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BioActivity Data for Compound ursolic acid (CID 64945)

BioActivity Outcomes:
Active(164)
 
 
Inactive(632)
 
 
Inconclusive(15)
 
 
Unspecified(318)
 
 
Top Targets:
7tm 4(34)
 
 
PTPc(31)
 
 
 
 
 
NR LBD PPAR(17)
 
 
 
 
NR LBD ROR li..(10)
 
 
 
 
Tryp SPc(7)
 
 
BioAssay Types:
Literature(477)
 
 
 
 
 
Screening(415)
 
 
 
 
Confirmatory(194)
 
 
 
 
 
BioAssay Categories:
In vitro(9)
 
 
 
In vivo(1)
 
 
Biochemical(245)
 
 
 
 
 
Toxicity(92)
 
 
 
 
ADME(40)
 
 
 
Cell-based(339)
 
 
 
 
Organism-base..(16)
 
 
 
 
BioActivity Types:
IC50(167)
 
 
 
 
 
Potency(134)
 
 
 
 
 
EC50(14)
 
 
 
 
 
Ki(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1068    Data Row: 1129   Total Pages: 57   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103350986]
IC50 0.0025Inhibitory activity against group II Phospholipase A2 (PLA2) from Vipera russelli russelli venom [AID158766, Type: Literature]
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2
[SID103350986]
IC50 0.13Antagonist activity at Gal4-fused RORgamma (unknown origin) expressed in 293T cells after 24 hrs by luciferase reporter gene assay [AID1127096, Type: Literature]Nuclear receptor ROR-gamma [gi:49066040]
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3
[SID103350986]
ID50 0.14Antiinflammatory activity against croton oil-induced ear edema in mouse [AID380766, Type: Literature]
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4
[SID56463656]
Potency 0.3162qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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5
[SID26725260]
Potency 0.4992Concentration response confirmation assay for inhibitors of ROR gamma transcriptional activity [AID2762, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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6
[SID103350986]
IC50 0.68Inhibition of human GST-tagged ROR gamma LBD (amino acids 250 to 518)/LxxLL motif containing SRC1 derived peptide (unknown origin) interaction by TR-FRET assay [AID1121411, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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7
[SID26725260]
Potency 0.7079qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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8
[SID26725260]
EC50 0.88Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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9
[SID26725260]
EC50 0.949Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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10
[SID103350986]
IC50 1Antimicrobial activity against Toxoplasma gondii [AID496824, Type: Literature]
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11
[SID103350986]
IC50 1.06Antagonist activity at full-length RORgamma (unknown origin) expressed in 293T cells after 24 hrs by luciferase reporter gene assay [AID1127097, Type: Literature]Nuclear receptor ROR-gamma [gi:49066040]
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12
[SID103350986]
EC50 1.43Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay [AID444761, Type: Literature]
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13
[SID103350986]
IC50 1.78Inhibition of alpha-glucosidase (unknown origin) using PNPG as substrate incubated for 15 min prior to substrate addition measured after 15 min by spectrophotometric analysis [AID1095894, Type: confirmatory]
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14
[SID26725260]
EC50 1.79Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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15
[SID103350986]
IC50 1.8Cytotoxicity against human WI 38 cells after 48 hrs by WST-8 assay [AID377096, Type: Literature]
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16
[SID103350986]
IC50 1.9Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as reduction of cortisone to cortisol conversion by scintillation counting [AID458318, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:118569]
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17
[SID103350986]
Ki 2Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation [AID697012, Type: Literature]Aldo-keto reductase family 1 member B10 [gi:322510010]
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18
[SID103350986]
Ki 2.1Competitive inhibition of dehydrogenase activity of N-terminal 6His-tagged human AKR1B10 V301L mutant expressed in Escherichia coli BL21(DE3) assessed as NADP+-linked geraniol oxidation [AID697014, Type: Literature]
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19
[SID103350986]
IC50 2.2Antitrypanosomal activity against Trypanosoma brucei brucei bloodstream trypomastigotes by alamar blue assay [AID311138, Type: Literature]
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20
[SID103350986]
IC50 2.3In vitro inhibitory concentration against phospholipase A2 of Echis carinatus venom [AID241486, Type: Literature]Acidic phospholipase A2 EC-I [gi:82096307]
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