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6-Methoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid (CID 652912) - Compound BioActivity Data
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BioActivity Outcomes:
Active(124)
 
 
Inactive(669)
 
 
Inconclusive(50)
 
 
Unspecified(2)
 
 
Top Targets:
7tm 4(46)
 
 
Bcl-2 like(15)
 
 
 
G-alpha(14)
 
 
 
 
alkPPc(12)
 
 
 
Tryp SPc(10)
 
 
BioAssay Types:
Screening(497)
 
 
 
 
 
Confirmatory(307)
 
 
 
 
 
Literature(13)
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(182)
 
 
 
 
 
IC50(71)
 
 
 
 
EC50(17)
 
 
 
 
AC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 751    Data Row: 845   Total Pages: 43   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID850390]
Potency 1qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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2
[SID850390]
IC50 1.1Dose Response confirmation of UBC13 Polyubiquitin Inhibitors using a Bfl-1 counterscreen [AID504689, Type: confirmatory]bcl-2-related protein A1 [Mus musculus] [gi:11024684]
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3
[SID850390]
Potency 1.2589qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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4
[SID850390]
IC50 1.28HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target [AID521, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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5
[SID850390]
Potency 1.7783qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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6
[SID850390]
Potency 2.5119qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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7
[SID850390]
Potency 2.5119qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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8
[SID850390]
Potency 2.8184qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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9
[SID850390]
Potency 3.1623qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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10
[SID850390]
Potency 3.1623qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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11
[SID850390]
Potency 3.5481qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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12
[SID850390]
IC50 4.46uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2091, Type: confirmatory]voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 [Homo sapiens] [gi:4502523]
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13
[SID850390]
IC50 4.46uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2091, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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14
[SID26514192]
IC50 6.26In Vitro Hsp70 Dose Response Fluorescence Polarization Assay for SAR Study [AID1072, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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15
[SID850390]
Potency 7.0795qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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16
[SID850390]
Potency 7.9433qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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17
[SID850390]
Potency 7.9433qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation with Orthogonal Assay [AID504375, Type: confirmatory]core-binding factor subunit beta isoform 2 [Homo sapiens] [gi:13124873]
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18
[SID850390]
Potency 7.9433qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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19
[SID850390]
Potency 7.9433qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation with Orthogonal Assay [AID504375, Type: confirmatory]runt-related transcription factor 1 isoform AML1b [Homo sapiens] [gi:49574546]
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20
[SID850390]
Potency 7.9433qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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