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Cannabidiol (CID 644019) - Compound BioActivity Data
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BioActivity Outcomes:
Active(8)
 
 
Inconclusive(1)
 
 
Unspecified(28)
 
 
Top Targets:
7TM GPCR Srsx(2)
 
 
 
Amidase(1)
 
 
ANK(1)
 
 
p450(1)
 
 
BioAssay Types:
Literature(37)
 
 
 
 
BioActivity Types:
Ki(3)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 37    Data Row: 37   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103460177]
EC50 0.096Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx [AID482146, Type: Literature]Transient receptor potential cation channel subfamily A member 1 [gi:56749669]
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2
[SID103460177]
EC50 0.445Binding affinity to GPR55 [AID482752, Type: Literature]
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3
[SID103460177]
Ki 2.4Displacement of [3H]CP-55940 from human cannabinoid CB1 receptor expressed in CHO cells [AID482748, Type: Literature]Cannabinoid receptor 1 [gi:115562]
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4
[SID103460177]
Ki 10Displacement of [3H]CP-55940 from human cannabinoid CB2 receptor expressed in CHO cells [AID482749, Type: Literature]Cannabinoid receptor 2 [gi:461697]
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5
[SID103460177]
Ability to suppress the production of reactive oxygen intermediates by activated RAW 264.7 macrophages from BALB/c mice at 8 ug/ml [AID260281, Type: Literature]
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6
[SID103460177]
Ability to suppress nitric acid production by LPS-activated peritoneal macrophages form C57BL/6 mice at 4 ug/ml [AID260282, Type: Literature]
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7
[SID103460177]
Ability to suppress nitric acid production by LPS-activated peritoneal macrophages form C57BL/6 mice at 8 ug/ml [AID260283, Type: Literature]
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8
[SID103460177]
Ability to suppress TNFalpha production by LPS-activated peritoneal macrophages form C57BL/6 mice at 8 ug/ml [AID260286, Type: Literature]
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9
[SID103460177]
Ki 10Displacement of [3H]HU243 from CB1 receptor in Sabra rat brain [AID260287, Type: Literature]Cannabinoid receptor 1 [gi:115563]
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10
[SID103460177]
Mechanism based inhibition of mouse cytochrome P450 CYP3A11 [AID624672, Type: Literature]Cytochrome P450 3A11 [gi:5921911]
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11
[SID103460177]
Inhibitory potency against fatty acid amide hydrolase activity in mouse brain microsomes in presence of 58 uM anandamide at 160 uM [AID243998, Type: Literature]Fatty-acid amide hydrolase 1 [gi:6225311]
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12
[SID103460177]
Antiosteoporotic activity in mouse assessed as decrease in bone resorption-associated serum CTX-1 level at 10 mg/kg administered 3 times a week for 8 weeks [AID482753, Type: Literature]
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13
[SID103460177]
Antiosteoporotic activity in mouse assessed as increase in bone volume at 10 mg/kg administered 3 times a week for 8 weeks [AID482754, Type: Literature]
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14
[SID103460177]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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15
[SID103460177]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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16
[SID103460177]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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17
[SID103460177]
Capability to induce convulsions in tetrahydrocannabinol-seizure susceptible (THC-SS) rabbit [AID165405, Type: Literature]
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18
[SID103460177]
Number of rabbits convulsed at 15 mg/kg, iv out of 7 rabbits tested [AID167511, Type: Literature]
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19
[SID103460177]
Number of rabbits convulsed at 20 mg/kg, iv out of 6 rabbits tested [AID167517, Type: Literature]
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20
[SID103460177]
Virtual screen for compounds with anticonvulsant activity [AID227699, Type: Literature]
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