Arginine (CID 6322) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(21)
 
 
Inactive(262)
 
 
Inconclusive(26)
 
 
Unspecified(65)
 
 
Top Targets:
p450(13)
 
 
 
 
 
NOS oxygenase..(7)
 
 
 
PLN02808(7)
 
 
 
Tubulin-bindi..(6)
 
 
 
HELICc(6)
 
 
BioAssay Types:
Confirmatory(254)
 
 
 
 
 
Literature(85)
 
 
 
 
 
Screening(13)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(213)
 
 
 
 
Kd(3)
 
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 299    Data Row: 374   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103549060]
Km 0.9Tested for the inhibition of human Endothelial nitric oxide synthase [AID68158, Type: other]
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2
[SID103549060]
Km 1.1Activity of bovine eNOS by Michaelis-Menten equation analysis [AID620028, Type: Literature]Nitric oxide synthase, endothelial [gi:266647]
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3
[SID103549060]
Km 1.6Tested for the inhibition of human neuronal tissue Neuronal nitric oxide synthase [AID146135, Type: other]
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4
[SID103549060]
Km 2.2Tested for the inhibition of human Inducible nitric oxide synthase [AID92146, Type: other]
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5
[SID103549060]
Km 2.7Activity of rat nNOS by Michaelis-Menten equation analysis [AID620024, Type: Literature]Nitric oxide synthase, brain [gi:266646]
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6
[SID103549060]
Km 2.8Activity of human recombinant iNOS expressed in Escherichia coli [AID362522, Type: Literature]Nitric oxide synthase, inducible [gi:1352513]
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7
[SID103549060]
Kd 7Binding affinity to truncated iNOS construct (1-490) by spectral assay [AID321793, Type: Literature]
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8
[SID103549060]
Kd 7Binding affinity to iNOS with heme domain construct assessed as spectral binding constant by spectral assay [AID415946, Type: Literature]
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9
[SID103549060]
Km 8.6Activity of iNOS assessed as oxidation of oxyhemoglobin to methemoglobin by indirect spectral assay [AID415945, Type: Literature]
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10
[SID103549060]
Km 9.5Activity of mouse iNOS by Michaelis-Menten equation analysis [AID620026, Type: Literature]Nitric oxide synthase, inducible [gi:266649]
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11
[SID103549060]
 Decrease in TAP-tagged ARG5,6 protein level in Saccharomyces cerevisiae YSC1178-7500224 at 1 mg/ml by Western blotting analysis relative to control [AID590842, Type: Literature]
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12
[SID103549060]
 Decrease in TAP-tagged CPA1 protein level in Saccharomyces cerevisiae YSC1178-7502950 at 1 mg/ml by Western blotting analysis relative to control [AID590843, Type: Literature]
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13
[SID103549060]
 Increase in DAF2 monitored NO production in BAEC at 10 mM after 30 mins [AID269128, Type: Literature]
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14
[SID103549060]
 NO releasing ability of compound measured through formation of nitrite using inducible nitric oxide synthase [AID92307, Type: Literature]
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15
[SID103549060]
 NO releasing ability of compound measured through formation of nitrite using neuronal nitric oxide synthase [AID146287, Type: Literature]
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16
[SID11110746]
 qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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17
[SID11110746]
 qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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18
[SID103549060]
 Decrease in ARG5,6 mRNA level in Saccharomyces cerevisiae BY4741 at 1 mg/ml by northern blot analysis relative to control [AID590839, Type: Literature]
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19
[SID103549060]
 Decrease in CPA1 mRNA level in Saccharomyces cerevisiae BY4741 at 1 mg/ml by northern blot analysis relative to control [AID590840, Type: Literature]
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20
[SID46392409]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain E, Structural Bases For Multiple Ligand Specificity Of The Periplasmic Lysine-, Arginine-, Orn [gi:1065303]
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21
[SID11113629]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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22
[SID11113629]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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23
[SID11113629]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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24
[SID103549060]
Kd 60Dissociation constant of the compound [AID238114, Type: Literature]
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25
[SID103549060]
 Evaluation as substrate of Neuronal nitric oxide synthase by hemoglobin assay using NOHA as control [AID146280, Type: Literature]
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26
[SID103549060]
 Cleavage rate against hairpin ribozyme at 2 mM, in presence of 0.5 uM magnesium ions [AID198301, Type: Literature]
