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baicalin (CID 64982) - Compound BioActivity Data
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BioActivity Outcomes:
Active(23)
 
 
Inactive(3)
 
 
Unspecified(50)
 
 
Top Targets:
Peptidase S9(8)
 
 
 
KAZAL SLC21(3)
 
 
ABCC MRP doma..(2)
 
 
NR LBD ER(2)
 
 
7tm 4(1)
 
 
BioAssay Types:
Literature(76)
 
 
 
 
BioActivity Types:
IC50(7)
 
 
 
Ki(2)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 76    Data Row: 76   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103581449]
ID50 3Antiinflammatory activity in Wistar rat peritoneal mast cells assessed as inhibition of concanavalin A-induced histamine release treated 10 mins before concanavalin A challenge measured after 30 mins [AID338667, Type: Literature]
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2
[SID103581449]
IC50 12Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli [AID365674, Type: Literature]Prolyl endopeptidase [gi:215273868]
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3
[SID103581449]
IC50 12.3Inhibition of human recombinant POP [AID481401, Type: Literature]Prolyl endopeptidase [gi:215273868]
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4
[SID103581449]
IC50 14.36Inhibition of Cdk1/cyclin B [AID365954, Type: Literature]
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5
[SID103581449]
Antiproliferative activity against human HL60 cells at 30 uM after 48 hrs by MTS assay [AID381804, Type: Literature]
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6
[SID103581449]
Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as decrease of IL-6 mRNA expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by RT-PCR analysis [AID566746, Type: Literature]
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7
[SID103581449]
Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of COX2 mRNA expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by RT-PCR analysis [AID566748, Type: Literature]
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8
[SID103581449]
Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of iNOS protein expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by Western blot analysis [AID566750, Type: Literature]
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9
[SID103581449]
Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of COX2 protein expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by Western blot analysis [AID566751, Type: Literature]
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10
[SID103581449]
Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of HO-1 mRNA expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by RT-PCR analysis [AID566752, Type: Literature]
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11
[SID103581449]
Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of HO-1 protein expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by Western blot analysis [AID566753, Type: Literature]
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12
[SID103581449]
Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of nuclear localization of NF-kappaB/p65 subunit in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by Western blot analysis [AID566754, Type: Literature]
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13
[SID103581449]
Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of degradation of IkappaB-alpha in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by Western blot analysis [AID566755, Type: Literature]
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14
[SID103581449]
Hepatoprotective activity in Sprague-Dawley rat ischemia-reperfusion model assessed as decrease of mitochondrial swelling in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia relative to control [AID566756, Type: Literature]
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15
[SID103581449]
Hepatoprotective activity in Sprague-Dawley rat ischemia-reperfusion model assessed as decrease of caspase 3 activity in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by Western blot analysis relative to control [AID566757, Type: Literature]
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16
[SID103581449]
Hepatoprotective activity in Sprague-Dawley rat ischemia-reperfusion model assessed as decrease of caspase 8 activity in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by Western blot analysis relative to control [AID566758, Type: Literature]
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17
[SID103581449]
Hepatoprotective activity in Sprague-Dawley rat ischemia-reperfusion model assessed as decrease of TRADD protein expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by Western blot analysis [AID566759, Type: Literature]
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18
[SID103581449]
Hepatoprotective activity in Sprague-Dawley rat ischemia-reperfusion model assessed as protection against apoptosis in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by TUNEL assay [AID566760, Type: Literature]
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19
[SID103581449]
Hepatoprotective activity in Sprague-Dawley rat sham operated model assessed as decrease of mitochondrial swelling in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia relative to control [AID566761, Type: Literature]
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20
[SID103581449]
Hepatoprotective activity in Sprague-Dawley rat sham operated model assessed as decrease of caspase 3 activity in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by Western blot analysis relative to control [AID566762, Type: Literature]
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