GW 1929 (CID 6518171) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(42)
 
 
Inactive(178)
 
 
Inconclusive(46)
 
 
Unspecified(145)
 
 
Top Targets:
p450(21)
 
 
 
 
 
7TM GPCR Srx(12)
 
 
 
NR LBD PPAR(12)
 
 
 
 
7TM GPCR Srsx(10)
 
 
 
PLN02808(7)
 
 
BioAssay Types:
Confirmatory(201)
 
 
 
 
 
Literature(51)
 
 
 
 
Screening(11)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(159)
 
 
 
 
 
IC50(119)
 
 
 
EC50(7)
 
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 349    Data Row: 411   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103391063]
EC50 0.0037Displacement of pan-PPAR fluormone from PPARgamma LBD by TR-FRET based LanthaScreen assay [AID675851, Type: Literature]
View
2
[SID103391063]
EC50 0.006Agonist activity at human PPARgamma expressed in african green monkey CV1 cells by Gal4 transactivation assay [AID459526, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
3
[SID103391063]
EC50 0.006Agonist activity at human PPARgamma expressed in african green monkey CV1 cells by Gal4 transactivation assay [AID459526, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
4
[SID103391063]
EC50 0.006Agonist activity at human PPARgamma expressed in african green monkey CV1 cells by Gal4 transactivation assay [AID459526, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
5
[SID103391063]
EC50 0.006Agonist activity at human PPARgamma expressed in african green monkey CV1 cells by Gal4 transactivation assay [AID459526, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
6
[SID103391063]
EC50 0.0062Agonist activity for Human PPAR gamma receptor in transcriptional activation assay [AID91246, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
7
[SID103391063]
EC50 0.0062Agonist activity for Human PPAR gamma receptor in transcriptional activation assay [AID91246, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
8
[SID103391063]
EC50 0.0062Agonist activity for Human PPAR gamma receptor in transcriptional activation assay [AID91246, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
9
[SID103391063]
EC50 0.0062Agonist activity for Human PPAR gamma receptor in transcriptional activation assay [AID91246, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
View
10
[SID103391063]
EC50 0.013Agonist activity for murine PPAR gamma receptor in transcriptional activation assay [AID141913, Type: other]Peroxisome proliferator-activated receptor gamma [gi:13432235]
View
11
[SID103391063]
EC50 0.013Agonist activity at mouse PPARgamma expressed in african green monkey CV1 cells by Gal4 transactivation assay [AID459534, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
View
12
[SID103391063]
EC50 0.026Binding affinity to PPARgamma LBD by fluorescence polarization based competitive binding assay [AID675850, Type: Literature]
View
13
[SID11114172]
Potency 0.0316qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
View
14
[SID11111229]
Potency 1.9953qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
View
15
[SID11111229]
Potency 1.9953qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
View
16
[SID11111229]
Potency 1.9953qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
View
17
[SID103391063]
IC50 2.953DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) [AID625229, Type: other]Thromboxane-A synthase [gi:254763392]
View
18
[SID103391063]
IC50 3.209DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) [AID625161, Type: other]Delta-type opioid receptor [gi:311033488]
View
19
[SID103391063]
IC50 3.209DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) [AID625161, Type: other]Delta-type opioid receptor [gi:311033488]
View
20
[SID11114172]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
View
21
[SID11114172]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
View
22
[SID103391063]
IC50 4DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: other]Cytochrome P450 2C9 [gi:6686268]
View
23
[SID103391063]
IC50 4DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: other]Cytochrome P450 2C9 [gi:6686268]
View
24
[SID103391063]
IC50 4DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: other]Cytochrome P450 2C9 [gi:6686268]
View
25
[SID103391063]
IC50 7.45DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625166, Type: other]
View
26
[SID103391063]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
View
27
[SID50104927]
Potency 8.9125qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
View
28
[SID50104927]
Potency 8.9125qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
View
29
[SID103391063]
IC50 10Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
View
30
[SID103391063]
IC50 10Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
View
31
[SID11111229]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
View
32
[SID11111229]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
View
33
[SID11111229]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
View
34
[SID103391063]
IC50 10.896DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: other]Epidermal growth factor receptor [gi:2811086]
View
35
[SID103391063]
IC50 10.896DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: other]Epidermal growth factor receptor [gi:2811086]
View
36
[SID103391063]
IC50 10.896DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: other]Epidermal growth factor receptor [gi:2811086]
View
37
[SID103391063]
IC50 10.91DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) [AID625145, Type: other]Cysteinyl leukotriene receptor 1 [gi:20138087]
View
38
[SID103391063]
IC50 10.91DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) [AID625145, Type: other]Cysteinyl leukotriene receptor 1 [gi:20138087]
View
39
[SID103391063]
IC50 13.551DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: other]Sodium-dependent dopamine transporter [gi:266667]
View
40
[SID103391063]
IC50 13.551DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: other]Sodium-dependent dopamine transporter [gi:266667]
View
41
[SID103391063]
IC50 13.551DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: other]Sodium-dependent dopamine transporter [gi:266667]
View
42
[SID103391063]
IC50 13.551DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: other]Sodium-dependent dopamine transporter [gi:266667]
View
43
[SID103391063]
IC50 14.318DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: other]Adenosine receptor A [gi:1351831]
View
44
[SID103391063]
IC50 14.318DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: other]Adenosine receptor A [gi:1351831]
View
45
[SID103391063]
IC50 14.509DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) [AID625227, Type: other]Substance-K receptor [gi:229462950]
View
46
[SID103391063]
IC50 14.966DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: other]Adenosine receptor A [gi:231473]
View
47
[SID103391063]
IC50 14.966DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: other]Adenosine receptor A [gi:231473]
View
48
[SID103391063]
IC50 14.966DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: other]Adenosine receptor A [gi:231473]
View
49
[SID103391063]
IC50 19.36DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625165, Type: other]
View
50
[SID103391063]
IC50 19.903DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
View