Bookmark and Share
ursolic acid (CID 64945) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(148)
 
 
Inactive(621)
 
 
Inconclusive(15)
 
 
Unspecified(205)
 
 
Top Targets:
PTPc(29)
 
 
 
 
 
7TM GPCR Srx(21)
 
 
NR LBD PPAR(17)
 
 
 
 
7TM GPCR Srsx(12)
 
 
G-alpha(7)
 
 
 
BioAssay Types:
Screening(414)
 
 
 
 
Literature(379)
 
 
 
 
 
Confirmatory(188)
 
 
 
 
 
BioActivity Types:
IC50(149)
 
 
 
 
 
Potency(134)
 
 
 
 
 
EC50(14)
 
 
 
 
 
Ki(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 935    Data Row: 989   Total Pages: 20   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103350986]
IC50 0.0025Inhibitory activity against group II Phospholipase A2 (PLA2) from Vipera russelli russelli venom [AID158766, Type: Literature]
View
2
[SID103350986]
ID50 0.14Antiinflammatory activity against croton oil-induced ear edema in mouse [AID380766, Type: Literature]
View
3
[SID56463656]
Potency 0.3162qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
View
4
[SID26725260]
Potency 0.4992Concentration response confirmation assay for inhibitors of ROR gamma transcriptional activity [AID2762, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
5
[SID26725260]
Potency 0.7079qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
6
[SID26725260]
EC50 0.88Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
View
7
[SID26725260]
EC50 0.949Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
View
8
[SID103350986]
IC50 1Antimicrobial activity against Toxoplasma gondii [AID496824, Type: Literature]
View
9
[SID103350986]
EC50 1.43Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay [AID444761, Type: Literature]
View
10
[SID26725260]
EC50 1.79Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
View
11
[SID103350986]
IC50 1.8Cytotoxicity against human WI 38 cells after 48 hrs by WST-8 assay [AID377096, Type: Literature]
View
12
[SID103350986]
IC50 1.9Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as reduction of cortisone to cortisol conversion by scintillation counting [AID458318, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:118569]
View
13
[SID103350986]
Ki 2Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation [AID697012, Type: Literature]Aldo-keto reductase family 1 member B10 [gi:322510010]
View
14
[SID103350986]
Ki 2.1Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 V301L mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation [AID697014, Type: Literature]
View
15
[SID103350986]
IC50 2.2Antitrypanosomal activity against Trypanosoma brucei brucei bloodstream trypomastigotes by alamar blue assay [AID311138, Type: Literature]
View
16
[SID103350986]
IC50 2.3In vitro inhibitory concentration against phospholipase A2 of Echis carinatus venom [AID241486, Type: Literature]Acidic phospholipase A2 EC-I [gi:82096307]
View
17
[SID103350986]
IC50 2.3Inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr [AID687539, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
18
[SID103350986]
IC50 2.4Inhibition of TCPTP (unknown origin) assessed as decrease in p-nitrophenol production from pNPP substrate after 30 mins by HTS7000 bioassay reader analysis [AID729839, Type: Literature]Tyrosine-protein phosphatase non-receptor type 2 [gi:229462762]
View
19
[SID103350986]
IC50 2.5In vitro inhibitory concentration against phospholipase A2 of Trimeresurus flavoviridis venom [AID241811, Type: Literature]Basic phospholipase A2 PLA-A [gi:28202237]
View
20
[SID103350986]
IC50 2.5In vitro Inhibitory concentration against phospholipase A2 activity of synovial fluid [AID241283, Type: Literature]
View
21
[SID103350986]
IC50 2.5Inhibition of PTP1B mediated pNPP hydrolysis [AID469324, Type: Literature]
View
22
[SID103350986]
IC50 2.75Inhibition of PTP1B (unknown origin) assessed as decrease in p-nitrophenol production from pNPP substrate after 30 mins by HTS7000 bioassay reader analysis [AID729840, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
23
[SID103350986]
Ki 2.8Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 K125L mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation [AID697013, Type: Literature]
View
24
[SID103350986]
IC50 2.9In vitro inhibitory concentration against phospholipase A2 of Naja melanoleuca venom [AID241513, Type: Literature]Basic phospholipase A2 1 [gi:129409]
View
25
[SID103350986]
IC50 3.08Inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate after 30 mins by spectrophotometric analysis [AID719063, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
26
[SID103350986]
IC50 3.08Inhibition of PTP1B [AID424242, Type: Literature]
View
27
[SID103350986]
IC50 3.08Inhibition of PTP1B by pNPP assay [AID409686, Type: Literature]
View
28
[SID103350986]
IC50 3.1Growth inhibition of mouse B16 2F2 cells after 3 days [AID334272, Type: Literature]
View
29
[SID103350986]
IC50 3.1Inhibition of human recombinant PTP1B after 30 mins [AID391031, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
30
[SID103350986]
IC50 3.1Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate after 30 mins [AID598810, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
31
[SID103350986]
IC50 3.1Inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate assessed as p-nitrophenol release after 30 mins [AID683328, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
32
[SID103350986]
IC50 3.33Inhibition of TCPTP by pNPP assay [AID409687, Type: Literature]
View
33
[SID103350986]
IC50 3.4Inhibition of PTP1B using p-nitrophenyl phosphate as substrate [AID615386, Type: Literature]
View
34
[SID103350986]
Ki 3.4Mixed type inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate [AID687544, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
35
[SID103350986]
IC50 3.5Toxicity against human dermal fibroblasts [AID396439, Type: Literature]
View
36
[SID103350986]
IC50 3.6Inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate after 30 mins [AID695959, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
37
[SID103350986]
IC50 3.6Inhibition of human recombinant PTP1B assessed as p-nitorphenol production after 30 mins [AID612168, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
38
[SID103350986]
IC50 3.6Inhibition of human recombinant PTP1B [AID288630, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
39
[SID103350986]
IC50 3.6Inhibition of human recombinant PTP1B [AID347889, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
40
[SID103350986]
IC50 3.6Inhibition of human recombinant PTP1B [AID379219, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
41
[SID103350986]
IC50 3.6Inhibition of human recombinant PTP1B assessed as p-nitrophenol production [AID467753, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
42
[SID103350986]
Ki 3.7Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 Q303S mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation [AID697015, Type: Literature]
View
43
[SID103350986]
IC50 3.8Inhibition of human recombinant LAR expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr [AID687543, Type: Literature]Receptor-type tyrosine-protein phosphatase F [gi:226709091]
View
44
[SID103350986]
IC50 3.8Inhibition of human recombinant PTP1B [AID445607, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
45
[SID103350986]
IC50 3.9Inhibition of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phosphate after 30 mins [AID447165, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
View
46
[SID103350986]
IC50 4Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction [AID697009, Type: Literature]Aldo-keto reductase family 1 member B10 [gi:322510010]
View
47
[SID103350986]
IC50 4Antitrypanosomal activity against Trypanosoma cruzi amastigote forms [AID395317, Type: Literature]
View
48
[SID103350986]
IC50 4Antitrypanosomal activity against Trypanosoma cruzi Tulahuen CL2 by microdilution method [AID333387, Type: Literature]
View
49
[SID103350986]
IC50 4Antitrypanosomal activity against Trypanosoma brucei S427 by microdilution method [AID333388, Type: Literature]
View
50
[SID103350986]
EC50 4.4Cytotoxicity against mock-infected human H9 cells [AID378287, Type: Literature]
View