baicalin (CID 64982) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(23)
 
 
Inactive(3)
 
 
Unspecified(47)
 
 
Top Targets:
Peptidase S9(8)
 
 
 
NR LBD ER(2)
 
 
ABCC MRP doma..(1)
 
 
BioAssay Types:
Literature(68)
 
 
 
 
BioActivity Types:
IC50(7)
 
 
 
Ki(2)
 
 
EC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 73    Data Row: 73   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103581449]
ID50 3Antiinflammatory activity in Wistar rat peritoneal mast cells assessed as inhibition of concanavalin A-induced histamine release treated 10 mins before concanavalin A challenge measured after 30 mins [AID338667, Type: other]
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2
[SID103581449]
IC50 12Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli [AID365674, Type: Literature]Prolyl endopeptidase [gi:215273868]
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3
[SID103581449]
IC50 12Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli [AID365674, Type: Literature]Prolyl endopeptidase [gi:215273868]
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4
[SID103581449]
IC50 12.3Inhibition of human recombinant POP [AID481401, Type: Literature]Prolyl endopeptidase [gi:215273868]
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5
[SID103581449]
IC50 12.3Inhibition of human recombinant POP [AID481401, Type: Literature]Prolyl endopeptidase [gi:215273868]
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6
[SID103581449]
IC50 14.36Inhibition of Cdk1/cyclin B [AID365954, Type: Literature]
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7
[SID103581449]
 Antiproliferative activity against human HL60 cells at 30 uM after 48 hrs by MTS assay [AID381804, Type: Literature]
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8
[SID103581449]
 Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of iNOS protein expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by western blot analysis [AID566750, Type: Literature]
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9
[SID103581449]
 Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of COX2 protein expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by western blot analysis [AID566751, Type: Literature]
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10
[SID103581449]
 Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of HO-1 mRNA expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by RT-PCR analysis [AID566752, Type: Literature]
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11
[SID103581449]
 Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of HO-1 protein expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by western blot analysis [AID566753, Type: Literature]
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12
[SID103581449]
 Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of nuclear localization of NF-kappaB/p65 subunit in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by western blot analysis [AID566754, Type: Literature]
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13
[SID103581449]
 Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of degradation of IkappaB-alpha in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by western blot analysis [AID566755, Type: Literature]
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14
[SID103581449]
 Hepatoprotective activity in Sprague-Dawley rat ischemia-reperfusion model assessed as decrease of mitochondrial swelling in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia relative to control [AID566756, Type: Literature]
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15
[SID103581449]
 Hepatoprotective activity in Sprague-Dawley rat ischemia-reperfusion model assessed as decrease of caspase 3 activity in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by western blot analysis relative to control [AID566757, Type: Literature]
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16
[SID103581449]
 Hepatoprotective activity in Sprague-Dawley rat ischemia-reperfusion model assessed as decrease of caspase 8 activity in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by western blot analysis relative to control [AID566758, Type: Literature]
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17
[SID103581449]
 Hepatoprotective activity in Sprague-Dawley rat ischemia-reperfusion model assessed as decrease of TRADD protein expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by western blot analysis [AID566759, Type: Literature]
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18
[SID103581449]
 Hepatoprotective activity in Sprague-Dawley rat ischemia-reperfusion model assessed as protection against apoptosis in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by TUNEL assay [AID566760, Type: Literature]
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19
[SID103581449]
 Hepatoprotective activity in Sprague-Dawley rat sham operated model assessed as decrease of mitochondrial swelling in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia relative to control [AID566761, Type: Literature]
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20
[SID103581449]
 Hepatoprotective activity in Sprague-Dawley rat sham operated model assessed as decrease of caspase 3 activity in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by western blot analysis relative to control [AID566762, Type: Literature]
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21
[SID103581449]
 Hepatoprotective activity in Sprague-Dawley rat sham operated model assessed as decrease of caspase 8 activity in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by western blot analysis relative to control [AID566763, Type: Literature]
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22
[SID103581449]
 Binding affinity to hen egg white lysozyme assessed as reduction in fluorescence intensity at 1 to 7 x 10'-6 M at 310 K [AID629620, Type: Literature]
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23
[SID103581449]
 Binding affinity to hen egg white lysozyme assessed as reduction in fluorescence intensity at 1 to 7 x 10'-6 M at 298 K [AID629621, Type: Literature]
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24
[SID103581449]
 Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as decrease of IL-6 mRNA expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by RT-PCR analysis [AID566746, Type: Literature]
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25
[SID103581449]
 Antiinflammatory activity in Sprague-Dawley rat ischemia-reperfusion model assessed as inhibition of COX2 mRNA expression in liver tissue at 200 mg/kg, ip administered 24 hrs and 1 hr before ischemia by RT-PCR analysis [AID566748, Type: Literature]
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26
[SID103581449]
Ki 7.95TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat [AID681175, Type: other]Canalicular multispecific organic anion transporter 1 [gi:3219824]
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27
[SID103581449]
IC50 72Cytotoxicity against human H9 cells after 3 days [AID332930, Type: other]
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28
[SID103581449]
Ki 77.6247Binding affinity towards benzodiazepine site in GABAA receptor [AID72729, Type: Literature]
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29
[SID103581449]
EC50 112Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay [AID332929, Type: other]
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30
[SID103581449]
IC50 200Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells [AID355721, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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31
[SID103581449]
IC50 200Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells [AID355721, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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32
[SID103581449]
IC50 200Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells [AID355721, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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33
[SID103581449]
IC50 225Inhibition of DPP4 [AID365675, Type: Literature]
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34
[SID103581449]
IC50 1000Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA [AID403947, Type: Literature]
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35
[SID103581449]
 Inhibition of human prolyl oligopeptidase at 50 uM preincubated for 15 mins [AID365680, Type: Literature]Prolyl endopeptidase [gi:215273868]
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36
[SID103581449]
 Inhibition of human prolyl oligopeptidase at 50 uM preincubated for 15 mins [AID365680, Type: Literature]Prolyl endopeptidase [gi:215273868]
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37
[SID103581449]
 Inhibition of human prolyl oligopeptidase at 50 uM preincubated for 30 mins [AID365681, Type: Literature]Prolyl endopeptidase [gi:215273868]
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38
[SID103581449]
 Inhibition of human prolyl oligopeptidase at 50 uM preincubated for 30 mins [AID365681, Type: Literature]Prolyl endopeptidase [gi:215273868]
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39
[SID103581449]
 Antibacterial activity against Staphylococcus aureus in presence of 25 mg/L lysozyme [AID629632, Type: Literature]
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40
[SID103581449]
 Antibacterial activity against Staphylococcus aureus [AID629630, Type: Literature]
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41
[SID103581449]
 Effect on human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesicles relative to control [AID404304, Type: Literature]Canalicular multispecific organic anion transporter 1 [gi:308153583]
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42
[SID103581449]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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43
[SID103581449]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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44
[SID103581449]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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45
[SID103581449]
 Estrogenic activity at ERalpha in human MVLN cells at 100 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642414, Type: Literature]Estrogen receptor [gi:544257]
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46
[SID103581449]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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47
[SID103581449]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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48
[SID103581449]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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49
[SID103581449]
 Estrogenic activity at ERalpha in human MVLN cells at 20 ug/mL after 24 hrs by luciferase reporter gene assay relative to E2 [AID642415, Type: Literature]Estrogen receptor [gi:544257]
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50
[SID103581449]
 Permeability across polyvinylidenefluoride membrane coated with polar brain lipid extract porcine by BBB PAMPA [AID365683, Type: Literature]
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