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1,3-dipropyl-8-(3-noradamantyl)xanthine (CID 64627) - Compound BioActivity Data
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BioActivity Outcomes:
Active(25)
 
 
Unspecified(61)
 
 
Top Targets:
7TM GPCR Srsx(20)
 
 
 
MFS(4)
 
 
BioAssay Types:
Literature(81)
 
 
 
BioActivity Types:
Ki(23)
 
 
 
IC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 80    Data Row: 86   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103234175]
Ki 0.000145Binding affinity to mouse adenosine A1 receptor [AID462308, Type: Literature]Adenosine receptor A1 [gi:341940620]
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2
[SID103234175]
Ki 0.00019Binding affinity towards adenosine A1 receptor in rat forebrain membranes using N6-[3H]cyclohexyladenosine [AID32193, Type: Literature]Adenosine receptor A1 [gi:2827766]
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3
[SID103234175]
Ki 0.00019Binding affinity at bovine Adenosine A1 receptor. [AID31984, Type: Literature]
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4
[SID103234175]
Ki 0.000295Binding affinity to human adenosine A1 receptor [AID462302, Type: Literature]Adenosine receptor A1 [gi:231473]
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5
[SID103234175]
Ki 0.00072Inhibition of binding to membranes from HEK293 cells expressing human Adenosine A1 receptor [AID30772, Type: Literature]Adenosine receptor A1 [gi:231473]
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6
[SID103234175]
Ki 0.0011Binding affinity for Adenosine A1 receptor from Guinea pig membranes [AID32168, Type: Literature]Adenosine receptor A1 [gi:1351830]
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7
[SID103234175]
Ki 0.0013Binding affinity towards adenosine A1 receptor using N6-[3H]cyclohexyladenosine in guinea pig forebrain membranes [AID32289, Type: Literature]Adenosine receptor A1 [gi:1351830]
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8
[SID103234175]
Ki 0.0013Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]cyclohexyladenosine as radioligand [AID32292, Type: Literature]Adenosine receptor A1 [gi:1351830]
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9
[SID103234175]
Ki 0.0013Binding affinity against adenosine A1 receptor using N6-[3H]cyclohexyladenosine as radioligand in guinea pig forebrain membranes [AID32163, Type: Literature]Adenosine receptor A1 [gi:1351830]
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10
[SID103234175]
Ki 0.0013Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand [AID32177, Type: Literature]
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11
[SID103234175]
Ki 0.0126Binding affinity for Adenosine A1 receptor of rat forebrain [AID32033, Type: Literature]Adenosine receptor A1 [gi:2827766]
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12
[SID103234175]
Ki 0.108Inhibition of binding to membranes from HEK293 cells expressing human Adenosine A2 receptor [AID30790, Type: Literature]Adenosine receptor A2a [gi:543740]
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13
[SID103234175]
Ki 0.108Inhibition of binding to membranes from HEK293 cells expressing human Adenosine A2 receptor [AID30790, Type: Literature]Adenosine receptor A2b [gi:112938]
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14
[SID103234175]
Ki 0.23Binding affinity for Adenosine A2 receptor from Guinea pig membranes [AID30625, Type: Literature]
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15
[SID103234175]
Ki 0.38Binding affinity against adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide as radioligand in rat striatal membranes. [AID33563, Type: Literature]
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16
[SID103234175]
Ki 0.38Binding affinity against adenosine A2 receptor in rat striatal membranes using N-[3H]-ethyladenosin-5''-uronamide as radioligand in the presence of 50 nM cyclopentyladenosine [AID33587, Type: Literature]
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17
[SID103234175]
Ki 0.43Binding affinity for adenosine A2 receptor using N-[3H]-ethyladenosin-5''-uronamide in guinea pig forebrain membranes [AID30502, Type: Literature]
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18
[SID103234175]
Ki 0.51Binding affinity for Adenosine A2 receptor from rat striatal membranes [AID33576, Type: Literature]Adenosine receptor A2a [gi:8928539]
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19
[SID103234175]
Ki 0.51Binding affinity for Adenosine A2 receptor from rat striatal membranes [AID33576, Type: Literature]Adenosine receptor A2b [gi:112939]
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20
[SID103234175]
IC50 Binding affinity to guinea pig adenosine A2A receptor [AID462309, Type: Literature]Adenosine receptor A2a [gi:1168253]
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21
[SID103234175]
IC50 Binding affinity to rat adenosine A1 receptor [AID462305, Type: Literature]Adenosine receptor A1 [gi:2827766]
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22
[SID103234175]
IC50 Binding affinity to rat adenosine A2A receptor [AID462306, Type: Literature]Adenosine receptor A2a [gi:8928539]
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23
[SID85210038]
Ligands of nucleotide-like (Class A) GPCRs [AID2061, Type: other]
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24
[SID103234175]
IC50 Binding affinity to guinea pig adenosine A1 receptor [AID462310, Type: Literature]
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25
