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piperine (CID 638024) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(51)
 
 
Inactive(644)
 
 
Inconclusive(103)
 
 
Unspecified(110)
 
 
Top Targets:
NR LBD PPAR(21)
 
 
 
 
7TM GPCR Srx(20)
 
 
NR LBD AR(16)
 
 
 
NR LBD ER(16)
 
 
 
 
7TM GPCR Srsx(15)
 
 
BioAssay Types:
Confirmatory(335)
 
 
 
 
 
Screening(321)
 
 
 
Literature(121)
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(354)
 
 
 
 
 
IC50(29)
 
 
 
 
Ki(4)
 
 
 
EC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 752    Data Row: 908   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103217468]
IC50 0.26Inhibition of MAO-B in Sprague-Dawley rat brain homogenate using kynuramine as substrate preincubated for 10 mins measured by fluorimetric assay [AID657238, Type: Literature]Amine oxidase [flavin-containing] B [gi:124028639]
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2
[SID103217468]
IC50 0.404Inhibition of MAO-A in Sprague-Dawley rat brain homogenate using kynuramine as substrate preincubated for 10 mins measured by fluorimetric assay [AID657237, Type: Literature]Amine oxidase [flavin-containing] A [gi:113979]
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3
[SID103217468]
IC50 0.483Inhibition of MAO-B assessed as inhibition of kyneuramine conversion to 4-hydroxyquinoline after 20 mins by fluorescence assay [AID718838, Type: Literature]
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4
[SID144209188]
Potency-Replicate_1 0.6125qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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5
[SID144209188]
Potency-Replicate_1 1.3713qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID144209188]
AhR Potency (uM) 1.79394qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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7
[SID144213063]
AhR Potency (uM) 2.16899qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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8
[SID144213063]
Potency-Replicate_1 2.169qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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9
[SID56463241]
Potency 2.5119qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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10
[SID56463241]
Potency 2.5119qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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11
[SID103217468]
EC50 3.16228Agonist activity at human TRPV1 expressed in tetracycline-stimulated HEK293 cells assessed as increase in intracellular calcium levels by fluorimetric assay [AID478379, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:296452849]
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12
[SID103217468]
Ki 3.19Inhibition of mouse brain MAOB [AID453498, Type: Literature]Amine oxidase [flavin-containing] B [gi:341940629]
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13
[SID144213063]
Potency-Replicate_1 3.8571qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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14
[SID103217468]
IC50 4.91Antiparasitic activity against Trypanosoma cruzi Y amastigotes [AID323759, Type: Literature]
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15
[SID103217468]
IC50 4.91In vitro growth inhibition of amastigotes of Trypanosoma cruzi [AID213667, Type: Literature]
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16
[SID103217468]
IC50 5Antimicrobial activity against Trypanosoma cruzi [AID496817, Type: Literature]
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17
[SID26753730]
Potency 7.0795qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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18
[SID103217468]
IC50 7.31Antiparasitic activity against Trypanosoma cruzi Y epimastigote [AID323757, Type: Literature]
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19
[SID103217468]
IC50 7.36In vitro growth inhibition of epimastigotes of Trypanosoma cruzi [AID213669, Type: Literature]
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20
[SID56463241]
Potency 8.4921qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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21
[SID56463241]
Potency 8.9125qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression [AID624202, Type: confirmatory]BRCA1 [Homo sapiens] [gi:1698399]
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22
[SID144209188]
Potency-Replicate_1 10.8928qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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23
[SID144209188]
ATAD5 Potency (uM) 10.8928qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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24
[SID56463241]
Potency 11.5774qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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25
[SID103217468]
IC50 12Hepatoprotective activity in ddY mouse hepatocytes assessed as inhibition of D-galactosamine/TNFalpha-induced cytotoxicity after 20 hrs by MTT assay relative to untreated control [AID453021, Type: Literature]
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26
[SID26748436]
Potency 12.5893qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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27
[SID26748436]
Potency 14.1254qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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28
[SID26753730]
Potency 14.1254qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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29
[SID26748436]
Potency 15.8489qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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30
[SID144213063]
Ratio Potency (uM) 17.903qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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31
[SID103217468]
Ki 19Inhibition of mouse brain MAOA [AID453497, Type: Literature]Amine oxidase [flavin-containing] A [gi:341940599]
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32
[SID103217468]
LD50 20.01Cytotoxicity against mouse macrophages after 72 hrs [AID323760, Type: Literature]
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33
[SID26753730]
Potency-Replicate_1 28.1838qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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34
[SID103217468]
IC50 42Cytoprotective activity in mouse L929 cells assessed as inhibition of TNF-alpha-induced cytotoxicity by MTT assay relative to untreated control [AID453033, Type: Literature]
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35
[SID144209188]
Potency-Replicate_1 43.7427qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway [AID743191, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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36
[SID103217468]
Ki 49.3Inhibition of MAOA in rat brain mitochondria [AID453495, Type: Literature]Amine oxidase [flavin-containing] A [gi:113979]
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37
[SID144213063]
Potency-Replicate_1 54.4827qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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38
[SID144213063]
Potency-Replicate_1 54.4827qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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39
[SID144209188]
Potency-Replicate_1 54.5935qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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40
[SID144213063]
Potency-Replicate_1 54.9477qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway [AID743217, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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41
[SID144209188]
Potency-Replicate_1 61.2549qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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42
[SID144209188]
Potency-Replicate_1 61.2549qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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43
[SID144209188]
TR Potency (uM) 71.418qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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44
[SID56463241]
Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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45
[SID144213063]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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46
[SID103217468]
Agonist activity at TRPV1 [AID500214, Type: Literature]
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47
[SID56463241]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint_HTS_Activity [AID588334, Type: screening]
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48
[SID56463241]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Absorbance-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) full deck assay to identify assay artifacts [AID588335, Type: screening]
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49
[SID48414997]
DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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50
[SID56463241]
Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1) [AID504766, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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