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Arginine (CID 6322) - Compound BioActivity Data
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BioActivity Outcomes:
Active(21)
 
 
Inactive(375)
 
 
Inconclusive(29)
 
 
Unspecified(65)
 
 
Top Targets:
p450(14)
 
 
 
 
NR LBD ER(8)
 
 
NR LBD PPAR(8)
 
 
 
NR LBD GR(8)
 
 
NOS oxygenase..(7)
 
 
 
BioAssay Types:
Confirmatory(343)
 
 
 
 
 
Literature(87)
 
 
 
 
 
Summary(25)
 
 
Screening(14)
 
 
BioActivity Types:
Potency(318)
 
 
 
 
Kd(3)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 396    Data Row: 490   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103549060]
Km 0.9Tested for the inhibition of human Endothelial nitric oxide synthase [AID68158, Type: other]
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2
[SID103549060]
Km 1.1Activity of bovine eNOS by Michaelis-Menten equation analysis [AID620028, Type: Literature]Nitric oxide synthase, endothelial [gi:266647]
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3
[SID103549060]
Km 1.6Tested for the inhibition of human neuronal tissue Neuronal nitric oxide synthase [AID146135, Type: other]
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4
[SID103549060]
Km 2.2Tested for the inhibition of human Inducible nitric oxide synthase [AID92146, Type: other]
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5
[SID103549060]
Km 2.7Activity of rat nNOS by Michaelis-Menten equation analysis [AID620024, Type: Literature]Nitric oxide synthase, brain [gi:266646]
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6
[SID103549060]
Km 2.8Activity of human recombinant iNOS expressed in Escherichia coli [AID362522, Type: Literature]Nitric oxide synthase, inducible [gi:1352513]
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7
[SID103549060]
Kd 7Binding affinity to iNOS with heme domain construct assessed as spectral binding constant by spectral assay [AID415946, Type: Literature]
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8
[SID103549060]
Kd 7Binding affinity to truncated iNOS construct (1-490) by spectral assay [AID321793, Type: Literature]
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9
[SID103549060]
Km 8.6Activity of iNOS assessed as oxidation of oxyhemoglobin to methemoglobin by indirect spectral assay [AID415945, Type: Literature]
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10
[SID103549060]
Km 9.5Activity of mouse iNOS by Michaelis-Menten equation analysis [AID620026, Type: Literature]Nitric oxide synthase, inducible [gi:266649]
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11
[SID103549060]
Decrease in ARG5,6 mRNA level in Saccharomyces cerevisiae BY4741 at 1 mg/ml by northern blot analysis relative to control [AID590839, Type: Literature]
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12
[SID103549060]
Decrease in CPA1 mRNA level in Saccharomyces cerevisiae BY4741 at 1 mg/ml by northern blot analysis relative to control [AID590840, Type: Literature]
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13
[SID46392409]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain E, Structural Bases For Multiple Ligand Specificity Of The Periplasmic Lysine-, Arginine-, Ornithine-binding Protein [gi:1065303]
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14
[SID103549060]
Decrease in TAP-tagged ARG5,6 protein level in Saccharomyces cerevisiae YSC1178-7500224 at 1 mg/ml by Western blotting analysis relative to control [AID590842, Type: Literature]
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15
[SID103549060]
Decrease in TAP-tagged CPA1 protein level in Saccharomyces cerevisiae YSC1178-7502950 at 1 mg/ml by Western blotting analysis relative to control [AID590843, Type: Literature]
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16
[SID103549060]
NO releasing ability of compound measured through formation of nitrite using inducible nitric oxide synthase [AID92307, Type: Literature]
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17
[SID103549060]
NO releasing ability of compound measured through formation of nitrite using neuronal nitric oxide synthase [AID146287, Type: Literature]
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18
[SID103549060]
Increase in DAF2 monitored NO production in BAEC at 10 mM after 30 mins [AID269128, Type: Literature]
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19
[SID11110746]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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20
[SID11110746]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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21
[SID11113629]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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22
[SID103549060]
Kd 60Dissociation constant of the compound [AID238114, Type: Literature]
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23
[SID103549060]
Area under DAF2 monitored nitrite production in GH3 cells-incubation period curve [AID269127, Type: Literature]
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24
[SID103549060]
Partition coefficient (logP) [AID26797, Type: Literature]
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25
[SID103549060]
