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N-(3-phenoxycinnamyl)acetohydroxamic acid (CID 6438354) - Compound BioActivity Data
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BioActivity Outcomes:
Active(28)
 
 
Inactive(29)
 
 
Inconclusive(5)
 
 
Unspecified(24)
 
 
Top Targets:
Lipoxygenase(34)
 
 
 
MAPEG(7)
 
 
 
 
 
prostaglandin..(2)
 
 
Bromo ALL-1(2)
 
 
Menin(2)
 
 
BioAssay Types:
Literature(56)
 
 
 
 
 
Confirmatory(25)
 
 
 
Screening(5)
 
 
BioActivity Types:
IC50(34)
 
 
 
 
Potency(25)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 82    Data Row: 86   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103289206]
IC50 0.038Inhibition of recombinant human 5-Lipoxygenase expressed in Escherichia coli lysate after 10 mins by HPLC analysis [AID620277, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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2
[SID103289206]
IC50 0.04Compound was tested for in vitro inhibition on human PMNL. [AID160514, Type: Literature]
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3
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC method [AID592364, Type: Literature]
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4
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production preincubated for 15 mins measured after 10 mins by HPLC method [AID592365, Type: Literature]
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5
[SID103289206]
IC50 0.05Inhibition of 5-lipoxygenase in S100 cell free fraction of human polymorphonuclear leukocytes assessed as reduction in 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis [AID650763, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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6
[SID103289206]
IC50 0.05Inhibition of 5-lipooxygenase in cell free S100 freshly isolated human PMNL cells assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis [AID661903, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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7
[SID103289206]
IC50 0.06Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils after 15 mins by HPLC analysis in presence of A23187 [AID620273, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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8
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC method [AID592362, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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9
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production preincubated for 15 mins measured after 10 mins by HPLC method [AID592363, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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10
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated 15 mins by RP-HPLC analysis in presence of exogenous arachidonic acid [AID598671, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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11
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challenge [AID700862, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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12
[SID103289206]
IC50 0.08Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as reduction in A23187 and AA-stimulated 5-LO product formation preincubated for 15 mins prior stimulation measured after 10 mins by HPLC analysis [AID650762, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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13
[SID103289206]
IC50 0.1Compound was tested for in vitro inhibition on broken human PMNL [AID166521, Type: Literature]
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14
[SID103289206]
IC50 0.1Compound was tested for in vitro inhibition on rat whole blood. [AID92727, Type: Literature]
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15
[SID103289206]
IC50 0.11Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 mins [AID665660, Type: Literature]Arachidonate 5-lipoxygenase-activating protein [gi:120267]
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16
[SID103289206]
IC50 0.11Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assay [AID596918, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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17
[SID103289206]
IC50 0.11Inhibition of 5-LO in PMNL cells [AID413196, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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18
[SID103289206]
IC50 0.14Inhibition of 5-lipooxygenase in human polynuclear leukocytes assessed as inhibition of A23187-stimulated 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis [AID661902, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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19
[SID103289206]
IC50 0.14The compound was tested for inhibitory activity against 5-Lipoxygenase in human polymorphonuclear leukocytes[PMNS] [AID3628, Type: Literature]
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20
[SID103289206]
IC50 0.14In vitro inhibition of 5-lipoxygenase from human polymorphs [AID6704, Type: Literature]
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21
[SID103289206]
IC50 0.16Inhibition of human recombinant 5-lipoxygenase-mediated product formation from arachidonic acid after 5 to 10 mins by HPLC analysis [AID700992, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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22
[SID103289206]
IC50 0.16Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli BL21 assessed as enzyme product formation using using arachidonic acid as substrate after 10 mins by RP-HPLC analysis [AID598673, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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23
[SID103289206]
IC50 0.16Inhibition of 5-lipoxygenase in A23187-stimulated human neutrophils assessed as inhibition of enzyme product formation by RP-HPLC analysis [AID703844, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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24
[SID103289206]
IC50 0.16Inhibition of human recombinant 5-LO expressed in Escherichia coli by cell-free assay [AID412945, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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25
