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axitinib (CID 6450551) - Compound BioActivity Data
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BioActivity Outcomes:
Active(527)
 
 
Inactive(54)
 
 
Inconclusive(34)
 
 
Unspecified(535)
 
 
Top Targets:
PTKc Abl(16)
 
 
PTKc EGFR(12)
 
 
 
PI3Kc IA alph..(10)
 
 
PKc like(9)
 
 
 
PTKc Kit(8)
 
 
BioAssay Types:
Confirmatory(662)
 
 
 
 
 
Literature(458)
 
 
 
Summary(24)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
IC50(582)
 
 
 
Kd(442)
 
 
 
Potency(105)
 
 
 
 
Ki(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1145    Data Row: 1150   Total Pages: 58   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID170484658]
Ki 2e-05Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of Vegfr2 (Juxtamembrane And Kinase Domains) In Complex With Axitinib (Ag-013736) (N-Methyl-2-( 3-((E)-2-Pyridin-2-Yl-Vinyl)-1h-Indazol-6-Ylsulfanyl)- Benzamide) [gi:406855590]
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2
[SID170484658]
Ki 2e-05Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of Vegfr2 (Juxtamembrane And Kinase Domains) In Complex With Axitinib (Ag-013736) (N-Methyl-2-( 3-((E)-2-Pyridin-2-Yl-Vinyl)-1h-Indazol-6-Ylsulfanyl)- Benzamide) [gi:406855590]
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3
[SID123098392]
IC50 5.13e-05SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay. [AID742166, Type: confirmatory]
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4
[SID123098392]
IC50 0.00025Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assay [AID538338, Type: Literature]
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5
[SID123098392]
Kd 0.00049Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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6
[SID123098392]
Kd 0.00051Binding constant for PDGFRA kinase domain [AID625034, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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7
[SID123098392]
Kd 0.00057Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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8
[SID123098392]
IC50 0.000902SANGER: Inhibition of human NCI-H1703 cell growth in a cell viability assay. [AID741708, Type: confirmatory]
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9
[SID170484657]
Ki 0.0011Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of The Vegfr2 Kinase Domain In Complex With Axitinib (Ag-013736) (N-Methyl-2-(3-((E)-2-Pyridin-2- Yl-Vinyl)-1h-Indazol-6-Ylsulfanyl)-Benzamide) [gi:406855589]
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10
[SID170484657]
Ki 0.0011Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of The Vegfr2 Kinase Domain In Complex With Axitinib (Ag-013736) (N-Methyl-2-(3-((E)-2-Pyridin-2- Yl-Vinyl)-1h-Indazol-6-Ylsulfanyl)-Benzamide) [gi:406855589]
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11
[SID123098392]
Kd 0.0013Binding constant for AURKC kinase domain [AID624769, Type: Literature]Aurora kinase C [gi:27805738]
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12
[SID123098392]
Kd 0.0014Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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13
[SID123098392]
Kd 0.0015Binding constant for ABL1(T315I)-phosphorylated kinase domain [AID624989, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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14
[SID123098392]
Kd 0.0017Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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15
[SID123098392]
Kd 0.0032Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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16
[SID123098392]
Kd 0.0035Binding constant for KIT(V559D,V654A) kinase domain [AID624793, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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17
[SID123098392]
Kd 0.0036Binding constant for ABL1(T315I)-non phosphorylated kinase domain [AID624988, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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18
[SID123098392]
Ki 0.0042Inhibition of human PLK4 [AID762206, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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19
[SID123098392]
Kd 0.0058Binding constant for FLT1 kinase domain [AID624853, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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20
[SID123098392]
Kd 0.0059Binding constant for VEGFR2 kinase domain [AID624860, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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