CHEMBL58106 (CID 6440160) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(4)
 
 
Unspecified(2)
 
 
Top Targets:
Lipocalin(5)
 
 
 
BioAssay Types:
Literature(6)
 
 
 
BioActivity Types:
EC50(1)
 
 
SAR
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 6    Data Row: 6   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103248666]
EC50 0.245Antagonist activity at His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as disruption of ROH-sRBP-TTR protein interaction after 2 hr by TR-FRET assay [AID606066, Type: Literature]Retinol-binding protein 4 [gi:62298174]
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2
[SID103248666]
 Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as disruption of sRBP-TTR protein interaction after 1 hr by SDS-PAGE and silver staining method [AID606064, Type: Literature]Retinol-binding protein 4 [gi:62298174]
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3
[SID103248666]
 Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as apparent dissociation constant after 5 mins by fluorescence spectrophotometric analysis [AID606062, Type: Literature]Retinol-binding protein 4 [gi:62298174]
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4
[SID103248666]
 Binding affinity to immobilized His-tagged recombinant human sRBP assessed as inhibition of sRBP and detergent treated HEK293 membrane interaction at 100 uM after 1 hr by surface plasmon resonance assay [AID606163, Type: Literature]Retinol-binding protein 4 [gi:62298174]
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5
[SID103248666]
ED50 0.001Reversal of keratinization in vitamin A deficient hamster trachea culture [AID84861, Type: Literature]
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6
[SID103248666]
 Antagonist activity at His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as disruption of ROH-sRBP-TTR protein interaction after 2 hr by TR-FRET assay relative to control [AID606161, Type: Literature]Retinol-binding protein 4 [gi:62298174]
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