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4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide (CID 644241) - Compound BioActivity Data
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BioActivity Outcomes:
Active(389)
 
 
Inactive(55)
 
 
Inconclusive(5)
 
 
Unspecified(743)
 
 
Top Targets:
PKc(48)
 
 
PKc like(40)
 
 
 
PTKc Abl(20)
 
 
 
STKc AGC(17)
 
 
PTKc Kit(12)
 
 
 
BioAssay Types:
Literature(561)
 
 
 
 
 
Screening(26)
 
 
Confirmatory(25)
 
 
 
 
BioActivity Types:
IC50(679)
 
 
 
 
Kd(448)
 
 
 
Potency(26)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1188    Data Row: 1192   Total Pages: 24   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103563888]
IC50 0.000144SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay. [AID742166, Type: other]
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2
[SID103563888]
Kd 0.0011Binding constant for DDR1 kinase domain [AID624850, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
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3
[SID103563888]
IC50 0.00154Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl M244V mutant after 72 hrs by CCK-8 assay [AID709992, Type: Literature]
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4
[SID103563888]
IC50 0.00248SANGER: Inhibition of human KU812 cell growth in a cell viability assay. [AID742287, Type: other]
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5
[SID103563888]
IC50 0.00254Inhibition of human PDGFRalpha using poly[Glu:Tyr] (4:1) peptide substrate [AID722270, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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6
[SID103563888]
IC50 0.00254Inhibition of human ABL1 using EAIYAAPFAKKK peptide substrate [AID722273, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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7
[SID103563888]
IC50 0.00254Inhibition of human DDR2 using KKSRGDYMTMQIG peptide substrate [AID722275, Type: Literature]Discoidin domain-containing receptor 2 [gi:215273969]
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8
[SID103563888]
IC50 0.003Cytotoxicity against mouse BA/F3 cells expressing BCR-ABL M351T mutant assessed as growth inhibition after 72 hrs by CCK-8 assay [AID724668, Type: Literature]
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9
[SID103563888]
IC50 0.0034Antiproliferative activity against human KU812 cells [AID590030, Type: Literature]
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10
[SID103563888]
Kd 0.0036Binding affinity to human ABL1 [AID722268, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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11
[SID103563888]
IC50 0.0037Inhibition of autophosphorylation of DDR1 expressed in HEK293 cells by ELISA [AID515827, Type: Literature]
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12
[SID103563888]
IC50 0.0041SANGER: Inhibition of human EM-2 cell growth in a cell viability assay. [AID742144, Type: other]
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13
[SID103563888]
IC50 0.0049SANGER: Inhibition of human LAMA-84 cell growth in a cell viability assay. [AID742302, Type: other]
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14
[SID103563888]
Kd 0.0049Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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15
[SID103563888]
IC50 0.0052Inhibition of autophosphorylation of DDR2 expressed in HEK293 cells by ELISA [AID515826, Type: Literature]
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16
[SID103563888]
Kd 0.0062Binding affinity to human DDR2 [AID722265, Type: Literature]Discoidin domain-containing receptor 2 [gi:215273969]
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17
[SID103563888]
IC50 0.00634Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl H396P mutant after 72 hrs by CCK-8 assay [AID709991, Type: Literature]
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18
[SID103563888]
IC50 0.0065Antiproliferative activity against human K562 cells [AID590029, Type: Literature]
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19
[SID103563888]
IC50 0.00828SANGER: Inhibition of human MEG-01 cell growth in a cell viability assay. [AID742350, Type: other]
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20
[SID103563888]
IC50 0.00838Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl E355G mutant after 72 hrs by CCK-8 assay [AID709993, Type: Literature]
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21
[SID103563888]
IC50 0.0095Cytotoxicity against mouse BA/F3 cells expressing BCR-ABL F486S mutant assessed as growth inhibition after 72 hrs by CCK-8 assay [AID724664, Type: Literature]
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22
[SID103563888]
IC50 0.01Inhibition of human c-Kit V650G mutant using poly[Glu:Tyr] (4:1) peptide substrate [AID722257, Type: Literature]
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23
[SID103563888]
Kd 0.01Binding constant for ABL1(Q252H)-nonphosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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24
[SID103563888]
Kd 0.01Binding constant for ABL1-nonphosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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25
[SID103563888]
IC50 0.0103Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl M351T mutant after 72 hrs by CCK-8 assay [AID709997, Type: Literature]
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26
[SID103563888]
IC50 0.01089SANGER: Inhibition of human BV-173 cell growth in a cell viability assay. [AID741988, Type: other]
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27
[SID103563888]
Kd 0.011Binding constant for ZAK kinase domain [AID624755, Type: Literature]Mitogen-activated protein kinase kinase kinase MLT [gi:313104215]
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28
[SID103563888]
Kd 0.012Binding constant for ABL1(F317L)-nonphosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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29
[SID103563888]
IC50 0.0128Inhibition of human recombinant ABL1 M351T mutant expressed in insect cells after 30 mins by FRET assay [AID724975, Type: Literature]
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30
[SID103563888]
Kd 0.013Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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31
[SID103563888]
Kd 0.013Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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32
[SID103563888]
Kd 0.014Binding constant for ABL1(F317L)-phosphorylated kinase domain [AID624982, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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33
[SID103563888]
IC50 0.0147Inhibition of human c-Kit using poly[Glu:Tyr] (4:1) peptide substrate [AID722274, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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34
[SID103563888]
IC50 0.015Antiproliferative activity against human K562 cells after 72 hrs by CCK8 assay [AID732825, Type: Literature]
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35
[SID103563888]
Kd 0.015Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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36
[SID103563888]
IC50 0.0158Inhibition of human recombinant ABL1 H396P mutant expressed in insect cells after 30 mins by FRET assay [AID724976, Type: Literature]
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37
[SID103563888]
Kd 0.016Binding affinity to human PDGFRbeata [AID722262, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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38
[SID103563888]
Kd 0.017Binding affinity to human c-Kit [AID722264, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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39
[SID103563888]
Kd 0.018Binding constant for ABL1(F317I)-nonphosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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40
[SID103563888]
IC50 0.02Inhibition of autophosphorylation of BCR-ABL1 expressed in Ba/F cells [AID515831, Type: Literature]
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41
[SID103563888]
IC50 0.021Antiproliferative activity against human K562 cells [AID515834, Type: Literature]
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42
[SID103563888]
IC50 0.021Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl F486S mutant after 72 hrs by CCK-8 assay [AID709996, Type: Literature]
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43
[SID103563888]
Kd 0.021Binding constant for ABL1(Q252H)-phosphorylated kinase domain [AID624987, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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44
[SID103563888]
Kd 0.021Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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45
[SID103563888]
IC50 0.022Cytotoxicity against mouse BA/F3 cells expressing wild type BCR-ABL assessed as growth inhibition after 72 hrs by CCK-8 assay [AID724985, Type: Literature]
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46
[SID103563888]
Kd 0.022Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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47
[SID103563888]
IC50 0.02413SANGER: Inhibition of human KASUMI-1 cell growth in a cell viability assay. [AID742267, Type: other]
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48
[SID103563888]
IC50 0.0242Inhibition of human recombinant ABL1 Q252H mutant expressed in insect cells after 30 mins by FRET assay [AID724978, Type: Literature]
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49
[SID103563888]
IC50 0.025Antiproliferative activity against BCR-ABL1 transfected mouse BA/F3 cells [AID515835, Type: Literature]
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50
[SID103563888]
IC50 0.025Inhibition of PDGFR [AID463623, Type: Literature]
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