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sinapinic acid (CID 637775) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(443)
 
 
Unspecified(20)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
7TM GPCR Srsx(11)
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
Troponin(4)
 
 
BioAssay Types:
Screening(347)
 
 
 
Confirmatory(87)
 
 
 
Literature(28)
 
 
 
 
BioActivity Types:
Potency(70)
 
 
 
IC50(21)
 
 
 
 
EC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 436    Data Row: 472   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103330747]
IC50 4.77Inhibition of lipid peroxidation in Sprague-Dawley rat brain after 30 mins by TBARS assay [AID314540, Type: Literature]
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2
[SID103330747]
IC50 25.7DPPH radical scavenging activity after 180 mins [AID382837, Type: Literature]
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3
[SID103330747]
IC50 28Inhibition of COX2 after 5 mins by spectrophotometric analysis [AID652655, Type: Literature]
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4
[SID103330747]
IC50 39.2Inhibition of COX1 after 5 mins by spectrophotometric analysis [AID652654, Type: Literature]
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5
[SID47193735]
HTS for Identification of VLA-4 Allosteric Modulators from MLPCN library [AID2557, Type: screening]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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6
[SID47193735]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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7
[SID47193735]
Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence [AID686952, Type: screening]
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8
[SID47193735]
Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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9
[SID47193735]
Fluorescence Intensity-based biochemical primary high throughput confirmation assay to identify activators of kallikrein-7 (K7) zymogen [AID686949, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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10
[SID103330747]
IC50 66Antioxidant activity assessed as residual DPPH radical scavenging activity after 45 mins by spectrophotometrically [AID568834, Type: Literature]
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11
[SID103330747]
IC50 100Inhibitory concentration of compound on nitric oxide (NO) production in lipopolysaccharide activated mouse peritoneal macrophages [AID248765, Type: Literature]
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12
[SID103330747]
EC50 250Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometry [AID590194, Type: Literature]
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13
[SID103330747]
IC50 351Inhibition of mushroom tyrosinase after 25 mins by spectrophotometry [AID590195, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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14
[SID103330747]
Antioxidant activity against Cu2+-induced lipid peroxidation in human plasma LDL preincubated for 1 hr before Cu2+ challenge [AID397153, Type: Literature]
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15
[SID103330747]
DPPH radical scavenging activity assessed as Trolox equivalent antioxidant capacity at 50 uM after 40 mins [AID397183, Type: Literature]
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16
[SID103330747]
ABTS radical scavenging activity assessed as Trolox equivalent antioxidant capacity at 50 uM by spectrophotometric analysis [AID397184, Type: Literature]
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17
[SID103330747]
Percent inhibition of nitric oxide (NO) production in lipopolysaccharide activated mouse peritoneal macrophages at 100 uM of compound [AID252044, Type: Literature]
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18
[SID103330747]
Percentage inhibition against release of beta-hexosaminidase from RBL-2H3 cells at 100 uM from control [AID166551, Type: Literature]
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19
[SID103330747]
Inhibitory activity of compound was tested against peroxinitrite in collagen type I at concentration 100 uM of each sample was treated with 1.0 mM peroxynitrite [AID219712, Type: Literature]
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20
[SID103330747]
Inhibitory activity of compound was tested against peroxinitrite in collagen type I with concentration 50 uM of each sample was treated with 1.0 mM peroxynitrite [AID219713, Type: Literature]
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21
[SID103330747]
Antioxidant activity assessed as trolox equivalents of ABTS radical scavenging activity by TEAC assay [AID568835, Type: Literature]
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22
[SID47193735]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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23
[SID103330747]
Effect on human plasma LDL-PLA2 activity by LS-3B fluorescence spectrometry [AID397586, Type: Literature]Platelet-activating factor acetylhydrolase [gi:2497687]
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24
[SID103330747]
Antioxidant activity assessed as DPPH free radical scavenging activity at 0.9 mM after 20 mins [AID342752, Type: Literature]
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25
[SID103330747]
Antioxidant activity assessed as DPPH free radical scavenging activity at 1.8 mM after 10 mins [AID342753, Type: Literature]
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26
[SID103330747]
Antioxidant activity assessed as DPPH free radical scavenging activity at 0.9 mM after 10 mins [AID342754, Type: Literature]
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27
[SID103330747]
Antioxidant activity assessed as DPPH free radical scavenging activity at 1.8 mM after 20 mins [AID342755, Type: Literature]
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28
[SID103330747]
Antioxidant activity assessed as DPPH free radical scavenging activity at 3.6 mM after 10 mins [AID342756, Type: Literature]
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29
[SID103330747]
Antioxidant activity assessed as DPPH free radical scavenging activity at 3.6 mM after 20 mins [AID342757, Type: Literature]
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30
[SID47193735]
Potency 3.9811qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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31
[SID47193735]
Potency 15.8489qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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32
[SID47193735]
Potency 25.1189Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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33
[SID47193735]
Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing System [AID2094, Type: screening]Chain A, Crystal Structure Of The Apo Form Of Vibrio Harveyi Luxp Complexed With The Periplasmic Domain Of Luxq [gi:67463988]
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34
[SID47193735]
Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing System [AID2094, Type: screening]Chain B, Crystal Structure Of The Apo Form Of Vibrio Harveyi Luxp Complexed With The Periplasmic Domain Of Luxq [gi:67463989]
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35
[SID47193735]
Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_SinglePoint_HTS_Activity [AID540336, Type: screening]hypothetical protein CaO19.7491 [Candida albicans SC5314] [gi:68474550]
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36
[SID47193735]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). [AID1962, Type: screening]likely tRNA 2'-phosphotransferase [Candida albicans SC5314] [gi:68476498]
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37
[SID47193735]
Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_SinglePoint_HTS_Activity [AID540336, Type: screening]hypothetical protein CaO19.6625 [Candida albicans SC5314] [gi:68488893]
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38
[SID47193735]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]ras and Rab interactor 1 [Homo sapiens] [gi:68989256]
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39
[SID47193735]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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40
[SID47193735]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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41
[SID47193735]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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42
[SID47193735]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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43
[SID47193735]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN. [AID2029, Type: screening]citrate synthase 2, partial [Saccharomyces cerevisiae] [gi:171229]
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44
[SID47193735]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624268, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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45
[SID47193735]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite S. stercoralis (ssDAF-12) [AID652126, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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46
[SID47193735]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite H. contortus (hcDAF-12) [AID652067, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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47
[SID47193735]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of the DAF-12 from the parasite H. glycines (hgDAF-12). [AID687014, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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48
[SID47193735]
Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of Methionine sulfoxide reductase A (MsrA) [AID651718, Type: screening]MSRA protein [Bos taurus] [gi:73586699]
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49
[SID47193735]
Absorbance-based biochemical primary high throughput screening assay to identify activators of Methionine sulfoxide reductase A (MsrA) [AID602163, Type: screening]MSRA protein [Bos taurus] [gi:73586699]
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50
[SID47193735]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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