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epigallocatechin gallate (CID 65064) - Compound BioActivity Data
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BioActivity Outcomes:
Active(192)
 
 
Inactive(435)
 
 
Inconclusive(65)
 
 
Unspecified(304)
 
 
Top Targets:
NR LBD PPAR(27)
 
 
 
beta secretas..(22)
 
 
 
 
NR LBD AR(16)
 
 
 
 
7tm 4(16)
 
 
NR LBD ER(16)
 
 
 
BioAssay Types:
Literature(448)
 
 
 
 
 
Confirmatory(261)
 
 
 
 
 
Screening(171)
 
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(249)
 
 
 
 
IC50(124)
 
 
 
 
 
EC50(18)
 
 
 
 
 
Kd(6)
 
 
Ki(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 864    Data Row: 996   Total Pages: 50   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103226312]
Ki 0.008Inhibition of Plasmodium falciparum ENR in presence of triclosan [AID277587, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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2
[SID103226312]
Ki 0.028Competitive inhibition of Spiroplasma sp. MQ1 SssI methyltransferase using pUC18 as substrate measured for 10 mins by Dixon plot analysis [AID675175, Type: Literature]CPG DNA methylase [gi:417325]
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3
[SID103226312]
IC50 0.03Inhibition of recombinant Plasmodium falciparum FabZ using crotonoyl-CoA as substrate after 10 mins [AID771680, Type: Literature]Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) [gi:74844869]
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4
[SID103226312]
EC50 0.03987Neuroprotection against beta-amyloid peptide 1-42-induced toxicity in human SH-SY5Y cells assessed as lactate dehydrogenase release [AID392677, Type: Literature]
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5
[SID103226312]
Ki 0.079Inhibition of Plasmodium falciparum ENR using crotonyl-CoA substrate [AID277586, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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6
[SID103226312]
IC50 0.086Inhibition of chymotrypsin like activity of proteasome [AID461136, Type: Literature]
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7
[SID103226312]
IC50 0.18Inhibition of beta amyloid (1 to 40) fibril formation [AID456194, Type: Literature]
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8
[SID103226312]
Ki 0.186Inhibition of Plasmodium falciparum ENR using NADH substrate [AID277585, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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9
[SID103226312]
IC50 0.2Inhibition of FabI [AID265759, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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10
[SID103226312]
IC50 0.2Inhibition of chymotrypsin like activity of 20S proteasome [AID300029, Type: Literature]
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11
[SID103226312]
IC50 0.25Inhibition of yeast G6PD [AID319369, Type: Literature]Glucose-6-phosphate 1-dehydrogenase [gi:120734]
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12
[SID103226312]
IC50 0.25Inhibition of Plasmodium falciparum ENR [AID277583, Type: Literature]Enoyl-acyl-carrier protein reductase precursor [gi:74844868]
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13
[SID103226312]
IC50 0.3Inhibition of FabG [AID265760, Type: Literature]3-oxoacyl-acyl-carrier protein reductase precursor [gi:75020671]
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14
[SID103226312]
IC50 0.32Inhibition of recombinant Plasmodium falciparum 3D7 FabG using acetoacetyl-CoA as substrate after 10 mins in presence of NADPH [AID771681, Type: Literature]3-oxoacyl-(Acyl-carrier protein) reductase, putative [gi:75015131]
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15
[SID103226312]
IC50 0.33Inhibition of human GST-fused DYRK1A expressed in Escherichia coli using KISGRLSPIMTEQ as substrate [AID1062363, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 1A [gi:3219996]
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16
[SID103226312]
Ki 0.335Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assay [AID1095217, Type: confirmatory]Apoptosis regulator Bcl-2 [gi:231632]
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17
[SID103226312]
IC50 0.37Inhibition of tetrahymena telomerase using 3'-ACT TCG TAG AGC AGA TTG-5' as substrate incubated for 10 mins prior to extension reaction by telomeric repeat amplification protocol [AID704068, Type: Literature]
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18
[SID103226312]
EC50 0.391Antiviral activity against Influenza (A/PR8/34(H1N1)) [AID343516, Type: Literature]
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19
[SID103226312]
IC50 0.4Inhibition of FabZ [AID265758, Type: Literature]Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) [gi:74844869]
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20
[SID26719730]
Potency 0.4467qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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