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SMR000046397 (CID 6400963) - Compound BioActivity Data
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BioActivity Outcomes:
Active(24)
 
 
Inactive(795)
 
 
Inconclusive(21)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(27)
 
 
 
7TM GPCR Srsx(24)
 
 
 
Bcl-2 like(18)
 
 
 
alkPPc(14)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(535)
 
 
 
 
Confirmatory(271)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(171)
 
 
 
 
 
IC50(51)
 
 
 
EC50(22)
 
 
AC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 770    Data Row: 842   Total Pages: 43   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID864135]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID864135]
Potency 14.1254qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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3
[SID864135]
Potency 15.8489qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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4
[SID864135]
IC50_Artemis_Mean 19.8Dose Response confirmation of small molecule inhibitors originally identified via uHTS of Artemis endonuclease activity via a fluorescence intensity assay [AID720701, Type: confirmatory]protein artemis isoform a [Homo sapiens] [gi:76496497]
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5
[SID864135]
Potency 25.1189qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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6
[SID864135]
Potency 56.2341qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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7
[SID864135]
uHTS for 14-3-3/Bad interaction inhibitors [AID781, Type: screening]14-3-3 protein zeta/delta [Bos taurus] [gi:27807367]
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8
[SID864135]
HTS for BAP1 Enzyme inhibitors [AID436, Type: screening]Ubiquitin carboxyl-terminal hydrolase BAP1 [gi:68565074]
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9
[SID864135]
Luminescent GLuc Reporter Gene Assay Primary HTS to Identify Small Molecule Activator of Glucose Dependent Insulin Secretion Measured in Cell-Based System Using Plate Reader - 7055-01_Activator_SinglePoint_HTS_Activity [AID743287, Type: screening]
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10
[SID864135]
Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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11
[SID864135]
Allosteric Modulators of D1 Receptors: Confirmation Screen [AID642, Type: other]
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12
[SID864135]
Cell signaling CRE-BLA (Fsk stim) [AID662, Type: confirmatory]
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13
[SID864135]
Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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14
[SID864135]
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-2. [AID950, Type: screening]Apoptosis regulator Bcl-2 [gi:231632]
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15
[SID864135]
HIV-1 RT-RNase H MLSCN HTS MH077605 [AID565, Type: screening]Chain A, High Resolution Structures Of Hiv-1 Rt From Four Rt- Inhibitor Complexes [gi:1431733]
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16
[SID864135]
uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID588458, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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17
[SID864135]
Allosteric Modulators of D1 Receptors: Secondary Assay 2 [AID647, Type: other]
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18
[SID864135]
Counterscreen assay for antagonists of neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. [AID1256, Type: screening]neuropeptide Y receptor type 1 [Homo sapiens] [gi:4505445]
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19
[SID864135]
Cell-based high throughput confirmation assay for antagonists of neuropeptide Y receptor Y2 (NPY-Y2) [AID1257, Type: screening]neuropeptide Y receptor type 2 [Homo sapiens] [gi:4505447]
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20
[SID864135]
Primary cell based high-throughput screening assay for antagonists of neuropeptide Y receptor Y2 (NPY-Y2) [AID793, Type: screening]neuropeptide Y receptor type 2 [Homo sapiens] [gi:4505447]
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