sinapinic acid (CID 637775) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(371)
 
 
Unspecified(20)
 
 
Top Targets:
7TM GPCR Srx(9)
 
 
TRP 2(5)
 
 
7TM GPCR Srsx(5)
 
 
KCNQ channel(4)
 
 
alkPPc(4)
 
 
BioAssay Types:
Screening(294)
 
 
 
Confirmatory(69)
 
 
 
Literature(27)
 
 
 
 
BioActivity Types:
Potency(52)
 
 
 
IC50(21)
 
 
 
 
EC50(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 400    Data Row: 400   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103330747]
IC50 4.77Inhibition of lipid peroxidation in Sprague-Dawley rat brain after 30 mins by TBARS assay [AID314540, Type: Literature]
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2
[SID103330747]
IC50 25.7DPPH radical scavenging activity after 180 mins [AID382837, Type: Literature]
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3
[SID103330747]
IC50 28Inhibition of COX2 after 5 mins by spectrophotometric analysis [AID652655, Type: Literature]
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4
[SID103330747]
IC50 39.2Inhibition of COX1 after 5 mins by spectrophotometric analysis [AID652654, Type: Literature]
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5
[SID47193735]
 Fluorescence Intensity-based biochemical primary high throughput confirmation assay to identify activators of kallikrein-7 (K7) zymogen [AID686949, Type: screening]
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6
[SID47193735]
 Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence [AID686952, Type: screening]
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7
[SID47193735]
 HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening]
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8
[SID47193735]
 Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]
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9
[SID47193735]
 HTS for Identification of VLA-4 Allosteric Modulators from MLPCN library [AID2557, Type: screening]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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10
[SID47193735]
 HTS for Identification of VLA-4 Allosteric Modulators from MLPCN library [AID2557, Type: screening]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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11
[SID103330747]
IC50 66Antioxidant activity assessed as residual DPPH radical scavenging activity after 45 mins by spectrophotometrically [AID568834, Type: Literature]
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12
[SID103330747]
IC50 100Inhibitory concentration of compound on nitric oxide (NO) production in lipopolysaccharide activated mouse peritoneal macrophages [AID248765, Type: Literature]
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13
[SID103330747]
EC50 250Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometry [AID590194, Type: Literature]
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14
[SID103330747]
IC50 351Inhibition of mushroom tyrosinase after 25 mins by spectrophotometry [AID590195, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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15
[SID103330747]
 Percent inhibition of nitric oxide (NO) production in lipopolysaccharide activated mouse peritoneal macrophages at 100 uM of compound [AID252044, Type: Literature]
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16
[SID103330747]
 Percentage inhibition against release of beta-hexosaminidase from RBL-2H3 cells at 100 uM from control [AID166551, Type: Literature]
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17
[SID103330747]
 Inhibitory activity of compound was tested against peroxinitrite in collagen type I at concentration 100 uM of each sample was treated with 1.0 mM peroxynitrite [AID219712, Type: Literature]
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18
[SID103330747]
 Inhibitory activity of compound was tested against peroxinitrite in collagen type I with concentration 50 uM of each sample was treated with 1.0 mM peroxynitrite [AID219713, Type: Literature]
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19
[SID103330747]
 Antioxidant activity assessed as DPPH free radical scavenging activity at 0.9 mM after 20 mins [AID342752, Type: Literature]
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20
[SID103330747]
 Antioxidant activity assessed as DPPH free radical scavenging activity at 1.8 mM after 10 mins [AID342753, Type: Literature]
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21
[SID103330747]
 Antioxidant activity assessed as DPPH free radical scavenging activity at 3.6 mM after 20 mins [AID342757, Type: Literature]
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22
[SID103330747]
 Antioxidant activity assessed as DPPH free radical scavenging activity at 3.6 mM after 10 mins [AID342756, Type: Literature]
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23
[SID103330747]
 Antioxidant activity assessed as DPPH free radical scavenging activity at 1.8 mM after 20 mins [AID342755, Type: Literature]
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24
[SID103330747]
 Antioxidant activity assessed as DPPH free radical scavenging activity at 0.9 mM after 10 mins [AID342754, Type: Literature]
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25
[SID103330747]
 Antioxidant activity assessed as trolox equivalents of ABTS radical scavenging activity by TEAC assay [AID568835, Type: Literature]
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26
[SID103330747]
 Antioxidant activity against Cu2+-induced lipid peroxidation in human plasma LDL preincubated for 1 hr before Cu2+ challenge [AID397153, Type: Literature]
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27
[SID103330747]
 DPPH radical scavenging activity assessed as Trolox equivalent antioxidant capacity at 50 uM after 40 mins [AID397183, Type: Literature]
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28
[SID103330747]
 ABTS radical scavenging activity assessed as Trolox equivalent antioxidant capacity at 50 uM by spectrophotometric analysis [AID397184, Type: Literature]
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29
[SID47193735]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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30
[SID47193735]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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31
[SID103330747]
 Effect on human plasma LDL-PLA2 activity by LS-3B fluorescence spectrometry [AID397586, Type: Literature]Platelet-activating factor acetylhydrolase [gi:2497687]
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32
[SID103330747]
 Effect on human plasma LDL-PLA2 activity by LS-3B fluorescence spectrometry [AID397586, Type: Literature]Platelet-activating factor acetylhydrolase [gi:2497687]
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33
[SID47193735]
Potency 3.9811qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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34
[SID47193735]
Potency 15.8489qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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35
[SID47193735]
Potency 25.1189Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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36
[SID47193735]
Potency 25.1189Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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37
[SID47193735]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652017, Type: screening]
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38
[SID47193735]
Potency qHTS of IL-2 Activators [AID652025, Type: confirmatory]
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39
[SID47193735]
 TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide [AID686964, Type: screening]
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40
[SID47193735]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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41
[SID47193735]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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42
[SID47193735]
Potency qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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43
[SID47193735]
 Fluorescence-based biochemical primary high throughput assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID651800, Type: screening]TCRAV4S1 [Homo sapiens] [gi:2358024]
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44
[SID47193735]
Potency qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101 [AID493005, Type: confirmatory]TSG101 gene product [Homo sapiens] [gi:5454140]
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45
[SID47193735]
Potency qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101 [AID493005, Type: confirmatory]TSG101 gene product [Homo sapiens] [gi:5454140]
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46
[SID47193735]
 uHTS identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID485273, Type: screening]UBE2N gene product [Homo sapiens] [gi:4507793]
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47
[SID47193735]
 uHTS identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID485273, Type: screening]UBE2N gene product [Homo sapiens] [gi:4507793]
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48
[SID47193735]
 uHTS identification of SUMO1-mediated protein-protein interactions [AID602429, Type: screening]SUMO-1 [Homo sapiens] [gi:1762973]
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49
[SID47193735]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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50
[SID47193735]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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