cinnamic aldehyde (CID 637511) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(12)
 
 
Inactive(723)
 
 
Inconclusive(19)
 
 
Unspecified(165)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(16)
 
 
 
p450(12)
 
 
 
NR LBD TR(10)
 
 
NR LBD PPAR(10)
 
 
 
BioAssay Types:
Confirmatory(417)
 
 
 
 
 
Screening(227)
 
 
 
Literature(107)
 
 
 
 
 
BioActivity Types:
Potency(334)
 
 
 
 
 
IC50(129)
 
 
 
 
EC50(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 664    Data Row: 919   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17389103]
Potency 2.5119qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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2
[SID17389103]
Potency 2.5119qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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3
[SID103239041]
EC50 6.5Activation of TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium levels [AID482140, Type: Literature]
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4
[SID17389104]
Potency 12.5893qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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5
[SID17389104]
Potency 12.5893qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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6
[SID103239041]
EC50 19Activation of TRPA1 [AID329099, Type: Literature]
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7
[SID103239041]
IC50 43Inhibition of NF-kappaB transfected in LPS-stimulated mouse RAW264.7 cells [AID349484, Type: Literature]
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8
[SID17389103]
 Cell Viability - NIH 3T3 [AID541, Type: confirmatory]
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9
[SID17389104]
 Cell Viability - NIH 3T3 [AID541, Type: confirmatory]
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10
[SID103239041]
 Agonist activity at TRPA1 [AID500219, Type: Literature]
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11
[SID103239041]
 Inhibition of NFATc1 expression in RANKL-stimulated mouse RAW264.7 cells after 48 hrs by immunoblotting [AID349478, Type: Literature]
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12
[SID103239041]
 Inhibition of multinucleated cell formation in RANKL-stimulated mouse RAW264.7 cells at 0.5 to 2 uM after 3 days by TRAP staining [AID349479, Type: Literature]
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13
[SID103239041]
 Inhibition of bone resorption by mature osteoclast in RANKL-stimulated mouse RAW264.7 cells pretreated for 1 hr measured after 8 days [AID349480, Type: Literature]
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14
[SID29215112]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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15
[SID103239041]
EC50 51.4Agonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate count [AID452237, Type: Literature]Transient receptor potential cation channel subfamily A member 1 [gi:313104269]
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16
[SID103239041]
EC50 51.4Agonist activity at human TRPA1 expressed in HEK293 cells assessed as [45]Ca2+ influx by microbeta plate count [AID452237, Type: Literature]Transient receptor potential cation channel subfamily A member 1 [gi:313104269]
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17
[SID103239041]
IC50 245Inhibition of COX2 [AID403340, Type: Literature]
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18
[SID103239041]
IC50 520Inhibition of mushroom tyrosinase after 10 mins by spectrophotometry [AID467606, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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19
[SID103239041]
IC50 1150Inhibition of beta (1,3) glucan synthase in Candida albicans cell membrane using UDP-Glc as substrate assessed as aniline blue-glucan complex formation by microtiter-based fluorescence method [AID647545, Type: Literature]
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20
[SID103239041]
IC50 DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) [AID625272, Type: other]
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21
[SID17389103]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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22
[SID103239041]
 Induction of neurogenic inflammation in rat esophagus assessed as CGRP release per 20 mins at 50 uM [AID386014, Type: Literature]
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23
[SID103239041]
 Induction of neurogenic inflammation in capsaicin desensitized rat esophagus assessed as substance P release per 20 mins at 50 uM [AID386013, Type: Literature]
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24
[SID103239041]
 Induction of neurogenic inflammation in rat dorsal spinal cord assessed as CGRP release per 20 mins at 10 uM in calcium free medium [AID385779, Type: Literature]
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25
[SID17389104]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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26
[SID103239041]
 Inhibition of xanthine oxidase- mediated uric acid formation at 50 ug/mL after 5 mins by spectrophotometry [AID670363, Type: Literature]
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27
[SID103239041]
 Inhibition of xanthine oxidase- mediated uric acid formation after 5 mins by spectrophotometry [AID670364, Type: Literature]
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28
[SID103239041]
IC50 DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: other]Progesterone receptor [gi:75071465]
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29
[SID103239041]
IC50 DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) [AID625144, Type: other]Leukotriene C4 synthase [gi:239977155]
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30
[SID103239041]
IC50 DRUGMATRIX: Angiotensin AT2 radioligand binding (ligand: [125I] CGP-42112A) [AID625209, Type: other]Type-2 angiotensin II receptor [gi:1703214]
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31
[SID103239041]
IC50 DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: other]Adenosine receptor A [gi:231473]
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32
[SID103239041]
IC50 DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: other]Adenosine receptor A [gi:231473]
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33
[SID103239041]
IC50 DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: other]Adenosine receptor A [gi:231473]
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34
[SID103239041]
IC50 DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) [AID625195, Type: other]Adenosine receptor A2 [gi:543740]
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35
[SID103239041]
IC50 DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) [AID625195, Type: other]Adenosine receptor A2 [gi:543740]
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36
[SID103239041]
IC50 DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) [AID625195, Type: other]Adenosine receptor A2 [gi:543740]
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37
[SID103239041]
IC50 DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: other]Adenosine receptor A [gi:1351831]
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38
[SID103239041]
IC50 DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: other]Adenosine receptor A [gi:1351831]
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39
[SID103239041]
IC50 DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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40
[SID103239041]
IC50 DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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41
[SID103239041]
IC50 DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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42
[SID103239041]
IC50 DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: other]Alpha-2A adrenergic receptor [gi:1351829]
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43
[SID103239041]
IC50 DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: other]Alpha-2A adrenergic receptor [gi:1351829]
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44
[SID103239041]
IC50 DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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45
[SID103239041]
IC50 DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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46
[SID103239041]
IC50 DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: other]Alpha-2C adrenergic receptor [gi:20141211]
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47
[SID103239041]
IC50 DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: other]Alpha-2C adrenergic receptor [gi:20141211]
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48
[SID103239041]
IC50 DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) [AID625204, Type: other]Beta-1 adrenergic receptor [gi:48429211]
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49
[SID103239041]
IC50 DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) [AID625204, Type: other]Beta-1 adrenergic receptor [gi:48429211]
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50
[SID103239041]
IC50 DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) [AID625204, Type: other]Beta-1 adrenergic receptor [gi:48429211]
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