SMR000013127 (CID 653589) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(37)
 
 
Inactive(694)
 
 
Inconclusive(32)
 
 
Unspecified(6)
 
 
Top Targets:
7TM GPCR Srx(20)
 
 
alkPPc(14)
 
 
Bcl-2 like(11)
 
 
Tryp SPc(10)
 
 
7TM GPCR Srsx(10)
 
 
BioAssay Types:
Screening(499)
 
 
 
 
Confirmatory(242)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(149)
 
 
 
 
 
IC50(56)
 
 
 
 
EC50(11)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 760    Data Row: 769   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID87225745]
IC50 0.965SAR Analysis of Selective Antagonists of GPR55 using an Image-Based Assay - Set 2 [AID2820, Type: confirmatory]G-protein coupled receptor 55 [Homo sapiens] [gi:33695107]
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2
[SID851037]
Potency 1qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1: Spectroscopic Profiling in AFC Spectral Region [AID923, Type: confirmatory]
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3
[SID851037]
IC50 1.23598Image-Based HTS for Selective Antagonists for GPR55 [AID2013, Type: confirmatory]G-protein coupled receptor 55 [Homo sapiens] [gi:33695107]
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4
[SID26668122]
Potency 3.5481A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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5
[SID26668122]
Potency 7.0795A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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6
[SID851037]
IC50 11.9Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630, Type: confirmatory]
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7
[SID851037]
IC50 11.9Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_1, Type: confirmatory]
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8
[SID26668122]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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9
[SID851037]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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10
[SID851037]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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11
[SID851037]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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12
[SID851037]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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13
[SID851037]
 High throughput discovery of novel modulators of ROMK K+ channel activity: Primary Screen [AID1918, Type: screening]Potassium inwardly-rectifying channel, subfamily J, member 1 [Homo sapiens] [gi:223460826]
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14
[SID851037]
 Confirmatory screen for identification of compounds that inhibit transient receptor potential cation channel C6 (TRPC6) [AID488960, Type: screening]short transient receptor potential channel 6 [Mus musculus] [gi:160333370]
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15
[SID851037]
 uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assay [AID588493, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
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16
[SID851037]
 qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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17
[SID851037]
 qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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18
[SID851037]
 Primary cell-based high-throughput screening assay to identify agonists of Galanin Receptor 2 (GALR2) [AID803, Type: screening]Galanin receptor type 2 [gi:6016094]
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19
[SID851037]
 Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Primary Screen [AID628, Type: screening]Muscarinic acetylcholine receptor M [gi:113121]
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20
[SID851037]
 Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Primary Screen [AID628, Type: screening]Muscarinic acetylcholine receptor M [gi:113121]
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21
[SID851037]
 Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Primary Screen [AID628, Type: screening]Muscarinic acetylcholine receptor M [gi:113121]
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22
[SID851037]
 Counter screen assay of the parental HEK293 cells for compounds that activate the Choline Transporter (CHT) [AID623908, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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23
[SID851037]
 Counter screen assay of the parental HEK293 cells for compounds that activate the Choline Transporter (CHT) [AID623908, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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24
[SID851037]
 Confirmatory screen for compounds that activate the Choline Transporter (CHT) [AID504833, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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25
[SID851037]
 Confirmatory screen for compounds that activate the Choline Transporter (CHT) [AID504833, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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26
[SID851037]
 Specificity screen against TRPC4 for compounds that modulate transient receptor potential cation channel C6 (TRPC6) [AID488927, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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27
[SID851037]
 Second specificity screen against TRPC4 for compounds that modulate transient receptor potential cation channel C6 (TRPC6) [AID488928, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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28
[SID851037]
 High throughput screening of inhibitors of transient receptor potential cation channel C6 (TRPC6) [AID2553, Type: screening]short transient receptor potential channel 6 [Mus musculus] [gi:160333370]
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29
[SID851037]
 Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Confirmation Screen [AID677, Type: other]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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30
[SID851037]
 Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Confirmation Screen [AID677, Type: other]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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31
[SID851037]
 Discovery of novel allosteric modulators of the M1 muscarinic receptor: Antagonist Confirmation Screen [AID677, Type: other]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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32
[SID26668122]
 Rml C and D fluorescent artifact dose-response confirmation [AID1696, Type: confirmatory]dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD [Mycobacterium tuberculosis H37Rv] [gi:15610402]
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33
[SID851037]
 Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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34
[SID851037]
 Single concentration confirmation of small molecule Triacylglycerol inhbitors in a fluoresence assay [AID651629, Type: screening]
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35
[SID851037]
 uHTS identification of small molecule Triacylglycerol inhbitors in a fluoresence assay [AID651582, Type: screening]
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36
[SID851037]
 Counter screen for compounds that modulate transient receptor potential cation channel C6 (TRPC6) [AID488924, Type: screening]
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37
[SID26668122]
 Rml C and D inhibition 384-well mixture HTS [AID1532, Type: screening]
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38
[SID851037]
 384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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39
[SID851037]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HT1080 cells) [AID620, Type: confirmatory]
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40
[SID851037]
 Human H69AR Lung Tumor Cell Growth Inhibition Assay [AID580, Type: screening]
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41
[SID851037]
 Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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42
[SID851037]
 qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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43
[SID851037]
 qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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44
[SID851037]
 Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm [AID709, Type: screening]
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45
[SID26668122]
 uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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46
[SID851037]
IC50 uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. [AID1434, Type: confirmatory]core-binding factor subunit beta isoform 1 [Homo sapiens] [gi:13124881]
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47
[SID851037]
IC50 uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. [AID1434, Type: confirmatory]core-binding factor subunit beta isoform 1 [Homo sapiens] [gi:13124881]
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48
[SID851037]
IC50 8.067Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_2, Type: confirmatory]
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49
[SID851037]
IC50 15.762Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_3, Type: confirmatory]
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50
[SID851037]
IC50 25Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_5, Type: confirmatory]
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