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avermectin B(1)a (CID 6434889) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(79)
 
 
Inactive(72)
 
 
Inconclusive(70)
 
 
Unspecified(359)
 
 
Top Targets:
7tm 4(33)
 
 
 
 
NR LBD ER(18)
 
 
 
 
 
NR LBD AR(17)
 
 
 
 
 
NR LBD PPAR(15)
 
 
 
 
p450(12)
 
 
 
 
 
BioAssay Types:
Confirmatory(257)
 
 
 
 
 
Literature(122)
 
 
 
Summary(39)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(172)
 
 
 
 
IC50(116)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 513    Data Row: 580   Total Pages: 29   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124963713]
IC50 0.132DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) [AID625268, Type: confirmatory]
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2
[SID124963713]
IC50 0.87DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: confirmatory]Adenosine receptor A3 [gi:1351831]
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3
[SID144211158]
Potency-Replicate_1 3.2181qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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4
[SID144211158]
Potency-Replicate_1 3.2181qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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5
[SID144211158]
Potency-Replicate_1 3.6108qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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6
[SID144211158]
Potency-Replicate_1 3.6427qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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7
[SID124963713]
EC50 4Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BESM cells measured after 88 hrs postinfection by HTS assay [AID547622, Type: Literature]
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8
[SID144211158]
Ratio Potency (uM) 4.08715qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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9
[SID144211158]
Potency-Replicate_1 4.5859qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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10
[SID144211158]
Ratio Potency (uM) 6.06178qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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11
[SID144211158]
Ratio Potency (uM) 6.11533qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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12
[SID124963713]
IC50 6.119DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: confirmatory]D(1A) dopamine receptor [gi:118228]
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13
[SID144211158]
Potency-Replicate_1 6.421qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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14
[SID144211158]
Potency-Replicate_1 7.2681qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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15
[SID144211158]
Potency-Replicate_1 9.15qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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16
[SID144211158]
Potency-Replicate_1 9.15qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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17
[SID144211158]
Potency-Replicate_1 10.1765qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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18
[SID144211158]
Potency-Replicate_1 10.2664qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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19
[SID144211158]
Potency-Replicate_1 10.2664qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway [AID743215, Type: confirmatory]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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20
[SID144211158]
Potency-Replicate_1 11.4183qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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