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axitinib (CID 6450551) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(516)
 
 
Inactive(46)
 
 
Inconclusive(38)
 
 
Unspecified(532)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
STKc AGC(17)
 
 
 
PTKc Abl(16)
 
 
PTKc EGFR(12)
 
 
 
BioAssay Types:
Literature(444)
 
 
 
Confirmatory(82)
 
 
 
 
Summary(24)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
IC50(578)
 
 
 
Kd(442)
 
 
 
Potency(101)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1130    Data Row: 1132   Total Pages: 23   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID123098392]
IC50 5.13e-05SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay. [AID742166, Type: other]
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2
[SID123098392]
IC50 0.00025Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assay [AID538338, Type: Literature]
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3
[SID123098392]
Kd 0.00049Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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4
[SID123098392]
Kd 0.00051Binding constant for PDGFRA kinase domain [AID625034, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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5
[SID123098392]
Kd 0.00057Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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6
[SID123098392]
IC50 0.000902SANGER: Inhibition of human NCI-H1703 cell growth in a cell viability assay. [AID741708, Type: other]
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7
[SID123098392]
Kd 0.0013Binding constant for AURKC kinase domain [AID624769, Type: Literature]Aurora kinase C [gi:27805738]
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8
[SID123098392]
Kd 0.0014Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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9
[SID123098392]
Kd 0.0015Binding constant for ABL1(T315I)-phosphorylated kinase domain [AID624989, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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10
[SID123098392]
Kd 0.0017Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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11
[SID123098392]
Kd 0.0032Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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12
[SID123098392]
Kd 0.0035Binding constant for KIT(V559D,V654A) kinase domain [AID624793, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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13
[SID123098392]
Kd 0.0036Binding constant for ABL1(T315I)-nonphosphorylated kinase domain [AID624988, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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14
[SID123098392]
Kd 0.0058Binding constant for FLT1 kinase domain [AID624853, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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15
[SID123098392]
Kd 0.0059Binding constant for VEGFR2 kinase domain [AID624860, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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16
[SID123098392]
IC50 0.00682SANGER: Inhibition of human KASUMI-1 cell growth in a cell viability assay. [AID742267, Type: other]
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17
[SID123098392]
IC50 0.00722SANGER: Inhibition of human CGTH-W-1 cell growth in a cell viability assay. [AID742061, Type: other]
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18
[SID123098392]
IC50 0.00992SANGER: Inhibition of human A204 cell growth in a cell viability assay. [AID741943, Type: other]
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19
[SID123098392]
Kd 0.011Binding constant for AURKB kinase domain [AID624772, Type: Literature]Aurora kinase B [gi:317373473]
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20
[SID123098392]
Kd 0.016Binding constant for PLK4 kinase domain [AID625076, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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21
[SID123098392]
Kd 0.02Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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22
[SID123098392]
Kd 0.021Binding constant for CSF1R kinase domain [AID624995, Type: Literature]Macrophage colony-stimulating factor 1 receptor [gi:547770]
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23
[SID123098392]
Kd 0.023Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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24
[SID123098392]
Kd 0.031Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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25
[SID123098392]
Kd 0.036Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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26
[SID123098392]
Kd 0.036Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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27
[SID123098392]
Kd 0.042Binding constant for FLT3 kinase domain [AID624934, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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28
[SID123098392]
Kd 0.063Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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29
[SID123098392]
Kd 0.07Binding constant for ABL2 kinase domain [AID624993, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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30
[SID123098392]
Kd 0.072Binding constant for AURKA kinase domain [AID624919, Type: Literature]Aurora kinase A [gi:27923855]
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31
[SID123098392]
Kd 0.084Binding constant for ABL1-nonphosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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32
[SID144207146]
Potency-Replicate_1 0.0841qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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33
[SID123098392]
Kd 0.097Binding constant for TIE1 kinase domain [AID625017, Type: Literature]Tyrosine-protein kinase receptor Tie-1 [gi:549081]
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34
[SID123098392]
Kd 0.1Binding constant for RET(M918T) kinase domain [AID625122, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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35
[SID123098392]
IC50 0.10836SANGER: Inhibition of human HOP-62 cell growth in a cell viability assay. [AID742219, Type: other]
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36
[SID123098392]
Kd 0.11Binding constant for FGFR2 kinase domain [AID625131, Type: Literature]Fibroblast growth factor receptor 2 [gi:120049]
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37
[SID123098392]
IC50 0.11005SANGER: Inhibition of human H-EMC-SS cell growth in a cell viability assay. [AID742185, Type: other]
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38
[SID123098392]
Kd 0.12Binding constant for RET kinase domain [AID625121, Type: Literature]Proto-oncogene tyrosine-protein kinase receptor Ret [gi:547807]
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39
[SID123098392]
Kd 0.14Binding constant for MEK5 kinase domain [AID624721, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 5 [gi:118572669]
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40
[SID123098392]
Kd 0.16Binding constant for TNK1 kinase domain [AID624930, Type: Literature]Non-receptor tyrosine-protein kinase TNK1 [gi:116242821]
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41
[SID123098392]
IC50 0.16577SANGER: Inhibition of human KU812 cell growth in a cell viability assay. [AID742287, Type: other]
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42
[SID123098392]
IC50 0.16816SANGER: Inhibition of human EM-2 cell growth in a cell viability assay. [AID742144, Type: other]
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43
[SID123098392]
Kd 0.17Binding constant for FLT4 kinase domain [AID624854, Type: Literature]Vascular endothelial growth factor receptor 3 [gi:357529070]
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44
[SID123098392]
IC50 0.17665SANGER: Inhibition of human LAMA-84 cell growth in a cell viability assay. [AID742302, Type: other]
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45
[SID123098392]
Kd 0.18Binding constant for TNIK kinase domain [AID625093, Type: Literature]TRAF2 and NCK-interacting protein kinase [gi:29840818]
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46
[SID123098392]
Kd 0.2Binding constant for FLT3(N841I) kinase domain [AID624939, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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47
[SID123098392]
Kd 0.2Binding constant for ABL1(Q252H)-phosphorylated kinase domain [AID624987, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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48
[SID123098392]
Kd 0.21Binding constant for FGFR3 kinase domain [AID624782, Type: Literature]Fibroblast growth factor receptor 3 [gi:120050]
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49
[SID123098392]
Kd 0.21Binding constant for FGFR3(G697C) kinase domain [AID624783, Type: Literature]Fibroblast growth factor receptor 3 [gi:120050]
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50
[SID123098392]
Kd 0.23Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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