ST50738465 (CID 6484377) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(65)
 
 
Inactive(508)
 
 
Inconclusive(18)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
alkPPc(17)
 
 
 
Bcl-2 like(10)
 
 
Peptidase C48(8)
 
 
 
Pyruvate Kina..(8)
 
 
 
BioAssay Types:
Screening(378)
 
 
 
 
Confirmatory(192)
 
 
 
 
 
Literature(7)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(136)
 
 
 
 
 
IC50(34)
 
 
EC50(12)
 
 
 
AC50(5)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 593    Data Row: 593   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24784938]
Potency 0.9268qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox [AID588382, Type: confirmatory]
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2
[SID24784938]
Potency 1.4125qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]RAB9A gene product [Homo sapiens] [gi:4759012]
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3
[SID24784938]
Potency 1.5849qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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4
[SID24784938]
Potency 1.5849Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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5
[SID24784938]
Potency 1.7783qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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6
[SID24784938]
Potency 2.1331qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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7
[SID24784938]
AC50 2.228Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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8
[SID24784938]
Potency 2.3086Confirmation Concentration-Response Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID2263, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
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9
[SID24784938]
Potency 2.3086Confirmation Concentration-Response Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID2263, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
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10
[SID24784938]
Potency 2.3086Confirmation Concentration-Response Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID2263, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
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11
[SID24784938]
AC50 2.482Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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12
[SID24784938]
AC50 2.897ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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13
[SID24784938]
Potency 2.9093qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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14
[SID24784938]
Potency 3.6537qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
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15
[SID24784938]
Potency 4.4668qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Mammalian cellular toxicity [AID2786, Type: confirmatory]
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16
[SID24784938]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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17
[SID24784938]
Potency 5.0119qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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18
[SID24784938]
AC50 6.117HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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19
[SID24784938]
AC50 6.117HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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20
[SID24784938]
AC50 6.117HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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21
[SID24784938]
Potency 6.3096qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
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22
[SID24784938]
Potency 6.3096qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
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23
[SID24784938]
Potency 6.3096qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]PKM gene product [Homo sapiens] [gi:33286418]
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24
[SID24784938]
Potency 6.5064Secondary assay for Inhibitors of Human Pyruvate Kinase M2 isoform: FLuc Counterscreen [AID2265, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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25
[SID24784938]
Potency 6.5064Secondary Assay for Luciferase (Kinase-Glo TM) Inhibition Counterscreen [AID2530, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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26
[SID24784938]
Potency 7.3003Confirmation Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID2559, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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27
[SID24784938]
Potency 7.9433qHTS Assay for Inhibitors of the HIV-1 protein Vpr [AID651644, Type: confirmatory]Vpr [Human immunodeficiency virus 1] [gi:28872817]
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28
[SID24784938]
EC50 11.4Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. [AID488886, Type: confirmatory]alkaline phosphatase, tissue-nonspecific isozyme isoform 1 precursor [Homo sapiens] [gi:116734717]
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29
[SID24784938]
EC50 11.4Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. [AID488886, Type: confirmatory]alkaline phosphatase, tissue-nonspecific isozyme isoform 1 precursor [Homo sapiens] [gi:116734717]
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30
[SID24784938]
EC50 12.3Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay [AID463120, Type: confirmatory]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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31
[SID24784938]
EC50 12.3Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay [AID463120, Type: confirmatory]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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32
[SID24784938]
Potency 14.1254qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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33
[SID24784938]
EC50 15.3Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase [AID488888, Type: confirmatory]alkaline phosphatase, placental-like preproprotein [Homo sapiens] [gi:157266296]
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34
[SID24784938]
EC50 15.3Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase [AID488888, Type: confirmatory]alkaline phosphatase, placental-like preproprotein [Homo sapiens] [gi:157266296]
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35
[SID24784938]
Potency 15.8114qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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36
[SID24784938]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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37
[SID24784938]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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38
[SID24784938]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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39
[SID24784938]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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40
[SID24784938]
Potency 20.5962qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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41
[SID24784938]
Potency 22.3872qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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42
[SID24784938]
EC50 23.2Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay - Set 2 [AID488817, Type: confirmatory]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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43
[SID24784938]
EC50 23.2Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay - Set 2 [AID488817, Type: confirmatory]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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44
[SID24784938]
Potency 39.8107qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Giardia lamblia growth inhibition [AID2785, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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45
[SID24784938]
Potency 56.2341qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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46
[SID24784938]
 Luminescence-based confirmation cell-based assay for cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1907, Type: screening]
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47
[SID24784938]
 Luminescence-based counterscreen assay for KLF5 inhibitors: cell-based high throughput screening assay to identify cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1825, Type: screening]
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48
[SID24784938]
 Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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49
[SID24784938]
 Counter Screen for Luciferase-based Primary Inhibition Assays [AID1006, Type: screening]
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50
[SID24784938]
 Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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