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MLS000076121 (CID 650462) - Compound BioActivity Data
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BioActivity Outcomes:
Active(140)
 
 
Inactive(718)
 
 
Inconclusive(51)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(27)
 
 
 
7TM GPCR Srsx(22)
 
 
 
Bcl-2 like(14)
 
 
 
alkPPc(14)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(594)
 
 
 
 
Confirmatory(276)
 
 
 
 
 
Literature(12)
 
 
 
BioActivity Types:
Potency(173)
 
 
 
 
 
IC50(57)
 
 
 
 
EC50(18)
 
 
 
 
AC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 832    Data Row: 910   Total Pages: 46   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID848038]
Potency 0.2993qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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2
[SID848038]
Potency 0.5645qHTS Fluorescence Polarization (FP) Assay for Inhibitors of MLL CXXC domain - DNA interaction: Fluorescein FP [AID624160, Type: confirmatory]
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3
[SID848038]
IC50 0.61948Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput counterscreen to identify inhibitors of TEM-1 metallo-beta-lactamase [AID2755, Type: confirmatory]Beta lactamase [Pseudomonas aeruginosa] [gi:114881106]
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4
[SID85303865]
AC50_uM 0.786C-LANA Counter Screen: DNA intercalators Measured in Biochemical System Using Plate Reader - 2117-02_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504727, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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5
[SID85303865]
AC50_uM 1.109C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity [AID504725, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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6
[SID848038]
IC50 1.392Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase [AID2754, Type: confirmatory]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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7
[SID848038]
Potency 1.5849qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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8
[SID848038]
IC50 1.622Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase [AID2756, Type: confirmatory]metallo-beta-lactamase IMP-1 [Pseudomonas aeruginosa] [gi:27368096]
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9
[SID848038]
IC50 4.455Tumor Hsp90 Inhibitors Dose Response Confirmation [AID712, Type: confirmatory]90-kda heat shock protein beta HSP90 beta [Homo sapiens] [gi:4261762]
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10
[SID848038]
IC50 4.455Tumor Hsp90 Inhibitors Dose Response Confirmation [AID712, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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11
[SID848038]
Potency 4.4668Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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12
[SID848038]
EC50 4.58HCS for Compounds that Up-Regulate Insulin Promoter Activity in MIN6 Cells [AID1625, Type: confirmatory]
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13
[SID848038]
Potency 11.2202qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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14
[SID848038]
Potency 12.5893qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1: Spectroscopic Profiling in AFC Spectral Region [AID923, Type: confirmatory]
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15
[SID848038]
Potency 19.9526qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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16
[SID848038]
Potency 22.3872qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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17
[SID131280334]
IC50 25Competitive inhibition of human ASK1 [AID593712, Type: Literature]Mitogen-activated protein kinase kinase kinase 5 [gi:6685617]
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18
[SID848038]
Potency 25.1189qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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19
[SID848038]
Potency 28.1838qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720707, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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20
[SID848038]
Potency 31.6228qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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