Buprenorphine (CID 6321408) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(32)
 
 
Inactive(7)
 
 
Inconclusive(18)
 
 
Unspecified(82)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
 
 
GT1 Gtf like(10)
 
 
 
7TM GPCR Srv(1)
 
 
NAD binding 8(1)
 
 
BioAssay Types:
Literature(137)
 
 
 
 
 
BioActivity Types:
IC50(23)
 
 
 
Ki(16)
 
 
EC50(12)
 
 
 
 
 
Kd(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 139    Data Row: 139   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234389]
EC50 0.00011Activity at human cloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID410728, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
2
[SID104234389]
EC50 0.00011Activity at human cloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID410728, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
3
[SID104234389]
EC50 0.00011Activity at human cloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID410728, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
4
[SID104234389]
EC50 0.00011Activity at human cloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID410728, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
5
[SID104234389]
EC50 0.00018Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID410731, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
6
[SID104234389]
EC50 0.00018Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID410731, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
7
[SID104234389]
EC50 0.00018Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID410731, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
8
[SID104234389]
EC50 0.00018Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID410731, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
9
[SID104234389]
Ki 0.00021Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells [AID410718, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
10
[SID104234389]
Ki 0.00021Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells [AID410718, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
11
[SID104234389]
Ki 0.00021Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells [AID410718, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
12
[SID104234389]
Ki 0.00021Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells [AID410718, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
13
[SID104234389]
IC50 0.00041Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl [AID226060, Type: Literature]
View
14
[SID104234389]
IC50 0.00044Inhibition of [3H]naloxone binding to rat brain membrane with 100 mM NaCl. [AID226059, Type: Literature]
View
15
[SID104234389]
IC50 0.00059Activity at human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding [AID410730, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
16
[SID104234389]
IC50 0.00059Activity at human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding [AID410730, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
17
[SID104234389]
IC50 0.00059Activity at human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding [AID410730, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
18
[SID104234389]
IC50 0.00059Activity at human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding [AID410730, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
19
[SID104234389]
Ki 0.00062Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells [AID410720, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
20
[SID104234389]
Ki 0.00062Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells [AID410720, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
21
[SID104234389]
Ki 0.00062Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells [AID410720, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
22
[SID104234389]
Ki 0.00062Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells [AID410720, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
23
[SID104234389]
Ki 0.0008Displacement of [3H]U-69593 from human cloned kappa opioid receptor [AID298632, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
24
[SID104234389]
Ki 0.0008Displacement of [3H]U-69593 from human cloned kappa opioid receptor [AID298632, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
25
[SID104234389]
Ki 0.0008Displacement of [3H]U-69593 from human cloned kappa opioid receptor [AID298632, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
26
[SID104234389]
Ki 0.0008Displacement of [3H]U-69593 from human cloned kappa opioid receptor [AID298632, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
27
[SID104234389]
Ki 0.0008Binding affinity to cloned human Opioid receptor kappa 1 transfected into hamster ovary cells using [3H]U-69593 as a radioligand. [AID148008, Type: Literature]
View
28
[SID104234389]
Ki 0.0013Binding affinity towards mu opioid receptor in guinea pig brain membranes using [3H]- DAMGO as radioligand [AID224557, Type: Literature]Mu-type opioid receptor [gi:3024265]
View
29
[SID104234389]
Ki 0.0015Binding affinity towards kappa opioid receptor in guinea pig brain membranes using [3H]- U-69,593 as radioligand [AID223576, Type: Literature]Kappa-type opioid receptor [gi:730228]
View
30
[SID104234389]
Ki 0.0015Displacement of [3H]DAMGO from human cloned mu opioid receptor [AID298631, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
31
[SID104234389]
Ki 0.0015Displacement of [3H]DAMGO from human cloned mu opioid receptor [AID298631, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
32
[SID104234389]
Ki 0.0015Displacement of [3H]DAMGO from human cloned mu opioid receptor [AID298631, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
33
[SID104234389]
Ki 0.0015Displacement of [3H]DAMGO from human cloned mu opioid receptor [AID298631, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
34
[SID104234389]
Ki 0.0015Binding affinity to cloned human Opioid receptor mu 1 transfected into hamster ovary cells using [3H]DAMGO as a radioligand. [AID150977, Type: Literature]
View
35
[SID104234389]
Ki 0.0015Displacement of [3H]DAMGO from human MOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621887, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
36
[SID104234389]
Ki 0.0015Displacement of [3H]DAMGO from human MOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621887, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
37
[SID104234389]
Ki 0.0015Displacement of [3H]DAMGO from human MOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621887, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
38
[SID104234389]
Ki 0.0015Displacement of [3H]DAMGO from human MOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621887, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
39
[SID104234389]
Ki 0.0016Binding affinity towards delta opioid receptor in guinea pig brain membranes using [3H]- CI-DPDPE as radioligand [AID220389, Type: Literature]
View
40
[SID104234389]
EC50 0.0023GTPgammaS binding in cloned human Opioid receptor mu 1 transfected into hamster ovary cells [AID148340, Type: Literature]
View
41
[SID104234389]
EC50 0.0023Activity was evaluated in human mu opioid receptors transfected with CHO cells by [35S]GTP-gamma-S, assay [AID224558, Type: Literature]
View
42
[SID104234389]
Ki 0.0025Displacement of [3H]U69593 from human KOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621889, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
43
[SID104234389]
Ki 0.0025Displacement of [3H]U69593 from human KOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621889, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
44
[SID104234389]
Ki 0.0025Displacement of [3H]U69593 from human KOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621889, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
45
[SID104234389]
Ki 0.0025Displacement of [3H]U69593 from human KOP receptor expressed in CHO cells after 60 mins by scintillation counting [AID621889, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
46
[SID104234389]
Ki 0.0029Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells [AID410719, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
47
[SID104234389]
Ki 0.0029Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells [AID410719, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
48
[SID104234389]
Ki 0.0045Displacement of [3H]DPDPE from human cloned delta opioid receptor [AID298633, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
49
[SID104234389]
Ki 0.0045Displacement of [3H]DPDPE from human cloned delta opioid receptor [AID298633, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
50
[SID104234389]
Ki 0.0045Binding affinity to cloned human Opioid receptor delta 1 transfected into hamster ovary cells using [3H]DPDPE as a radioligand. [AID148238, Type: Literature]
View