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7H-purine-6-thiol hydrate (CID 6537489) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(62)
 
 
Inactive(278)
 
 
Inconclusive(159)
 
 
Unspecified(4)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
NR LBD ER(9)
 
 
 
NR LBD AR(9)
 
 
 
NR LBD TR(7)
 
 
 
NR LBD VDR(7)
 
 
 
BioAssay Types:
Confirmatory(243)
 
 
 
 
Literature(63)
 
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(224)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 267    Data Row: 503   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17389218]
Potency 0.1995Confirmation and Secondary Assay for Modulators of Hemoglobin Beta Chain Splicing at IVS2 654 locus: Cytotoxicity [AID931, Type: confirmatory]hemoglobin subunit beta [Homo sapiens] [gi:4504349]
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2
[SID144208192]
Potency-Replicate_1 0.5448qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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3
[SID144208192]
Potency-Replicate_1 1.2197qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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4
[SID17389218]
Potency 1.58489Confirmation and Secondary Assays for Modulators of Hemoglobin Beta Chain Splicing at IVS2 654 and 705 loci [AID1405, Type: confirmatory]hemoglobin subunit beta [Homo sapiens] [gi:4504349]
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5
[SID17389218]
Potency 1.5849Cell Viability - LYMP1-003 - Assay at 40 hr [AID964, Type: confirmatory]
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6
[SID17389218]
Potency 2.2387qHTS assay for cell viability of HEK293 cells [AID743288, Type: confirmatory]
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7
[SID17389218]
Potency 2.2387qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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8
[SID17389218]
Potency 2.8695S16 Schwann cell PMP22 intronic element firefly luciferase assay [AID624032, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
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9
[SID144208192]
Potency-Replicate_1 3.0918qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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10
[SID17389218]
Potency 3.1623Confirmation and Secondary Assay for Modulators of Hemoglobin Beta Chain Splicing at IVS2 654 locus [AID910, Type: confirmatory]hemoglobin subunit beta [Homo sapiens] [gi:4504349]
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11
[SID17389218]
Potency 3.1623Confirmation and Secondary Assay for Modulators of Hemoglobin Beta Chain Splicing at IVS2 705 locus [AID930, Type: confirmatory]hemoglobin subunit beta [Homo sapiens] [gi:4504349]
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12
[SID144208192]
Ratio Potency (uM) 3.18365qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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13
[SID144208192]
Potency-Replicate_1 3.4376qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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14
[SID144208192]
Ratio Potency (uM) 4.85577qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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15
[SID144208192]
Potency-Replicate_1 4.8558qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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16
[SID144208192]
Potency-Replicate_1 4.8558qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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17
[SID144208192]
Ratio Potency (uM) 5.66142qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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18
[SID144208192]
Potency-Replicate_1 7.7663qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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19
[SID17389218]
Potency 10qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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20
[SID144208192]
Potency-Replicate_1 10.9702qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743218, Type: confirmatory]
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21
[SID144208192]
Potency-Replicate_1 10.9702qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen [AID743074, Type: confirmatory]
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22
[SID17389218]
Potency 14.1254qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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23
[SID17389218]
Potency 14.1254qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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24
[SID17389218]
Potency 17.7693S16 Schwann cell PMP22 intronic element beta-lactamase assay [AID624044, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
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25
[SID17389218]
Potency 22.3872qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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26
[SID17389218]
Potency 23.7101qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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27
[SID144208192]
Potency-Replicate_1 30.6379qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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28
[SID144208192]
Potency-Replicate_1 30.6379qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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29
[SID17389218]
Potency 42.1632qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]interleukin 8 [Homo sapiens] [gi:186368]
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30
[SID144208192]
AhR Potency (uM) 43.2771qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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31
[SID144208192]
Potency-Replicate_1 48.5577qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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32
[SID144208192]
Potency-Replicate_1 54.4827qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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33
[SID17389218]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812_75, Type: other]
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34
[SID17389218]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812_76, Type: other]
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35
[SID17389218]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812_73, Type: other]
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36
[SID17389218]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812_80, Type: other]
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37
[SID17389218]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_1, Type: other]
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38
[SID17389218]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
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39
[SID17389218]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_6, Type: other]
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40
[SID17389218]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812_36, Type: other]
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41
[SID17389218]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812_46, Type: other]
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42
[SID17389218]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812_54, Type: other]
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43
[SID17389218]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812_64, Type: other]
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44
[SID17389218]
Cell Viability Profiling of Human Lymphoblast Cell Lines [AID588812_69, Type: other]
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45
[SID17389218]
Cell Viability - NIH 3T3 [AID541, Type: confirmatory]
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46
[SID17389218]
Cell Viability - H-4-II-E [AID543, Type: confirmatory]
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47
[SID17389218]
Cell Viability - Mesenchymal [AID546, Type: confirmatory]
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48
[SID17389218]
Cell Viability - BJ [AID421, Type: confirmatory]
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49
[SID17389218]
Cell Viability - Jurkat [AID426, Type: confirmatory]
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50
[SID17389218]
Cell Viability - Hek293 [AID427, Type: confirmatory]
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