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BioActivity Data for Compound tert-Butylhydroperoxide (CID 6410)

BioActivity Outcomes:
Active(3)
 
 
Inactive(403)
 
 
Inconclusive(17)
 
 
Unspecified(8)
 
 
Top Targets:
NR LBD PPAR(18)
 
 
 
NR LBD TR(11)
 
 
NR LBD ER(11)
 
 
NR LBD AR(11)
 
 
 
P53(8)
 
 
 
BioAssay Types:
Confirmatory(368)
 
 
 
Summary(26)
 
 
 
Literature(13)
 
 
 
 
BioAssay Categories:
In vitro(1)
 
 
In vivo(1)
 
 
Toxicity(67)
 
 
 
 
ADME(1)
 
 
Cell-based(3)
 
 
 
BioActivity Types:
Potency(316)
 
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 258    Data Row: 431   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103410454]
Induction of ROS generation in rat liver mitochondria assessed as swelling at 10 uM [AID726456, Type: Literature]
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2
[SID103410454]
Induction of oxidative stress in human U87MG cells assessed as increase in reactive oxygens species generation at 100 uM after 1 hr by H2DCFDA dye based flow cytometry [AID738615, Type: Literature]
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3
[SID103410454]
Induction of oxidative stress in human 1321N1 cells assessed as increase in reactive oxygens species generation at 100 uM after 1 hr by H2DCFDA dye based flow cytometry [AID738616, Type: Literature]
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4
[SID103410454]
IC50 203In vitro antimalarial activity against Plasmodium falciparum D6 [AID159623, Type: Literature]
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5
[SID103410454]
IC50 240In vivo antimalarial activity against Plasmodium falciparum W-2 [AID159759, Type: Literature]
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6
[SID103410454]
Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 300 uM by MTT assay [AID638017, Type: Literature]
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7
[SID17388707]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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8
[SID17388708]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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9
[SID103410454]
Compound was evaluated for (T-C) survival time of the treated mice (Mus musculus) against Plasmodium berghei at 160 mg/kg [AID136544, Type: Literature]
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10
[SID103410454]
Compound was evaluated for (T-C) survival time of the treated mice (Mus musculus) against Plasmodium berghei at 40 mg/Kg [AID136545, Type: Literature]
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11
[SID103410454]
Compound was evaluated for (T-C) survival time of the treated mice (Mus musculus) against Plasmodium berghei at 640 mg/kg [AID136546, Type: Literature]
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12
[SID144208036]
Potency-Replicate_1 48.5577qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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13
[SID144208036]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the endoplasmic reticulum stress response signaling pathway: Summary [AID1159519, Type: summary]activating transcription factor 6 [Homo sapiens] [gi:119611100]
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14
[SID144208036]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the endoplasmic reticulum stress response signaling pathway [AID1159516, Type: confirmatory]activating transcription factor 6 [Homo sapiens] [gi:119611100]
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15
[SID144208036]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the NFkB signaling pathway: Summary [AID1159518, Type: summary]nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a [Homo sapiens] [gi:119626539]
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16
[SID144208036]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the endoplasmic reticulum stress response signaling pathway - cell viability counter screen [AID1159517, Type: confirmatory]
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17
[SID144208036]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway - cell viability counter screen [AID1159520, Type: confirmatory]
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18
[SID17388708]
Potency qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]interleukin 8 [Homo sapiens] [gi:186368]
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19
[SID17388708]
Potency-Replicate_1 qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway measured by Nrf2-dependant transcriptional activity [AID720636, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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20
[SID17388708]
Potency qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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