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epigallocatechin gallate (CID 65064) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(164)
 
 
Inactive(421)
 
 
Inconclusive(67)
 
 
Unspecified(249)
 
 
Top Targets:
NR LBD PPAR(27)
 
 
 
 
beta secretas..(22)
 
 
 
 
NR LBD AR(16)
 
 
 
 
NR LBD ER(16)
 
 
 
NR LBD TR(12)
 
 
 
 
BioAssay Types:
Literature(387)
 
 
 
 
 
Confirmatory(259)
 
 
 
 
Screening(171)
 
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(249)
 
 
 
 
IC50(107)
 
 
 
 
 
EC50(14)
 
 
 
 
 
Ki(5)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 773    Data Row: 901   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103226312]
Ki 0.008Inhibition of Plasmodium falciparum ENR in presence of triclosan [AID277587, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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2
[SID103226312]
Ki 0.028Competitive inhibition of Spiroplasma sp. MQ1 SssI methyltransferase using pUC18 as substrate measured for 10 mins by Dixon plot analysis [AID675175, Type: Literature]CPG DNA methylase [gi:417325]
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3
[SID103226312]
EC50 0.03987Neuroprotection against beta-amyloid peptide 1-42-induced toxicity in human SH-SY5Y cells assessed as lactate dehydrogenase release [AID392677, Type: Literature]
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4
[SID103226312]
Ki 0.079Inhibition of Plasmodium falciparum ENR using crotonyl-CoA substrate [AID277586, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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5
[SID103226312]
IC50 0.086Inhibition of chymotrypsin like activity of proteasome [AID461136, Type: Literature]
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6
[SID103226312]
IC50 0.18Inhibition of beta amyloid (1 to 40) fibril formation [AID456194, Type: Literature]
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7
[SID103226312]
Ki 0.186Inhibition of Plasmodium falciparum ENR using NADH substrate [AID277585, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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8
[SID103226312]
IC50 0.2Inhibition of FabI [AID265759, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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9
[SID103226312]
IC50 0.2Inhibition of chymotrypsin like activity of 20S proteasome [AID300029, Type: Literature]
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10
[SID103226312]
IC50 0.25Inhibition of Plasmodium falciparum ENR [AID277583, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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11
[SID103226312]
IC50 0.25Inhibition of yeast G6PD [AID319369, Type: Literature]Glucose-6-phosphate 1-dehydrogenase [gi:120734]
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12
[SID103226312]
IC50 0.3Inhibition of FabG [AID265760, Type: Literature]3-oxoacyl-acyl-carrier protein reductase precursor [gi:75020671]
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13
[SID103226312]
IC50 0.37Inhibition of tetrahymena telomerase using 3'-ACT TCG TAG AGC AGA TTG-5' as substrate incubated for 10 mins prior to extension reaction by telomeric repeat amplification protocol [AID704068, Type: Literature]
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14
[SID103226312]
EC50 0.391Antiviral activity against Influenza (A/PR8/34(H1N1)) [AID343516, Type: Literature]
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15
[SID103226312]
IC50 0.4Inhibition of FabZ [AID265758, Type: Literature]Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) [gi:74844869]
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16
[SID26719730]
Potency 0.4467qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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17
[SID103226312]
IC50 0.69Inhibition of rat squalene epoxidase [AID357310, Type: Literature]Squalene monooxygenase [gi:1706689]
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18
[SID103226312]
IC50 0.69Compound was evaluated for its inhibitory activity against recombinant rat SE(squalene epoxidase) [AID204664, Type: Literature]
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19
[SID103226312]
IC50 0.72Inhibition of 6PGD [AID319370, Type: Literature]
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20
[SID49681655]
EC50 0.727Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of Mex-5 Binding to TCR-2 [AID1960, Type: confirmatory]Zinc finger protein mex-5 [gi:55976631]
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21
[SID103226312]
IC50 0.73Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]dGTP [AID83435, Type: Literature]Reverse transcriptase/RNaseH [gi:82310930]
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22
[SID103226312]
IC50 0.757Inhibition of recombinant human BACE1 using Eu-CEVNLDAEFK-Qsy7 as substrate by HTRF assay [AID646974, Type: Literature]Beta-secretase 1 [gi:296434407]
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23
[SID26719730]
Potency 0.8913qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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24
[SID103226312]