Inhibition of alpha-dicarbonyls-induced advanced glycation endproduct formation assessed as protection against 50 eq. MG-induced insulin degradation at 3.75 mM after 24 hrs by RP-HPLC [AID450158, Type: Literature]
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26
[SID103549060]
Cytotoxicity against cat CRFK cells by MTS assay [AID539926, Type: Literature]
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27
[SID103549060]
Antiviral activity against Feline coronavirus FIPV infected in cat CRFK cells assessed as protection against virus-induced cytopathogenicity after 2 days by MTS assay [AID539927, Type: Literature]
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28
[SID103549060]
Antiviral activity against Feline herpes virus infected in cat CRFK cells assessed as protection against virus-induced cytopathogenicity after 2 days by MTS assay [AID539928, Type: Literature]
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29
[SID103549060]
Toxicity in patient with severe malaria assessed as pain at drug infusion site at 3 to 12 g, iv for 30 mins via infusion pump [AID580448, Type: Literature]
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30
[SID103549060]
Toxicity in patient with severe malaria assessed as inflammation at 3 to 12 g, iv for 30 mins via infusion pump [AID580449, Type: Literature]
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31
[SID103549060]
Toxicity in patient with severe malaria assessed as effect on pulse rate at 3 to 12 g, iv for 30 mins via infusion pump measured during drug infusion [AID580450, Type: Literature]
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32
[SID103549060]
Toxicity in patient with severe malaria assessed as effect on pulse rate at 3 to 12 g, iv for 30 mins via infusion pump measured after drug infusion [AID580451, Type: Literature]
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33
[SID103549060]
Toxicity in patient with severe malaria assessed as effect on respiratory rate at 3 to 12 g, iv for 30 mins via infusion pump measured during drug infusion [AID580452, Type: Literature]
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34
[SID103549060]
Toxicity in patient with severe malaria assessed as effect on respiratory rate at 3 to 12 g, iv for 30 mins via infusion pump measured after drug infusion [AID580453, Type: Literature]
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35
[SID103549060]
Toxicity in patient with severe malaria assessed as decrease of systolic blood pressure at 3 to 6 g, iv for 30 mins via infusion pump [AID580454, Type: Literature]
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36
[SID103549060]
Toxicity in patient with severe malaria assessed as decrease of diastolic blood pressure at 3 to 6 g, iv for 30 mins via infusion pump [AID580455, Type: Literature]
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37
[SID103549060]
Toxicity in patient with severe malaria assessed as decrease of systolic blood pressure at 12 g, iv for 30 mins via infusion pump [AID580456, Type: Literature]
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38
[SID103549060]
Toxicity in patient with severe malaria assessed as decrease of diastolic blood pressure at 12 g, iv for 30 mins via infusion pump [AID580457, Type: Literature]
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39
[SID103549060]
Plasma concentration in patient with severe malaria at 3 g, iv for 30 mins via infusion pump [AID580458, Type: Literature]
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40
[SID103549060]
Plasma concentration in patient with severe malaria at 6 g, iv for 30 mins via infusion pump [AID580459, Type: Literature]
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41
[SID103549060]
Plasma concentration in patient with severe malaria at 12 g, iv for 30 mins via infusion pump [AID580460, Type: Literature]
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42
[SID103549060]
Primary phase half life in patient with severe malaria administered as iv for 30 mins via infusion pump [AID580461, Type: Literature]
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43
[SID103549060]
Terminal half life in patient with severe malaria administered as iv for 30 mins via infusion pump [AID580462, Type: Literature]
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44
[SID103549060]
Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
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45
[SID103549060]
Human drug-induced liver injury (DILI) modelling dataset from Ekins et al [AID588210, Type: Literature]
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46
[SID103549060]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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47
[SID103549060]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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48
[SID103549060]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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49
[SID103549060]
Permeability across GH3 cell membrane [AID269129, Type: Literature]
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50
[SID103549060]
Antinociceptive effect in mouse assessed as number of writhes for 10 mins at 50 mg/kg, ip [AID307228, Type: Literature]
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