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BioActivity Data for Compound piperlonguminine (CID 637858)

BioActivity Outcomes:
Active(60)
 
 
Inactive(473)
 
 
Inconclusive(31)
 
 
Unspecified(21)
 
 
Top Targets:
7tm 4(35)
 
 
 
DUF3371(8)
 
 
 
ANK(7)
 
 
 
 
PP1c bdg(6)
 
 
 
Esterase lipa..(5)
 
 
BioAssay Types:
Screening(337)
 
 
 
 
Confirmatory(200)
 
 
 
 
 
Literature(24)
 
 
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(108)
 
 
 
Toxicity(22)
 
 
 
 
 
ADME(2)
 
 
Cell-based(125)
 
 
 
 
 
Organism-base..(8)
 
 
BioActivity Types:
Potency(162)
 
 
 
 
 
IC50(24)
 
 
 
 
 
AC50(15)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 523    Data Row: 585   Total Pages: 30   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56463583]
Potency 1.8356qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID56463583]
Potency 2.0596qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID26750045]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID56463583]
AC50_uM 2.69HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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5
[SID26750045]
Potency 3.1623qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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6
[SID26750045]
Potency 3.5481qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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7
[SID26750045]
Potency 4.1095qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID56463583]
Potency 4.1095qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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9
[SID56463583]
Potency 5.8048qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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10
[SID103600531]
IC50 5.86Cytotoxicity against human ZR75-30 cells after 72 hrs by MTT assay [AID1158949, Type: Literature]
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11
[SID103600531]
IC50 6.04Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay [AID1158948, Type: Literature]
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12
[SID56463583]
AC50_uM 7.403MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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13
[SID56463583]
AC50_uM 7.403MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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14
[SID56463583]
AC50_uM 7.403MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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15
[SID26750045]
Potency 7.9433VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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16
[SID56463583]
Potency 8.1995A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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17
[SID103600531]
IC50 8.46Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay [AID1158951, Type: Literature]
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18
[SID26750045]
Potency 8.9125qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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19
[SID56463583]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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20
[SID26750045]
Potency 10qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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