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EKB 569 (CID 6445562) - Compound BioActivity Data
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BioActivity Outcomes:
Active(204)
 
 
Inactive(153)
 
 
Unspecified(228)
 
 
Top Targets:
PKc(52)
 
 
 
 
PKc like(49)
 
 
 
 
PTKc EGFR(31)
 
 
 
STKc AGC(29)
 
 
 
 
PTKc Abl(23)
 
 
 
BioAssay Types:
Literature(476)
 
 
 
 
Confirmatory(108)
 
 
 
BioActivity Types:
Kd(437)
 
 
 
 
IC50(23)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 477    Data Row: 585   Total Pages: 30   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103730344]
Kd 0.00023Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID435906, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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2
[SID103730344]
IC50 0.00024Inhibition of EGFR [AID510254, Type: Literature]
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3
[SID103730344]
Kd 0.00024Binding constant for EGFR(G719C) kinase domain [AID435157, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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4
[SID103730344]
Kd 0.00024Binding constant for EGFR(L747-E749del, A750P) kinase domain [AID435652, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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5
[SID103730344]
Kd 0.00027Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID435653, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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6
[SID103730344]
Kd 0.00033Binding constant for EGFR(S752-I759del) kinase domain [AID435792, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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7
[SID103730344]
Kd 0.00038Binding constant for EGFR(E746-A750del) kinase domain [AID435791, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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8
[SID103730344]
Kd 0.00041Binding constant for EGFR(L858R) kinase domain [AID435525, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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9
[SID103730344]
Kd 0.00042Binding constant for EGFR(G719S) kinase domain [AID435402, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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10
[SID103730344]
Kd 0.00044Binding constant for EGFR kinase domain [AID435156, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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11
[SID103730344]
Kd 0.00044Binding constant for EGFR(L861Q) kinase domain [AID435907, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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12
[SID103730344]
IC50 0.0006Inhibition of human EGFR in presence of 1 uM ATP [AID295762, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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13
[SID103730344]
Kd 0.001Average Binding Constant for EGFR; NA=Not Active at 10 uM [AID256664, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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14
[SID103730344]
Kd 0.0015Average Binding Constant for GAK; NA=Not Active at 10 uM [AID256612, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
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15
[SID103730344]
Kd 0.0037Average Binding Constant for MAP4K5; NA=Not Active at 10 uM [AID256565, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 5 [gi:30316147]
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16
[SID103730344]
Kd 0.0064Binding constant for GAK kinase domain [AID435821, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
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17
[SID103730344]
IC50 0.00802Inhibition of EGFR autophosphorylation in human A431 cells [AID510404, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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18
[SID103730344]
IC50 0.01Concentration required to inhibit growth of human carcinoma breast (SKBR3) cell line [AID202682, Type: Literature]
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19
[SID103730344]
IC50 0.01Inhibition of human A431 cell proliferation [AID247761, Type: Literature]
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20
[SID103730344]
Kd 0.01Binding constant for MAP4K5 kinase domain [AID435805, Type: Literature]Mitogen-activated protein kinase kinase kinase kinase 5 [gi:30316147]
View