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tert-Butylhydroperoxide (CID 6410) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Inactive(396)
 
 
Inconclusive(16)
 
 
Unspecified(8)
 
 
Top Targets:
NR LBD PPAR(18)
 
 
 
NR LBD ER(11)
 
 
NR LBD AR(11)
 
 
 
NR LBD TR(11)
 
 
NR LBD VDR(8)
 
 
 
BioAssay Types:
Confirmatory(362)
 
 
 
Summary(24)
 
 
 
Literature(13)
 
 
 
 
BioActivity Types:
Potency(308)
 
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 250    Data Row: 423   Total Pages: 22   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103410454]
Induction of ROS generation in rat liver mitochondria assessed as swelling at 10 uM [AID726456, Type: Literature]
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2
[SID103410454]
Induction of oxidative stress in human U87MG cells assessed as increase in reactive oxygens species generation at 100 uM after 1 hr by H2DCFDA dye based flow cytometry [AID738615, Type: Literature]
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3
[SID103410454]
Induction of oxidative stress in human 1321N1 cells assessed as increase in reactive oxygens species generation at 100 uM after 1 hr by H2DCFDA dye based flow cytometry [AID738616, Type: Literature]
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4
[SID103410454]
IC50 203In vitro antimalarial activity against Plasmodium falciparum D6 [AID159623, Type: Literature]
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5
[SID103410454]
IC50 240In vivo antimalarial activity against Plasmodium falciparum W-2 [AID159759, Type: Literature]
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6
[SID103410454]
Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 300 uM by MTT assay [AID638017, Type: Literature]
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7
[SID17388707]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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8
[SID17388708]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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9
[SID103410454]
Compound was evaluated for (T-C) survival time of the treated mice (Mus musculus) against Plasmodium berghei at 160 mg/kg [AID136544, Type: Literature]
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10
[SID103410454]
Compound was evaluated for (T-C) survival time of the treated mice (Mus musculus) against Plasmodium berghei at 40 mg/Kg [AID136545, Type: Literature]
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11
[SID103410454]
Compound was evaluated for (T-C) survival time of the treated mice (Mus musculus) against Plasmodium berghei at 640 mg/kg [AID136546, Type: Literature]
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12
[SID144208036]
Potency-Replicate_1 48.5577qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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13
[SID17388708]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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14
[SID17388708]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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15
[SID17388707]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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16
[SID17388707]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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17
[SID17388707]
Potency qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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18
[SID17388707]
Potency qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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19
[SID17388708]
Potency qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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20
[SID17388708]
Potency qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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