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cinnamic aldehyde (CID 637511) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(17)
 
 
Inactive(1002)
 
 
Inconclusive(56)
 
 
Unspecified(165)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
NR LBD ER(29)
 
 
 
 
 
7TM GPCR Srsx(29)
 
 
 
NR LBD PPAR(28)
 
 
 
NR LBD AR(26)
 
 
 
 
 
BioAssay Types:
Confirmatory(629)
 
 
 
 
 
Screening(273)
 
 
 
Literature(107)
 
 
 
 
 
Summary(63)
 
 
 
 
BioActivity Types:
Potency(592)
 
 
 
 
 
IC50(129)
 
 
 
 
EC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 787    Data Row: 1240   Total Pages: 25   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17389103]
Potency 2.5119qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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2
[SID103239041]
EC50 6.5Activation of TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels [AID482140, Type: Literature]
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3
[SID144204695]
Potency-Replicate_1 10.5909qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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4
[SID17389104]
Potency 12.5893qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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5
[SID144204695]
Ratio Potency (uM) 18.9959qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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6
[SID103239041]
EC50 19Activation of TRPA1 [AID329099, Type: Literature]
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7
[SID103239041]
IC50 43Inhibition of NF-kappaB transfected in LPS-stimulated mouse RAW264.7 cells [AID349484, Type: Literature]
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8
[SID144213588]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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9
[SID144213588]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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10
[SID29215112]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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11
[SID29215112]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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12
[SID103239041]
Inhibition of NFATc1 expression in RANKL-stimulated mouse RAW264.7 cells after 48 hrs by immunoblotting [AID349478, Type: Literature]
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13
[SID103239041]
Inhibition of multinucleated cell formation in RANKL-stimulated mouse RAW264.7 cells at 0.5 to 2 uM after 3 days by TRAP staining [AID349479, Type: Literature]
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14
[SID103239041]
Inhibition of bone resorption by mature osteoclast in RANKL-stimulated mouse RAW264.7 cells pretreated for 1 hr measured after 8 days [AID349480, Type: Literature]
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15
[SID17389103]
Cell Viability - NIH 3T3 [AID541, Type: confirmatory]
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16
[SID17389104]
Cell Viability - NIH 3T3 [AID541, Type: confirmatory]
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17
[SID103239041]
Agonist activity at TRPA1 [AID500219, Type: Literature]
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18
[SID103239041]
EC50 51.4Agonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate count [AID452237, Type: Literature]Transient receptor potential cation channel subfamily A member 1 [gi:313104269]
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19
[SID103239041]
IC50 245Inhibition of COX2 [AID403340, Type: Literature]
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20
[SID103239041]
IC50 520Inhibition of mushroom tyrosinase after 10 mins by spectrophotometry [AID467606, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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21
[SID103239041]
IC50 1150Inhibition of beta (1,3) glucan synthase in Candida albicans cell membrane using UDP-Glc as substrate assessed as aniline blue-glucan complex formation by microtiter-based fluorescence method [AID647545, Type: Literature]
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22
[SID103239041]
IC50 DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) [AID625272, Type: other]
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23
[SID17389103]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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24
[SID103239041]
IC50 DRUGMATRIX: Nicotinic Acetylcholine radioligand binding (ligand: [125I] Epibatidine) [AID625158, Type: other]
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25
[SID103239041]
DRUGMATRIX: Phorbol Ester radioligand binding (ligand: [3H] PDBu) [AID625164, Type: other]
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26
[SID103239041]
IC50 DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625165, Type: other]
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27
[SID103239041]
IC50 DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625166, Type: other]
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28
[SID103239041]
DRUGMATRIX: Platelet-Derived Growth Factor (PDGF) radioligand binding (ligand: [125I] PDGF) [AID625169, Type: other]
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29
[SID103239041]
IC50 DRUGMATRIX: Potassium Channel [KATP] radioligand binding (ligand: [3H] Glyburide) [AID625170, Type: other]
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30
[SID103239041]
DRUGMATRIX: Purinergic P2X radioligand binding (ligand: [3H] alpha, beta-Methylene-ATP) [AID625189, Type: other]
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31
[SID103239041]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) [AID625190, Type: other]
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32
[SID103239041]
IC50 DRUGMATRIX: Sodium/nucleoside co-transporter radioligand binding (ligand: nitrobenzylthioinosine) [AID625197, Type: other]
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33
[SID103239041]
IC50 DRUGMATRIX: ATPase, Na+/K+ enzyme inhibition (substrate: ATP) [AID625210, Type: other]
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34
[SID103239041]
DRUGMATRIX: Atrial Natriuretic Factor (ANF) radioligand binding (ligand: [125I] ANF (rat)) [AID625211, Type: other]
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35
[SID103239041]
IC50 DRUGMATRIX: beta-Lactamase enzyme inhibition (substrate: Nitrocefin) [AID625212, Type: other]
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36
[SID103239041]
IC50 DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: other]
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37
[SID103239041]
IC50 DRUGMATRIX: Calcium Channel Type L, Dihydropyridine radioligand binding (ligand: [3H] Nitrendipine) [AID625216, Type: other]
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38
[SID103239041]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT3 radioligand binding (ligand: [3H] GR-65630) [AID625219, Type: other]
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39
[SID103239041]
IC50 DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil) [AID625224, Type: other]
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40
[SID103239041]
IC50 DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
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41
[SID103239041]
DRUGMATRIX: Tumor Necrosis Factor (TNF), Non-Selective radioligand binding (ligand: [125I] TNF-alpha) [AID625230, Type: other]
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42
[SID103239041]
IC50 DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
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43
[SID103239041]
IC50 DRUGMATRIX: GABAA, Muscimol, Central radioligand binding (ligand: [3H] Muscimol) [AID625260, Type: other]
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44
[SID103239041]
IC50 DRUGMATRIX: GABAA, Flunitrazepam, Central radioligand binding (ligand: [3H] Flunitrazepam) [AID625261, Type: other]
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45
[SID103239041]
IC50 DRUGMATRIX: GABAA, Chloride Channel, TBOB radioligand binding (ligand: [3H] TBOB) [AID625262, Type: other]
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46
[SID103239041]
IC50 DRUGMATRIX: Glutamate, AMPA radioligand binding (ligand: [3H] AMPA) [AID625264, Type: other]
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47
[SID103239041]
DRUGMATRIX: Glutamate, Kainate radioligand binding (ligand: [3H] Kainic acid) [AID625265, Type: other]
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48
[SID103239041]
IC50 DRUGMATRIX: Glutamate, NMDA, Agonism radioligand binding (ligand: [3H] CGP-39653) [AID625266, Type: other]
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49
[SID103239041]
IC50 DRUGMATRIX: Glutamate, NMDA, Phencyclidine radioligand binding (ligand: [3H] TCP) [AID625267, Type: other]
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50
[SID103239041]
IC50 DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) [AID625268, Type: other]
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