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piperine (CID 638024) - Compound BioActivity Data
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BioActivity Outcomes:
Active(48)
 
 
Inactive(660)
 
 
Inconclusive(97)
 
 
Unspecified(112)
 
 
Top Targets:
NR LBD PPAR(21)
 
 
 
 
7TM GPCR Srx(20)
 
 
NR LBD ER(16)
 
 
 
 
NR LBD AR(16)
 
 
 
7TM GPCR Srsx(15)
 
 
BioAssay Types:
Confirmatory(335)
 
 
 
 
 
Screening(322)
 
 
 
Literature(131)
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(354)
 
 
 
 
 
IC50(29)
 
 
 
 
Ki(4)
 
 
 
EC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 755    Data Row: 917   Total Pages: 46   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103217468]
IC50 0.26Inhibition of MAO-B in Sprague-Dawley rat brain homogenate using kynuramine as substrate preincubated for 10 mins measured by fluorimetric assay [AID657238, Type: Literature]Amine oxidase [flavin-containing] B [gi:124028639]
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2
[SID103217468]
IC50 0.404Inhibition of MAO-A in Sprague-Dawley rat brain homogenate using kynuramine as substrate preincubated for 10 mins measured by fluorimetric assay [AID657237, Type: Literature]Amine oxidase [flavin-containing] A [gi:113979]
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3
[SID103217468]
IC50 0.483Inhibition of MAO-B assessed as inhibition of kyneuramine conversion to 4-hydroxyquinoline after 20 mins by fluorescence assay [AID718838, Type: Literature]
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4
[SID144209188]
Potency-Replicate_1 0.6125qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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5
[SID144209188]
Potency-Replicate_1 1.3713qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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6
[SID144209188]
AhR Potency (uM) 1.79394qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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7
[SID144213063]
AhR Potency (uM) 2.16899qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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8
[SID144213063]
Potency-Replicate_1 2.169qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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9
[SID56463241]
Potency 2.5119qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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10
[SID56463241]
Potency 2.5119qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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11
[SID103217468]
EC50 3.16228Agonist activity at human TRPV1 expressed in tetracycline-stimulated HEK293 cells assessed as increase in intracellular calcium levels by fluorimetric assay [AID478379, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:296452849]
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12
[SID103217468]
Ki 3.19Inhibition of mouse brain MAOB [AID453498, Type: Literature]Amine oxidase [flavin-containing] B [gi:341940629]
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13
[SID144213063]
Potency-Replicate_1 3.8571qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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14
[SID103217468]
IC50 4.91Antiparasitic activity against Trypanosoma cruzi Y amastigotes [AID323759, Type: Literature]
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15
[SID103217468]
IC50 4.91In vitro growth inhibition of amastigotes of Trypanosoma cruzi [AID213667, Type: Literature]
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16
[SID103217468]
IC50 5Antimicrobial activity against Trypanosoma cruzi [AID496817, Type: Literature]
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17
[SID26753730]
Potency 7.0795qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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18
[SID103217468]
IC50 7.31Antiparasitic activity against Trypanosoma cruzi Y epimastigote [AID323757, Type: Literature]
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19
[SID103217468]
IC50 7.36In vitro growth inhibition of epimastigotes of Trypanosoma cruzi [AID213669, Type: Literature]
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20
[SID56463241]
Potency 8.4921qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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