean inhibition at 0.1 uM [Nanosyn] [AID651434, Type: other]Fibroblast growth factor receptor 2 [gi:120049]
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19
[SID103577757]
GSK_PKIS: FGFR2 mean inhibition at 1 uM [Nanosyn] [AID651435, Type: other]Fibroblast growth factor receptor 2 [gi:120049]
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20
[SID103577757]
GSK_PKIS: FGFR3 mean inhibition at 0.1 uM [Nanosyn] [AID651436, Type: other]Fibroblast growth factor receptor 3 [gi:120050]
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21
[SID103577757]
GSK_PKIS: FGFR3 mean inhibition at 1 uM [Nanosyn] [AID651437, Type: other]Fibroblast growth factor receptor 3 [gi:120050]
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22
[SID103577757]
GSK_PKIS: IGF1R mean inhibition at 0.1 uM [Nanosyn] [AID651252, Type: other]Insulin-like growth factor 1 receptor [gi:124240]
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23
[SID103577757]
GSK_PKIS: IGF1R mean inhibition at 1 uM [Nanosyn] [AID651253, Type: other]Insulin-like growth factor 1 receptor [gi:124240]
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24
[SID103577757]
GSK_PKIS: PKA mean inhibition at 0.1 uM [Nanosyn] [AID651040, Type: other]cAMP-dependent protein kinase catalytic subunit alpha [gi:125205]
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25
[SID103577757]
GSK_PKIS: PKA mean inhibition at 1 uM [Nanosyn] [AID651041, Type: other]cAMP-dependent protein kinase catalytic subunit alpha [gi:125205]
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26
[SID103577757]
GSK_PKIS: FGR mean inhibition at 0.1 uM [Nanosyn] [AID651440, Type: other]Tyrosine-protein kinase Fgr [gi:125358]
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27
[SID103577757]
GSK_PKIS: FGR mean inhibition at 1 uM [Nanosyn] [AID651441, Type: other]Tyrosine-protein kinase Fgr [gi:125358]
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28
[SID103577757]
GSK_PKIS: FYN mean inhibition at 0.1 uM [Nanosyn] [AID651248, Type: other]Tyrosine-protein kinase Fyn [gi:125370]
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29
[SID103577757]
GSK_PKIS: FYN mean inhibition at 1 uM [Nanosyn] [AID651249, Type: other]Tyrosine-protein kinase Fyn [gi:125370]
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30
[SID103577757]
GSK_PKIS: KIT mean inhibition at 0.1 uM [Nanosyn] [AID651268, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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31
[SID103577757]
GSK_PKIS: KIT mean inhibition at 1 uM [Nanosyn] [AID651269, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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32
[SID103577757]
GSK_PKIS: KIT (D816V mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651270, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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33
[SID103577757]
GSK_PKIS: KIT (D816V mutant) mean inhibition at 1 uM [Nanosyn] [AID651271, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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34
[SID103577757]
GSK_PKIS: KIT (T6701 mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651272, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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35
[SID103577757]
GSK_PKIS: KIT (T6701 mutant) mean inhibition at 1 uM [Nanosyn] [AID651273, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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36
[SID103577757]
GSK_PKIS: KIT (V560G mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651274, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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37
[SID103577757]
GSK_PKIS: KIT (V560G mutant) mean inhibition at 1 uM [Nanosyn] [AID651275, Type: other]Mast/stem cell growth factor receptor Kit [gi:125472]
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38
[SID103577757]
GSK_PKIS: LCK mean inhibition at 0.1 uM [Nanosyn] [AID651276, Type: other]Tyrosine-protein kinase Lck [gi:125474]
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39
[SID103577757]
GSK_PKIS: LCK mean inhibition at 1 uM [Nanosyn] [AID651277, Type: other]Tyrosine-protein kinase Lck [gi:125474]
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40
[SID103577757]
GSK_PKIS: LYN A (splice variant) mean inhibition at 0.1 uM [Nanosyn] [AID651280, Type: other]Tyrosine-protein kinase Lyn [gi:125480]
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41
[SID103577757]
GSK_PKIS: LYN A (splice variant) mean inhibition at 1 uM [Nanosyn] [AID651281, Type: other]Tyrosine-protein kinase Lyn [gi:125480]
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42
[SID103577757]
GSK_PKIS: LYN B (splice variant) mean inhibition at 0.1 uM [Nanosyn] [AID651282, Type: other]Tyrosine-protein kinase Lyn [gi:125480]
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43
[SID103577757]
GSK_PKIS: LYN B (splice variant) mean inhibition at 1 uM [Nanosyn] [AID651283, Type: other]Tyrosine-protein kinase Lyn [gi:125480]
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44
[SID103577757]
GSK_PKIS: PHKG2 mean inhibition at 0.1 uM [Nanosyn] [AID651134, Type: other]Phosphorylase b kinase gamma catalytic chain, liver/testis isoform [gi:125536]
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45
[SID103577757]
GSK_PKIS: PHKG2 mean inhibition at 1 uM [Nanosyn] [AID651135, Type: other]Phosphorylase b kinase gamma catalytic chain, liver/testis isoform [gi:125536]
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46
[SID103577757]
GSK_PKIS: CRAF mean inhibition at 0.1 uM [Nanosyn] [AID651458, Type: other]RAF proto-oncogene serine/threonine-protein kinase [gi:125651]
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47
[SID103577757]
GSK_PKIS: CRAF mean inhibition at 1 uM [Nanosyn] [AID651459, Type: other]RAF proto-oncogene serine/threonine-protein kinase [gi:125651]
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48
[SID103577757]
GSK_PKIS: SRC mean inhibition at 0.1 uM [Nanosyn] [AID651314, Type: other]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
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49
[SID103577757]
GSK_PKIS: SRC mean inhibition at 1 uM [Nanosyn] [AID651315, Type: other]Proto-oncogene tyrosine-protein kinase Src [gi:125711]
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50
[SID103577757]
GSK_PKIS: YES mean inhibition at 0.1 uM [Nanosyn] [AID651450, Type: other]Tyrosine-protein kinase Yes [gi:125870]
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