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cinalukast (CID 6436135) - Compound BioActivity Data
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BioActivity Outcomes:
Active(16)
 
 
Inactive(222)
 
 
Inconclusive(33)
 
 
Unspecified(2)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
 
NR LBD ER(7)
 
 
 
NR LBD AR(7)
 
 
 
NR LBD TR(5)
 
 
 
P53(5)
 
 
 
BioAssay Types:
Confirmatory(147)
 
 
 
 
Literature(64)
 
 
 
 
 
Screening(38)
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(162)
 
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 206    Data Row: 273   Total Pages: 14   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103188344]
Ki 0.0064Binding affinity towards Cysteinyl leukotriene D4 receptor (cysLT1) was measured by the displacement of [3H]LTD4 radioligand [AID55069, Type: Literature]Cysteinyl leukotriene receptor 1 [gi:123779610]
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2
[SID26753192]
Potency 5.7255Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID26753192]
Potency 6.3096qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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4
[SID144204742]
AhR Potency (uM) 8.09594qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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5
[SID144204742]
Potency-Replicate_1 8.4127qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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6
[SID26753192]
Potency 12.5893qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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7
[SID26753192]
Potency 12.5893qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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8
[SID170466361]
Ratio Potency (uM) 23.7083qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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9
[SID26753192]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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10
[SID26753192]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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11
[SID144204742]
Potency-Replicate_1 27.8159qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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12
[SID144204742]
Ratio Potency (uM) 28.8147qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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13
[SID136949633]
Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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14
[SID136949633]
Fluorescence-based biochemical high throughput confirmation assay to identify molecules that bind r(CAG) RNA repeats [AID652065, Type: screening]
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15
[SID136949633]
Counterscreen for molecules that bind rCAG RNA repeats: fluorescent based biochemical counterscreen assay for inhibitors of the DNA-based (5'CAG/3'GTC) TO-PRO-1 dye complex [AID652068, Type: screening]
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16
[SID170466361]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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17
[SID103188344]
Antagonistic activity against LTD4 induced contraction in human bronchus [AID91233, Type: Literature]
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18
[SID26753192]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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19
[SID26753192]
Potency 6.3096qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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20
[SID144204742]
Potency 15.8489qHTS Assay for Identifying Gametocytocidal Compounds [AID743244, Type: confirmatory]
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