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Squalene (CID 638072) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inactive(213)
 
 
Inconclusive(9)
 
 
Unspecified(11)
 
 
Top Targets:
NR LBD AR(14)
 
 
NR LBD ER(14)
 
 
NR LBD GR(8)
 
 
 
NR LBD TR(6)
 
 
NR LBD PPAR(4)
 
 
BioAssay Types:
Confirmatory(127)
 
 
 
Literature(73)
 
 
 
 
 
Summary(30)
 
 
Screening(4)
 
 
BioActivity Types:
Potency(152)
 
 
 
IC50(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 106    Data Row: 235   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103601286]
Km 3.8Activity of C-terminal hexahistidine-tagged rat recombinant squalene epoxidase without N-terminal putative membrane domain expressed in Escherichia coli [AID357309, Type: Literature]Squalene monooxygenase [gi:1706689]
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2
[SID50125918]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_49, Type: Literature]
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3
[SID103601286]
IC50 30Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced superoxide anion generation treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge by spectrophotometry [AID422001, Type: Literature]
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4
[SID103601286]
IC50 30Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge [AID422002, Type: Literature]
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5
[SID103601286]
IC50 50Cytotoxicity against human MCF7 cells after 72 hrs by MTS reduction assay [AID502768, Type: Literature]
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6
[SID103601286]
IC50 50Cytotoxicity against human NCI-H460 cells after 72 hrs by MTS reduction assay [AID502769, Type: Literature]
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7
[SID103601286]
IC50 50Cytotoxicity against human SF268 cells after 72 hrs by MTS reduction assay [AID502770, Type: Literature]
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8
[SID50125918]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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9
[SID103601286]
Antitubercular activity against Mycobacterium tuberculosis H37Rv after 2 weeks [AID422404, Type: Literature]
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10
[SID103601286]
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by MTT assay after 4 days by MTT assay [AID362655, Type: Literature]
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11
[SID103601286]
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 100 ug/ml after 4 days by MTT assay [AID362656, Type: Literature]
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12
[SID103601286]
Antimycobacterial activity against Mycobacterium tuberculosis 90-221387 [AID713902, Type: Literature]
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13
[SID103601286]
Antiamoebic activity against Entamoeba histolytica [AID1097036, Type: other]
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14
[SID144206790]
Potency-Replicate_1 8.4852qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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15
[SID144206342]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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16
[SID144206790]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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17
[SID144206342]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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18
[SID144206790]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
19
[SID144206342]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
20
[SID144206790]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View