Squalene (CID 638072) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(2)
 
 
Inactive(92)
 
 
Inconclusive(4)
 
 
Unspecified(9)
 
 
Top Targets:
DUF3652(2)
 
 
Geminin(2)
 
 
Menin(2)
 
 
NR LBD ROR li..(2)
 
 
PMP22 Claudin(2)
 
 
BioAssay Types:
Literature(72)
 
 
 
 
 
Confirmatory(31)
 
 
 
Screening(4)
 
 
BioActivity Types:
Potency(30)
 
 
 
IC50(5)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 42    Data Row: 107   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_49, Type: Literature]
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2
[SID103601286]
 Activity of C-terminal hexahistidine-tagged rat recombinant squalene epoxidase without N-terminal putative membrane domain expressed in Escherichia coli [AID357309, Type: Literature]Squalene monooxygenase [gi:1706689]
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3
[SID103601286]
IC50 30Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced superoxide anion generation treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge by spectrophotometry [AID422001, Type: Literature]
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4
[SID103601286]
IC50 30Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge [AID422002, Type: Literature]
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5
[SID103601286]
IC50 50Cytotoxicity against human MCF7 cells after 72 hrs by MTS reduction assay [AID502768, Type: Literature]
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6
[SID103601286]
IC50 50Cytotoxicity against human NCI-H460 cells after 72 hrs by MTS reduction assay [AID502769, Type: Literature]
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7
[SID103601286]
IC50 50Cytotoxicity against human SF268 cells after 72 hrs by MTS reduction assay [AID502770, Type: Literature]
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8
[SID103601286]
MIC 122Antitubercular activity against Mycobacterium tuberculosis H37Rv after 2 weeks [AID422404, Type: Literature]
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9
[SID103601286]
 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by MTT assay after 4 days by MTT assay [AID362655, Type: Literature]
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10
[SID103601286]
 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 100 ug/ml after 4 days by MTT assay [AID362656, Type: Literature]
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11
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
View
12
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_1, Type: Literature]
View
13
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_2, Type: Literature]
View
14
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_4, Type: Literature]
View
15
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_5, Type: Literature]
View
16
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_6, Type: Literature]
View
17
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_7, Type: Literature]
View
18
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_8, Type: Literature]
View
19
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_9, Type: Literature]
View
20
[SID50125918]
Potency S16 Schwann cell viability assay (CellTiter-Glo assay) [AID624031, Type: confirmatory]
View
21
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_11, Type: Literature]
View
22
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_12, Type: Literature]
View
23
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_13, Type: Literature]
View
24
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_14, Type: Literature]
View
25
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_15, Type: Literature]
View
26
[SID50125918]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_16, Type: Literature]
View
27
[SID103601286]
 Antimycobacterial activity against Mycobacterium tuberculosis H37Ra at 200 ug/ml after 4 days by MTT assay [AID362657, Type: Literature]
View
28
[SID50125918]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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29
[SID50125918]
Potency A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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30
[SID50125918]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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31
[SID50125918]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
View
32
[SID144206342]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
33
[SID144206342]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
34
[SID144206342]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
35
[SID144206342]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
36
[SID144206342]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
37
[SID144206342]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
38
[SID144206790]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
39
[SID144206790]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
40
[SID144206790]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
41
[SID144206790]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
42
[SID144206790]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
43
[SID144206790]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
44
[SID50125918]
Potency qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase: hit validation [AID492961, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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45
[SID50125918]
Potency Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
View
46
[SID50125918]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
View
47
[SID50125918]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
View
48
[SID50125918]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
View
49
[SID50125918]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
View
50
[SID50125918]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View