[SID103289206]
IC50 0.2Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli MV1190 assessed as suppression of A23187-induced product formation [AID362902, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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26
[SID103289206]
IC50 0.36Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assay [AID596916, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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27
[SID103289206]
IC50 3Inhibition of 5-lipoxygenase in human PMNL [AID578382, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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28
[SID103289206]
IC50 3.2In vitro inhibition of Prostaglandin G/H synthase from human polymorphs [AID160720, Type: Literature]
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29
[SID103289206]
IC50 0.01Inhibition of human recombinant COX2 [AID413191, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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30
[SID103289206]
IC50 0.01Inhibition of ovine COX1 [AID412948, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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31
[SID103289206]
IC50 30Cytotoxicity against human U937 cells assessed as cell viability after 48 hrs by WST-1 assay [AID661906, Type: Literature]
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32
[SID103289206]
Cytotoxicity against human U937 cells assessed as LDH leakage at 30 uM after 48 hrs by microplate reader assay relative to control [AID661907, Type: Literature]
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33
[SID103289206]
Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation at 10 uM preincubated for 15 mins measured after 10 mins relative to control [AID665659, Type: Literature]Arachidonate 5-lipoxygenase-activating protein [gi:120267]
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34
[SID103289206]
Inhibition of human FLAP in cell-free system assessed as inhibition of 5-LO product formation at 10 uM preincubated for 15 mins measured after 10 mins relative to control [AID665661, Type: Literature]Arachidonate 5-lipoxygenase-activating protein [gi:120267]
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35
[SID103289206]
phase 1 oral half life at a dose 400 mg. [AID19135, Type: Literature]
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36
[SID103289206]
Compound was tested for in vivo inhibition on gp antigen bronchospasm. [AID76779, Type: Literature]
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37
[SID103289206]
Compound was tested for in vivo inhibition on rat PMNL. [AID160661, Type: Literature]
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38
[SID103289206]
Inhibition of 5-lipooxygenase in human polynuclear leukocytes assessed as residual activity at 10 uM preincubated for 15 mins measured after 10 mins by HPLC analysis relative to control [AID661904, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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39
[SID103289206]
Inhibition of 5-lipooxygenase in cell free S100 freshly isolated human PMNL cells assessed as assessed as residual activity at 10 uM preincubated for 15 mins measured after 10 mins by HPLC analysis relative to control [AID661905, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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40
[SID103289206]
Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production at 0.3 uM after 10 mins by RP-HPLC assay [AID596921, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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41
[SID103289206]
Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production at 0.3 uM after 10 mins by RP-HPLC assay [AID596922, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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42
[SID103289206]
Competitive inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated up to 10 uM for 15 mins by RP-HPLC analysis [AID701003, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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43
[SID103289206]
Competitive inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated up to 10 uM for 15 mins by RP-HPLC analysis in presence of 20 uM exogenous arachidonic acid [AID701004, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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44
[SID103289206]
Competitive inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated up to 10 uM for 15 mins by RP-HPLC analysis in presence of 40 uM exogenous arachidonic acid [AID701005, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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45
[SID103289206]
Competitive inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated up to 10 uM for 15 mins by RP-HPLC analysis in presence of 60 uM exogenous arachidonic acid [AID701006, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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46
[SID103289206]
Inhibition of 5-LO in human PMNL cells at 1 uM relative to control [AID412943, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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47
[SID103289206]
Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils assessed as residual activity at 0.3 uM after 15 mins by HPLC analysis in presence of A23187 [AID620275, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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48
[SID103289206]
Inhibition of recombinant human 5-Lipoxygenase expressed in Escherichia coli lysate assessed as residual activity at 0.3 uM after 10 mins by HPLC analysis [AID620276, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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49
[SID103289206]
Inhibition of 5-LOX in A-23187-stimulated PNML at 10 uM [AID267596, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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50
[SID103289206]
Inhibition of 5-LOX at 10 uM [AID267597, Type: Literature]Arachidonate 5-lipoxygenase [gi:126407]
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