N-(3-phenoxycinnamyl)acetohydroxamic acid (CID 6438354) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(25)
 
 
Inactive(24)
 
 
Inconclusive(2)
 
 
Unspecified(20)
 
 
Top Targets:
Lipoxygenase(27)
 
 
 
MAPEG(5)
 
 
 
 
 
prostaglandin..(2)
 
 
RIP(2)
 
 
NR LBD TR(2)
 
 
BioAssay Types:
Literature(47)
 
 
 
 
 
Confirmatory(21)
 
 
 
Screening(3)
 
 
BioActivity Types:
IC50(29)
 
 
 
 
Potency(21)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 71    Data Row: 71   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103289206]
IC50 0.038Inhibition of recombinant human 5-Lipoxygenase expressed in Escherichia coli lysate after 10 mins by HPLC analysis [AID620277, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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2
[SID103289206]
IC50 0.04Compound was tested for in vitro inhibition on human PMNL. [AID160514, Type: Literature]
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3
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC method [AID592364, Type: Literature]
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4
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production preincubated for 15 mins measured after 10 mins by HPLC method [AID592365, Type: Literature]
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5
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in S100 cell free fraction of human polymorphonuclear leukocytes assessed as reduction in 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis [AID650763, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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6
[SID103289206]
IC50 0.05Inhibition of 5-lipooxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis [AID661903, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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7
[SID103289206]
IC50 0.06Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils after 15 mins by HPLC analysis in presence of A23187 [AID620273, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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8
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as reduction in A23187 and AA-stimulated 5-LO product formation preincubated for 15 mins prior stimulation measured after 10 mins by HPLC analysis [AID650762, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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9
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated 15 mins by RP-HPLC analysis in presence of exogenous arachidonic acid [AID598671, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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10
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC method [AID592362, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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11
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production preincubated for 15 mins measured after 10 mins by HPLC method [AID592363, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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12
[SID103289206]
IC50 0.1Compound was tested for in vitro inhibition on rat whole blood. [AID92727, Type: Literature]
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13
[SID103289206]
IC50 0.1Compound was tested for in vitro inhibition on broken human PMNL [AID166521, Type: Literature]
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14
[SID103289206]
IC50 0.11Inhibition of 5-LO in PMNL cells [AID413196, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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15
[SID103289206]
IC50 0.11Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assay [AID596918, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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16
[SID103289206]
IC50 0.11Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 mins [AID665660, Type: Literature]Arachidonate 5-lipoxygenase-activating protein [gi:120267]
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17
[SID103289206]
IC50 0.14Inhibition of 5-lipooxygenase in human polynuclear leukocytes assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis [AID661902, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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18
[SID103289206]
IC50 0.14In vitro inhibition of 5-lipoxygenase from human polymorphs [AID6704, Type: Literature]
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19
[SID103289206]
IC50 0.14The compound was tested for inhibitory activity against 5-Lipoxygenase in human polymorphonuclear leukocytes[PMNS] [AID3628, Type: Literature]
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20
[SID103289206]
IC50 0.16Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli BL21 assessed as enzyme product formation using using arachidonic acid as substrate after 10 mins by RP-HPLC analysis [AID598673, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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21
[SID103289206]
IC50 0.16Inhibition of human recombinant 5-LO expressed in Escherichia coli by cell-free assay [AID412945, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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22
[SID103289206]
IC50 0.2Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli MV1190 assessed as suppression of A23187-induced product formation [AID362902, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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23
[SID103289206]
IC50 0.36Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assay [AID596916, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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24
[SID103289206]
IC50 3Inhibition of 5-lipoxygenase in human PMNL [AID578382, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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25
[SID103289206]
IC50 3.2In vitro inhibition of Prostaglandin G/H synthase from human polymorphs [AID160720, Type: Literature]
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26
[SID103289206]
IC50 0.01Inhibition of human recombinant COX2 [AID413191, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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27
[SID103289206]
IC50 0.01Inhibition of ovine COX1 [AID412948, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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28
[SID103289206]
IC50 30Cytotoxicity against human U937 cells assessed as cell viability after 48 hrs by WST-1 assay [AID661906, Type: Literature]
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29
[SID103289206]
 Cytotoxicity against human U937 cells assessed as LDH leakage at 30 uM after 48 hrs by microplate reader assay relative to control [AID661907, Type: Literature]
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30
[SID103289206]
 Inhibition of 5-lipooxygenase in human polynuclear leukocytes assessed as residual activity at 10 uM preincubated for 15 mins measured after 10 mins by HPLC analysis relative to control [AID661904, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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31
[SID103289206]
 Inhibition of 5-lipooxygenase in cell free S100 freshly isolated human PMNL cells assessed as assessed as residual activity at 10 uM preincubated for 15 mins measured after 10 mins by HPLC analysis relative to control [AID661905, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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32
[SID103289206]
 Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production at 0.3 uM after 10 mins by RP-HPLC assay [AID596921, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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33
[SID103289206]
 Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production at 0.3 uM after 10 mins by RP-HPLC assay [AID596922, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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34
[SID103289206]
 Compound was tested for in vivo inhibition on rat PMNL. [AID160661, Type: Literature]
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35
[SID103289206]
 phase 1 oral half life at a dose 400 mg. [AID19135, Type: Literature]
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36
[SID103289206]
 Compound was tested for in vivo inhibition on gp antigen bronchospasm. [AID76779, Type: Literature]
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37
[SID103289206]
 Inhibition of 5-LOX in A-23187-stimulated PNML at 10 uM [AID267596, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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38
[SID103289206]
 Inhibition of 5-LOX at 10 uM [AID267597, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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39
[SID103289206]
 Inhibition of 5-lipoxygenase in human intact polymorphonuclear leukocytes assessed as suppression of A23187-induced product formation at 1 uM [AID362897, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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40
[SID103289206]
 Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli MV1190 assessed as suppression of A23187-induced product formation at 1 uM [AID362900, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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41
[SID103289206]
 Inhibition of 5-LO in human PMNL cells at 1 uM relative to control [AID412943, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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42
[SID103289206]
 Inhibition of human FLAP in cell-free system assessed as inhibition of 5-LO product formation at 10 uM preincubated for 15 mins measured after 10 mins relative to control [AID665661, Type: Literature]Arachidonate 5-lipoxygenase-activating protein [gi:120267]
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43
[SID103289206]
 Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation at 10 uM preincubated for 15 mins measured after 10 mins relative to control [AID665659, Type: Literature]Arachidonate 5-lipoxygenase-activating protein [gi:120267]
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44
[SID103289206]
 Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils assessed as residual activity at 0.3 uM after 15 mins by HPLC analysis in presence of A23187 [AID620275, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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45
[SID103289206]
 Inhibition of recombinant human 5-Lipoxygenase expressed in Escherichia coli lysate assessed as residual activity at 0.3 uM after 10 mins by HPLC analysis [AID620276, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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46
[SID29217511]
Potency 4.7444qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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47
[SID29217511]
Potency 4.7444qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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48
[SID29217511]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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49
[SID29217511]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein [Homo sapiens] [gi:4557365]
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50
[SID29217511]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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