Tryptophan (CID 6305) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(82)
 
 
Inactive(389)
 
 
Inconclusive(58)
 
 
Unspecified(86)
 
 
Top Targets:
alpha CA I II..(26)
 
 
 
7TM GPCR Srx(12)
 
 
p450(10)
 
 
 
Pyruvate Kina..(8)
 
 
PLN02808(7)
 
 
BioAssay Types:
Confirmatory(276)
 
 
 
 
 
Literature(153)
 
 
 
 
Screening(118)
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(222)
 
 
 
 
 
IC50(36)
 
 
 
 
EC50(6)
 
 
Ki(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 567    Data Row: 615   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103241616]
Km 0.83Activity at Aspergilus fumigatus CdpNPT by HPLC analysis [AID422797, Type: Literature]
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2
[SID103241616]
IC50 3.5Antioxidant activity assessed as inhibition of HOCl-induced oxidation of DHR by rhodamine 123 staining [AID537676, Type: Literature]
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3
[SID90341602]
Potency 8.4368qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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4
[SID50107108]
Potency 11.2202qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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5
[SID103241616]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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6
[SID103241616]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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7
[SID103241616]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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8
[SID103241616]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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9
[SID26732620]
Potency 14.1254qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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10
[SID103241616]
IC50 19.2Antioxidant activity assessed as inhibition of peroxynitrite anion-induced oxidation of non-fluorescent DHR by rhodamine 123 staining in presence of NaHCO3 [AID537680, Type: Literature]
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11
[SID103241616]
IC50 31.9Antioxidant activity assessed as inhibition of peroxynitrite anion-induced oxidation of non-fluorescent DHR by rhodamine 123 staining in absence of NaHCO3 [AID537679, Type: Literature]
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12
[SID26732620]
Potency 50.1187qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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13
[SID103241616]
 Activation of of human recombinant CA14 by CO2 hydrase assay [AID291067, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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14
[SID103241616]
 Activation of human recombinant CA14 after 15 mins by stopped-flow CO2 hydration assay [AID387539, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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15
[SID103241616]
 Activation of human recombinant CA5B after 15 mins by stopped-flow CO2 hydration assay [AID387533, Type: Literature]Carbonic anhydrase 5B, mitochondrial [gi:8928041]
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16
[SID103241616]
 Activation of human recombinant carbonic anhydrase 5B by stopped-flow CO2 hydrase method [AID305777, Type: Literature]Carbonic anhydrase 5B, mitochondrial [gi:8928041]
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17
[SID103241616]
 Activation of mouse recombinant CA13 after 15 mins by stopped-flow CO2 hydration assay [AID387538, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
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18
[SID103241616]
 Activation of mouse recombinant CA13 by CO2 hydrase method [AID268622, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
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19
[SID103241616]
 Activation of membrane associated mouse recombinant carbonic anhydrase 15 isoform by stopped-flow CO2 hydrase method [AID375787, Type: Literature]Carbonic anhydrase 15 [gi:30580362]
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20
[SID46392975]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Regulatory Features Of The Trp Operon And The Crystal Structure Of The Trp Rna-Binding Atte [gi:4930086]
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21
[SID103241616]
 Activation of Candida glabrata recombinant carbonic anhydrase by stopped flow CO2 hydration method [AID464322, Type: Literature]Similar to sp|P53615 Saccharomyces cerevisiae YNL036w NCE3 [gi:74610182]
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22
[SID103241616]
 Activation of Candida albicans beta-carbonic anhydrase Nce103 by stopped flow CO2 hydration assay [AID458784, Type: Literature]Hypothetical protein NCE103 [gi:74656605]
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23
[SID46393776]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain C, Structure Of Trprs Ii Bound To Atp [gi:73536118]
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24
[SID103241616]
 Binding affinity to amyloid beta (1 to 42) fibrils by change in fluorescence at 100 uM after 10 mins [AID475504, Type: Literature]
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25
[SID103241616]
 Binding affinity to amyloid beta (1 to 42) oligomers by change in fluorescence at 100 uM after 10 mins [AID475505, Type: Literature]
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26
[SID103241616]
 Activation of Stylophora pistillata carbonic anhydrase STPCA by stopped flow CO2 hydration assay [AID462832, Type: Literature]
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27
[SID103241616]
 Activation of archaea Methanobacterium thermoautotrophicum recombinant carbonic anhydrase by stopped flow CO2 hydration method [AID464320, Type: Literature]
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28
[SID103241616]
 Activation of human recombinant CA1 by stopped-flow CO2 hydrase assay [AID409984, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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29
[SID103241616]
 Activation of human recombinant CA1 at 10 uM by stopped-flow CO2 hydration method [AID365827, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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30
[SID103241616]
 Activation of human recombinant CA1 after 15 mins by stopped-flow CO2 hydration assay [AID387526, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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31
[SID103241616]
 Activation of human recombinant CA1 by CO2 hydrase assay [AID268620, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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32
[SID103241616]
 Activation of human recombinant CA1 by CO2 hydrase assay [AID291061, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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33
[SID103241616]
 Activation of human recombinant CA1 by stopped flow CO2 hydrase method [AID307896, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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34
[SID103241616]
 Activation of human recombinant CA1 by stopped-flow CO2 hydration method [AID318343, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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35
[SID103241616]
 Activation of human recombinant CA1 by stopped flow CO2 hydration assay [AID462829, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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36
[SID103241616]
 Activation of human recombinant CA2by stopped flow CO2 hydration assay [AID462830, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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37
[SID103241616]
 Activation of human recombinant carbonic anhydrase isoenzyme 2 by stopped flow CO2 hydration method [AID464319, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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38
[SID103241616]
 Activation of human recombinant CA2 by stopped-flow CO2 hydration method [AID318344, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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39
[SID103241616]
 Activation of human recombinant CA2 by stopped flow CO2 hydrase method [AID307897, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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40
[SID103241616]
 Activation of human recombinant CA2 by CO2 hydrase assay [AID291063, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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41
[SID103241616]
 Activation of human recombinant CA2 by CO2 hydrase assay [AID268621, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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42
[SID103241616]
 Activation of human recombinant CA2 after 15 mins by stopped-flow CO2 hydration assay [AID387527, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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43
[SID103241616]
 Activation of human recombinant CA2 after 24 hrs by stopped-flow CO2 hydration assay [AID387528, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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44
[SID103241616]
 Activation of human recombinant CA2 at 10 uM by stopped-flow CO2 hydration method [AID365828, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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45
[SID103241616]
 Activation of human recombinant CA2 by stopped-flow CO2 hydrase assay [AID409986, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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46
[SID103241616]
 Activation of human recombinant CA2 by stopped-flow CO2 hydrase method [AID414329, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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47
[SID103241616]
 Activation of human recombinant CA3 by stopped-flow CO2 hydrase assay [AID409993, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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48
[SID103241616]
 Activation of human recombinant CA3 at 10 uM by stopped-flow CO2 hydration method [AID365829, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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49
[SID103241616]
 Activation of human recombinant CA3 after 15 mins by stopped-flow CO2 hydration assay [AID387530, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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50
[SID103241616]
 Activation of human recombinant truncated CA4 at 10 uM by stopped-flow CO2 hydration method [AID365830, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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