IC50 1Inhibition of telomerase in human U937 cells [AID704071, Type: Literature]Telomerase reverse transcriptase [gi:6226780]
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25
[SID103226312]
IC50 1.08Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction followed by compound washout by spin-telomeric repeat amplification protocol [AID704077, Type: Literature]Telomerase reverse transcriptase [gi:6226780]
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26
[SID103226312]
IC50 1.18Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by telomeric repeat amplification protocol [AID704076, Type: Literature]Telomerase reverse transcriptase [gi:6226780]
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27
[SID103226312]
IC50 1.6Inhibition of BACE1 using Rh-EVNLDAEFK-Quencher as substrate [AID647157, Type: Literature]
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28
[SID26719730]
Potency 1.7783qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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29
[SID103226312]
IC50 2.21Inhibition of p38alpha after 1 hr by ELISA [AID566611, Type: Literature]
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30
[SID103226312]
IC50 3Inhibition of KDM4E [AID639775, Type: Literature]
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31
[SID26719730]
Potency 3.1623qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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32
[SID103226312]
IC50 3.2Cytotoxicity against CHO cells expressing OATP1B3 haplotype 1 after 48 hrs by fluorescence based CellTiter-Glo assay [AID729671, Type: Literature]
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33
[SID103226312]
Ki 3.3Inhibition of MET kinase by Dixon plot analysis [AID437511, Type: Literature]
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34
[SID103226312]
IC50 3.7Inhibition of reduced carboxymethylated kappa-casein fibril formation measured every 5 mins after 1000 mins by thioflavin T staining-based binding assay [AID456187, Type: Literature]
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35
[SID103226312]
IC50 6.29Inhibition of rat liver microsomal Steroid 5-alpha-reductase after 30 mins by scintillation counting [AID548975, Type: Literature]
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36
[SID103226312]
IC50 6.44Inhibition of IDH [AID319371, Type: Literature]
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37
[SID103226312]
IC50 6.8Inhibition of human recombinant MT1-MMP expressed in Escherichia coli by fluorogenic peptide cleavage assay [AID428320, Type: Literature]Matrix metalloproteinase-14 [gi:317373419]
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38
[SID103226312]
ED50 7Antioxidant activity assessed as DPPH radical scavenging activity [AID365747, Type: Literature]
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39
[SID103226312]
ED50 7Antioxidant activity assessed as radical DPPH scavenging activity [AID429185, Type: Literature]
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40
[SID103226312]
IC50 7.7Cytotoxicity against CHO cells expressing OATP1B1*1b after 48 hrs by fluorescence based CellTiter-Glo assay [AID729672, Type: Literature]
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41
[SID103226312]
IC50 8.3Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometry [AID650645, Type: Literature]
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42
[SID103226312]
ED50 8.3Antiviral activity against influenza A virus (A/swine/OH/511445/2007(H1N1)) Oh7 infected in MDCK cells assessed as inhibition of viral replication after 4 days by quantitative RT-PCR [AID638568, Type: Literature]
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43
[SID26719730]
Potency 8.9125qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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44
[SID26719730]
Potency 8.9125qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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45
[SID103226312]
IC50 9.4Inhibition of lipid peroxidation in Sprague-Dawley rat heart mitochondria assessed as inhibition of FeSO4-induced malondialdehyde formation [AID398697, Type: Literature]
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46
[SID103226312]
IC50 9.4Antiproliferative activity against human HL60 cells after 3 days [AID363881, Type: Literature]
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47
[SID103226312]
IC50 9.6Inhibition of human recombinant MMP2 expressed in Escherichia coli by fluorogenic peptide cleavage assay [AID428322, Type: Literature]72 kDa type IV collagenase [gi:116856]
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48
[SID103226312]
IC50 9.9Antifibrotic activity against rat HSC-T6 cells assessed as inhibition of proliferation after 48 hrs by BrdU incorporation assay [AID597201, Type: Literature]
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49
[SID103226312]
IC50 9.9Antiproliferative activity against rat HSC-T6 cells after 48 hrs by MTT assay [AID312043, Type: Literature]
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50
[SID103226312]
IC50 9.9Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 [AID265762, Type: Literature]
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