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N-(3-phenoxycinnamyl)acetohydroxamic acid (CID 6438354) - Compound BioActivity Data
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BioActivity Outcomes:
Active(28)
 
 
Inactive(29)
 
 
Inconclusive(5)
 
 
Unspecified(24)
 
 
Top Targets:
Lipoxygenase(34)
 
 
 
MAPEG(7)
 
 
 
 
 
prostaglandin..(2)
 
 
Bromo ALL-1(2)
 
 
Menin(2)
 
 
BioAssay Types:
Literature(56)
 
 
 
 
 
Confirmatory(25)
 
 
 
Screening(5)
 
 
BioActivity Types:
IC50(34)
 
 
 
 
Potency(25)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 82    Data Row: 86   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103289206]
IC50 0.038Inhibition of recombinant human 5-Lipoxygenase expressed in Escherichia coli lysate after 10 mins by HPLC analysis [AID620277, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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2
[SID103289206]
IC50 0.04Compound was tested for in vitro inhibition on human PMNL. [AID160514, Type: Literature]
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3
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC method [AID592364, Type: Literature]
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4
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production preincubated for 15 mins measured after 10 mins by HPLC method [AID592365, Type: Literature]
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5
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in S100 cell free fraction of human polymorphonuclear leukocytes assessed as reduction in 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis [AID650763, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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6
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis [AID661903, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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7
[SID103289206]
IC50 0.06Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils after 15 mins by HPLC analysis in presence of A23187 [AID620273, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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8
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC method [AID592362, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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9
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production preincubated for 15 mins measured after 10 mins by HPLC method [AID592363, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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10
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated 15 mins by RP-HPLC analysis in presence of exogenous arachidonic acid [AID598671, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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11
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challenge [AID700862, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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12
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as reduction in A23187 and AA-stimulated 5-LO product formation preincubated for 15 mins prior stimulation measured after 10 mins by HPLC analysis [AID650762, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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13
[SID103289206]
IC50 0.1Compound was tested for in vitro inhibition on broken human PMNL [AID166521, Type: Literature]
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14
[SID103289206]
IC50 0.1Compound was tested for in vitro inhibition on rat whole blood. [AID92727, Type: Literature]
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15
[SID103289206]
IC50 0.11Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 mins [AID665660, Type: Literature]Arachidonate 5-lipoxygenase-activating protein [gi:120267]
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16
[SID103289206]
IC50 0.11Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assay [AID596918, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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17
[SID103289206]
IC50 0.11Inhibition of 5-LO in PMNL cells [AID413196, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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18
[SID103289206]
IC50 0.14Inhibition of 5-lipoxygenase in human polynuclear leukocytes assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis [AID661902, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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19
[SID103289206]
IC50 0.14The compound was tested for inhibitory activity against 5-Lipoxygenase in human polymorphonuclear leukocytes[PMNS] [AID3628, Type: Literature]
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20
[SID103289206]
IC50 0.14In vitro inhibition of 5-lipoxygenase from human polymorphs [AID6704, Type: Literature]
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