axitinib (CID 6450551) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(138)
 
 
Inactive(14)
 
 
Unspecified(308)
 
 
Top Targets:
PKc(55)
 
 
 
PKc like(34)
 
 
 
STKc AGC(24)
 
 
 
PTKc Abl(16)
 
 
PTKc EGFR(12)
 
 
 
BioAssay Types:
Literature(443)
 
 
 
Confirmatory(15)
 
 
 
Screening(2)
 
 
BioActivity Types:
Kd(442)
 
 
 
Potency(15)
 
 
 
IC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 460    Data Row: 460   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID123098392]
IC50 0.00025Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assay [AID538338, Type: Literature]
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2
[SID123098392]
Kd 0.00049Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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3
[SID123098392]
Kd 0.00049Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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4
[SID123098392]
Kd 0.00051Binding constant for PDGFRA kinase domain [AID625034, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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5
[SID123098392]
Kd 0.00051Binding constant for PDGFRA kinase domain [AID625034, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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6
[SID123098392]
Kd 0.00057Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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7
[SID123098392]
Kd 0.00057Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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8
[SID123098392]
Kd 0.0013Binding constant for AURKC kinase domain [AID624769, Type: Literature]Aurora kinase C [gi:27805738]
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9
[SID123098392]
Kd 0.0013Binding constant for AURKC kinase domain [AID624769, Type: Literature]Aurora kinase C [gi:27805738]
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10
[SID123098392]
Kd 0.0014Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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11
[SID123098392]
Kd 0.0014Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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12
[SID123098392]
Kd 0.0015Binding constant for ABL1(T315I)-phosphorylated kinase domain [AID624989, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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13
[SID123098392]
Kd 0.0015Binding constant for ABL1(T315I)-phosphorylated kinase domain [AID624989, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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14
[SID123098392]
Kd 0.0017Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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15
[SID123098392]
Kd 0.0017Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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16
[SID123098392]
Kd 0.0032Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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17
[SID123098392]
Kd 0.0032Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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18
[SID123098392]
Kd 0.0035Binding constant for KIT(V559D,V654A) kinase domain [AID624793, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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19
[SID123098392]
Kd 0.0035Binding constant for KIT(V559D,V654A) kinase domain [AID624793, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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20
[SID123098392]
Kd 0.0036Binding constant for ABL1(T315I)-nonphosphorylated kinase domain [AID624988, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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21
[SID123098392]
Kd 0.0036Binding constant for ABL1(T315I)-nonphosphorylated kinase domain [AID624988, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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22
[SID123098392]
Kd 0.0058Binding constant for FLT1 kinase domain [AID624853, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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23
[SID123098392]
Kd 0.0058Binding constant for FLT1 kinase domain [AID624853, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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24
[SID123098392]
Kd 0.0059Binding constant for VEGFR2 kinase domain [AID624860, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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25
[SID123098392]
Kd 0.0059Binding constant for VEGFR2 kinase domain [AID624860, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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26
[SID123098392]
Kd 0.011Binding constant for AURKB kinase domain [AID624772, Type: Literature]Aurora kinase B [gi:317373473]
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27
[SID123098392]
Kd 0.011Binding constant for AURKB kinase domain [AID624772, Type: Literature]Aurora kinase B [gi:317373473]
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28
[SID123098392]
Kd 0.011Binding constant for AURKB kinase domain [AID624772, Type: Literature]Aurora kinase B [gi:317373473]
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29
[SID123098392]
Kd 0.016Binding constant for PLK4 kinase domain [AID625076, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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30
[SID123098392]
Kd 0.016Binding constant for PLK4 kinase domain [AID625076, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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31
[SID123098392]
Kd 0.02Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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32
[SID123098392]
Kd 0.02Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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33
[SID123098392]
Kd 0.021Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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34
[SID123098392]
Kd 0.021Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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35
[SID123098392]
Kd 0.023Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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36
[SID123098392]
Kd 0.023Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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37
[SID123098392]
Kd 0.031Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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38
[SID123098392]
Kd 0.031Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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39
[SID123098392]
Kd 0.031Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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40
[SID123098392]
Kd 0.036Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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41
[SID123098392]
Kd 0.036Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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42
[SID123098392]
Kd 0.036Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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43
[SID123098392]
Kd 0.036Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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44
[SID123098392]
Kd 0.042Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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45
[SID123098392]
Kd 0.042Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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46
[SID123098392]
Kd 0.042Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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47
[SID123098392]
Kd 0.063Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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48
[SID123098392]
Kd 0.063Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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49
[SID123098392]
Kd 0.07Binding constant for ABL2 kinase domain [AID624993, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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50
[SID123098392]
Kd 0.07Binding constant for ABL2 kinase domain [AID624993, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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