[SID103234175]
Binding affinity against adenosine A2 receptor using [3H]- NECA as radioligand [AID33746, Type: Literature]
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26
[SID103234175]
Ki 3.7TP_TRANSPORTER: inhibition of E1S uptake in OAT3-expressing S2 cells [AID678987, Type: other]Solute carrier family 22 member 8 [gi:74730587]
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27
[SID103234175]
Ki 7.82TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells [AID678999, Type: other]Solute carrier family 22 member 6 [gi:74762955]
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28
[SID103234175]
Ki 20.7TP_TRANSPORTER: inhibition of E1S uptake in OAT4-expressing S2 cells [AID679295, Type: other]Solute carrier family 22 member 11 [gi:74734337]
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29
[SID103234175]
Ki TP_TRANSPORTER: inhibition of PGF2alpha uptake in OAT2-expressing S2 cells [AID678962, Type: other]Solute carrier family 22 member 7 [gi:74753520]
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30
[SID103234175]
Selectivity as ratio of Ki against rat adenosine A2a and A1 receptor binding [AID232495, Type: Literature]Adenosine receptor A2a [gi:8928539]
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31
[SID103234175]
Solubility was measured in saline [AID21763, Type: Literature]
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32
[SID103234175]
Solubility of the compound(10 mg) was measured in water(2.5 mL) at 20 degree celsius for 1 hr [AID21767, Type: Literature]
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33
[SID103234175]
Oral diuretic activity was measured after oral administration of 6.25 mg/kg to rats(control volume is 0.80+/-0.02) [AID191352, Type: Literature]
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34
[SID103234175]
Percent inhibition of serum creatinine by the compound given as ratio of Cr value in treated to vehicle treated ones after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 2.75+/-0.43) [AID192683, Type: Literature]
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35
[SID103234175]
Percent inhibition of Urea nitrogen by the compound given as ratio of UN value in treated to vehicle treated ones after intraperitoneal administration of 1 mg/kg of compound to rats(vehicle 123.2+/-14.2) [AID194944, Type: Literature]
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36
[SID103234175]
Ratio of Ki at A2 receptor to that of A1 receptor [AID228357, Type: Literature]
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37
[SID103234175]
Selectivity as ratio of Ki against adenosine A2a and A1 receptor binding in guinea pig [AID232493, Type: Literature]
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38
[SID103234175]
Selectivity as ratio of Ki against rat adenosine A2a and A1 receptor binding [AID232495, Type: Literature]Adenosine receptor A1 [gi:2827766]
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39
[SID103234175]
Selectivity as ratio of Ki against rat adenosine A2a and A1 receptor binding [AID232495, Type: Literature]Adenosine receptor A2b [gi:112939]
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40
[SID103234175]
Selectivity as ratio of Ki against human adenosine A2a and A1 receptor binding [AID232494, Type: Literature]Adenosine receptor A2b [gi:112938]
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41
[SID103234175]
Selectivity as ratio of Ki against human adenosine A2a and A1 receptor binding [AID232494, Type: Literature]Adenosine receptor A2a [gi:543740]
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42
[SID103234175]
Selectivity as ratio of Ki against human adenosine A2a and A1 receptor binding [AID232494, Type: Literature]Adenosine receptor A1 [gi:231473]
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43
[SID103234175]
Oral diuretic activity was measured after oral administration of 0.005 mg/kg to rats(control volume is 0.76+/-0.01) [AID191032, Type: Literature]
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44
[SID103234175]
Oral diuretic activity was measured after oral administration of 0.025 mg/kg to rats(control volume is 0.82+/-0.05) [AID191035, Type: Literature]
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45
[SID103234175]
Oral diuretic activity was measured after oral administration of 0.1 mg/kg to rats(control volume is 0.92+/-0.05) [AID191037, Type: Literature]
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46
[SID103234175]
Oral diuretic activity was measured after oral administration of 0.4 mg/kg to rats(control volume is 1.4+/-0.05) [AID191177, Type: Literature]
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47
[SID103234175]
Oral diuretic activity was measured after oral administration of 1.6 mg/kg to rats(control volume is 1.06+/-0.02) [AID191191, Type: Literature]
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48
[SID103234175]
Oral diuretic activity was measured after oral administration of 25 mg/kg to rats(control volume is 0.66+/-0.04) [AID191197, Type: Literature]
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49
[SID103234175]
Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 0.4 mg/Kg [AID189933, Type: Literature]
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50
[SID103234175]
Ratio of urinary excretion value (urinary volume) in treated rats to that in control rats, at a peroral dose of 1.6 mg/Kg [AID189935, Type: Literature]
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