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27
[SID103549060]
 Cleavage rate against hairpin ribozyme at 5 mM with 0.5 uM magnesium ions [AID198302, Type: Literature]
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28
[SID103549060]
 NO-releasing ability under the oxidation by horseradish peroxidase (HRP) in the presence of H2O2 for 20min, expressed as nitrite concentration [AID228484, Type: Literature]
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29
[SID103549060]
 Bitter threshold value [AID233318, Type: Literature]
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30
[SID103549060]
 In vivo blood glucose was determined in obese, hyperglycemic, hyperinsulinemic, insulin-resistant KKAy mice after a dose of 500 mg/kg for 4 days [AID94678, Type: Literature]
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31
[SID103549060]
 Evaluation as substrate of Inducible nitric oxide synthase by hemoglobin assay using NOHA as control [AID92180, Type: Literature]
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32
[SID103549060]
 Evaluation as substrate of endothelial nitric oxide synthase by hemoglobin assay using NOHA as control [AID68159, Type: Literature]
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33
[SID103549060]
 Permeability across GH3 cell membrane [AID269129, Type: Literature]
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34
[SID103549060]
 Antinociceptive effect in mouse assessed as number of writhes for 10 mins at 50 mg/kg, ip [AID307228, Type: Literature]
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35
[SID103549060]
 Protection against hepatic ischemia-reperfusion-induced injury assessed as effect on malondialdehyde level in Wistar rat liver at 30 mg/kg [AID315046, Type: Literature]
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36
[SID103549060]
 Protection against hepatic ischemia-reperfusion-induced injury assessed as effect on aspartate aminotransferase level in Wistar rat liver at 30 mg/kg [AID315047, Type: Literature]
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37
[SID103549060]
 Protection against hepatic ischemia-reperfusion-induced injury assessed as effect on alanine aminotransferase level in Wistar rat liver at 30 mg/kg [AID315048, Type: Literature]
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38
[SID103549060]
 Partition coefficient (logP) [AID26797, Type: Literature]
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39
[SID103549060]
 Area under DAF2 monitored nitrite production in GH3 cells-incubation period curve [AID269127, Type: Literature]
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40
[SID103549060]
 Cytotoxicity against cat CRFK cells by MTS assay [AID539926, Type: Literature]
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41
[SID103549060]
 Antiviral activity against Feline coronavirus FIPV infected in cat CRFK cells assessed as protection against virus-induced cytopathogenicity after 2 days by MTS assay [AID539927, Type: Literature]
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42
[SID103549060]
 Antiviral activity against Feline herpes virus infected in cat CRFK cells assessed as protection against virus-induced cytopathogenicity after 2 days by MTS assay [AID539928, Type: Literature]
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43
[SID103549060]
 Toxicity in patient with severe malaria assessed as pain at drug infusion site at 3 to 12 g, iv for 30 mins via infusion pump [AID580448, Type: Literature]
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44
[SID103549060]
 Toxicity in patient with severe malaria assessed as inflammation at 3 to 12 g, iv for 30 mins via infusion pump [AID580449, Type: Literature]
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45
[SID103549060]
 Toxicity in patient with severe malaria assessed as effect on pulse rate at 3 to 12 g, iv for 30 mins via infusion pump measured during drug infusion [AID580450, Type: Literature]
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46
[SID103549060]
 Toxicity in patient with severe malaria assessed as effect on pulse rate at 3 to 12 g, iv for 30 mins via infusion pump measured after drug infusion [AID580451, Type: Literature]
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47
[SID103549060]
 Toxicity in patient with severe malaria assessed as effect on respiratory rate at 3 to 12 g, iv for 30 mins via infusion pump measured during drug infusion [AID580452, Type: Literature]
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48
[SID103549060]
 Toxicity in patient with severe malaria assessed as effect on respiratory rate at 3 to 12 g, iv for 30 mins via infusion pump measured after drug infusion [AID580453, Type: Literature]
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49
[SID103549060]
 Toxicity in patient with severe malaria assessed as decrease of systolic blood pressure at 3 to 6 g, iv for 30 mins via infusion pump [AID580454, Type: Literature]
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50
[SID103549060]
 Toxicity in patient with severe malaria assessed as decrease of diastolic blood pressure at 3 to 6 g, iv for 30 mins via infusion pump [AID580455, Type: Literature]
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