Bookmark and Share

BioActivity Data for Compound N-(3-phenoxycinnamyl)acetohydroxamic acid (CID 6438354)

BioActivity Outcomes:
Active(35)
 
 
Inactive(29)
 
 
Inconclusive(8)
 
 
Unspecified(24)
 
 
Top Targets:
Lipoxygenase(41)
 
 
 
MAPEG(8)
 
 
 
 
 
ePHD KMT2A(2)
 
 
SLT beta(2)
 
 
RIP(2)
 
 
BioAssay Types:
Literature(66)
 
 
 
 
 
Confirmatory(25)
 
 
 
Screening(5)
 
 
BioAssay Categories:
In vitro(5)
 
 
In vivo(3)
 
 
Biochemical(56)
 
 
 
 
 
Toxicity(2)
 
 
ADME(3)
 
 
Cell-based(19)
 
 
 
BioActivity Types:
IC50(42)
 
 
 
 
Potency(25)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 92    Data Row: 96   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103289206]
IC50 0.013Inhibition of 5-LO-mediated LTB4 formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition measured after 30 mins by UPLC-MS/MS analysis [AID1155590, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
2
[SID103289206]
IC50 0.013Inhibition of 5-LO-mediated 5-HETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition measured after 30 mins by UPLC-MS/MS analysis [AID1155591, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
3
[SID103289206]
IC50 0.013Inhibition of 5-LO-mediated 5,12-DiHETE formation in LPS-stimulated human monocytes preincubated for 15 mins before arachidonic acid substrate addition measured after 30 mins by UPLC-MS/MS analysis [AID1155592, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
4
[SID103289206]
IC50 0.02Inhibition of human recombinant 5-LO expressed in Escherichia coli Bl21 (DE3) using arachidonic acid as substrate preincubated for 10 mins measured after 10 mins by RP-HPLC analysis [AID1155573, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
5
[SID103289206]
IC50 0.038Inhibition of recombinant human 5-Lipoxygenase expressed in Escherichia coli lysate after 10 mins by HPLC analysis [AID620277, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
6
[SID103289206]
IC50 0.04Compound was tested for in vitro inhibition on human PMNL. [AID160514, Type: Literature]
View
7
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production preincubated for 15 mins measured after 10 mins by HPLC method [AID592365, Type: Literature]
View
8
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC method [AID592364, Type: Literature]
View
9
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in S100 cell free fraction of human polymorphonuclear leukocytes assessed as reduction in 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis [AID650763, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
10
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis [AID661903, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
11
[SID103289206]
IC50 0.05Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate preincubated for 15 mins measured after 10 mins by HPLC analysis [AID1155574, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
12
[SID103289206]
IC50 0.06Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils after 15 mins by HPLC analysis in presence of A23187 [AID620273, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
13
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production preincubated for 15 mins measured after 10 mins by HPLC method [AID592363, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
14
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challenge [AID700862, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
15
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as reduction in A23187 and AA-stimulated 5-LO product formation preincubated for 15 mins prior stimulation measured after 10 mins by HPLC analysis [AID650762, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
16
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated 15 mins by RP-HPLC analysis in presence of exogenous arachidonic acid [AID598671, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
17
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC method [AID592362, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
View
18
[SID103289206]
IC50 0.1Compound was tested for in vitro inhibition on broken human PMNL [AID166521, Type: Literature]
View
19
[SID103289206]
IC50 0.1Compound was tested for in vitro inhibition on rat whole blood. [AID92727, Type: Literature]
View
20
[SID103289206]
IC50 0.11Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 mins [AID665660, Type: Literature]Arachidonate 5-lipoxygenase-activating protein [gi:120267]
View