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4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide (CID 644241) - Compound BioActivity Data
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BioActivity Outcomes:
Active(393)
 
 
Inactive(60)
 
 
Inconclusive(6)
 
 
Unspecified(745)
 
 
Top Targets:
PTKc Abl(21)
 
 
 
PTKc EGFR(12)
 
 
PTKc Kit(12)
 
 
 
PI3Kc IA alph..(10)
 
 
PKc like(9)
 
 
 
BioAssay Types:
Confirmatory(605)
 
 
 
 
 
Literature(567)
 
 
 
 
 
Screening(28)
 
 
BioActivity Types:
IC50(682)
 
 
 
 
Kd(450)
 
 
 
Potency(30)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1198    Data Row: 1204   Total Pages: 61   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103563888]
IC50 0.000144SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay. [AID742166, Type: confirmatory]
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2
[SID103563888]
IC50 0.00033Inhibition of Bcr-Abl kinase (unknown origin) after 30 mins by HTRF assay [AID744878, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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3
[SID103563888]
IC50 0.00033Inhibition of Bcr-Abl kinase (unknown origin) after 30 mins by HTRF assay [AID744878, Type: Literature]Breakpoint cluster region protein [gi:143811366]
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4
[SID103563888]
Kd 0.0011Binding constant for DDR1 kinase domain [AID624850, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
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5
[SID103563888]
IC50 0.00154Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl M244V mutant after 72 hrs by CCK-8 assay [AID709992, Type: Literature]
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6
[SID103563888]
IC50 0.00248SANGER: Inhibition of human KU812 cell growth in a cell viability assay. [AID742287, Type: confirmatory]
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7
[SID103563888]
IC50 0.00254Inhibition of human PDGFRalpha using poly[Glu:Tyr] (4:1) peptide substrate [AID722270, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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8
[SID103563888]
IC50 0.00254Inhibition of human DDR2 using KKSRGDYMTMQIG peptide substrate [AID722275, Type: Literature]Discoidin domain-containing receptor 2 [gi:215273969]
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9
[SID103563888]
IC50 0.00254Inhibition of human ABL1 using EAIYAAPFAKKK peptide substrate [AID722273, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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10
[SID103563888]
IC50 0.003Cytotoxicity against mouse BA/F3 cells expressing BCR-ABL M351T mutant assessed as growth inhibition after 72 hrs by CCK-8 assay [AID724668, Type: Literature]
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11
[SID103563888]
IC50 0.0034Antiproliferative activity against human KU812 cells [AID590030, Type: Literature]
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12
[SID103563888]
Kd 0.0036Binding affinity to human ABL1 [AID722268, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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13
[SID103563888]
IC50 0.0037Inhibition of autophosphorylation of DDR1 expressed in HEK293 cells by ELISA [AID515827, Type: Literature]
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14
[SID103563888]
IC50 0.0041SANGER: Inhibition of human EM-2 cell growth in a cell viability assay. [AID742144, Type: confirmatory]
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15
[SID103563888]
Kd 0.0049Binding constant for ABL1(H396P)-non phosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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16
[SID103563888]
IC50 0.0049SANGER: Inhibition of human LAMA-84 cell growth in a cell viability assay. [AID742302, Type: confirmatory]
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17
[SID103563888]
IC50 0.0052Inhibition of autophosphorylation of DDR2 expressed in HEK293 cells by ELISA [AID515826, Type: Literature]
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18
[SID103563888]
Kd 0.0062Binding affinity to human DDR2 [AID722265, Type: Literature]Discoidin domain-containing receptor 2 [gi:215273969]
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19
[SID103563888]
IC50 0.00634Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl H396P mutant after 72 hrs by CCK-8 assay [AID709991, Type: Literature]
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20
[SID103563888]
IC50 0.0065Antiproliferative activity against human K562 cells [AID590029, Type: Literature]
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