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GW 1929 (CID 6518171) - Compound BioActivity Data
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BioActivity Outcomes:
Active(46)
 
 
Inactive(190)
 
 
Inconclusive(47)
 
 
Unspecified(147)
 
 
Top Targets:
7TM GPCR Srx(20)
 
 
 
 
 
p450(20)
 
 
 
 
 
7TM GPCR Srsx(15)
 
 
 
NR LBD PPAR(12)
 
 
 
 
PLN02808(7)
 
 
BioAssay Types:
Confirmatory(329)
 
 
 
 
 
Literature(58)
 
 
 
 
Screening(12)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(170)
 
 
 
 
 
IC50(119)
 
 
 
EC50(7)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 356    Data Row: 430   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103391063]
EC50 0.0037Displacement of pan-PPAR fluormone from PPARgamma LBD by TR-FRET based LanthaScreen assay [AID675851, Type: Literature]
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2
[SID103391063]
EC50 0.006Agonist activity at human PPARgamma expressed in african green monkey CV1 cells by Gal4 transactivation assay [AID459526, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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3
[SID103391063]
EC50 0.0062Agonist activity for Human PPAR gamma receptor in transcriptional activation assay [AID91246, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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4
[SID103391063]
EC50 0.013Agonist activity for murine PPAR gamma receptor in transcriptional activation assay [AID141913, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
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5
[SID103391063]
EC50 0.013Agonist activity at mouse PPARgamma expressed in african green monkey CV1 cells by Gal4 transactivation assay [AID459534, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
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6
[SID103391063]
EC50 0.026Binding affinity to PPARgamma LBD by fluorescence polarization based competitive binding assay [AID675850, Type: Literature]
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7
[SID11114172]
Potency 0.0316qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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8
[SID11111229]
Potency 1.9953qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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9
[SID103391063]
IC50 2.953DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) [AID625229, Type: confirmatory]Thromboxane-A synthase [gi:254763392]
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10
[SID103391063]
IC50 3.209DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) [AID625161, Type: confirmatory]Delta-type opioid receptor [gi:311033488]
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11
[SID11114172]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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12
[SID103391063]
IC50 4DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: confirmatory]Cytochrome P450 2C9 [gi:6686268]
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13
[SID103391063]
IC50 7.45DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625166, Type: confirmatory]
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14
[SID103391063]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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15
[SID50104927]
Potency 8.9125qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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16
[SID50104927]
Potency 8.9125qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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17
[SID103391063]
IC50 10Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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18
[SID103391063]
IC50 10Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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19
[SID11111229]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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20
[SID103391063]
IC50 10.896DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: confirmatory]Epidermal growth factor receptor [gi:2811086]
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