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Valine (CID 6287) - Compound BioActivity Data
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BioActivity Outcomes:
Active(31)
 
 
Inactive(4)
 
 
Inconclusive(3)
 
 
Unspecified(14)
 
 
Top Targets:
MFS(5)
 
 
 
 
Arginase-like(3)
 
 
BioAssay Types:
Literature(52)
 
 
 
 
 
BioActivity Types:
Ki(3)
 
 
 
EC50(2)
 
 
 
IC50(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 51    Data Row: 52   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID46393202]
Ki 3600Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Arginase-L-Valine Complex [gi:56553820]
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2
[SID46393202]
Ki 3600Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Arginase-L-Valine Complex [gi:56553820]
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3
[SID46393202]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Arginase-L-Valine Complex [gi:56553820]
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4
[SID103224325]
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha secretion at 1.5 to 4.5 uM after 12 hrs by ELISA [AID722330, Type: Literature]
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5
[SID103224325]
Drug uptake in human RBC assessed as membrane localization at 9 uM after 10 to 30 mins by confocal microscopic analysis [AID722331, Type: Literature]
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6
[SID103224325]
Binding affinity to FITC-tagged LPS assessed as induction of disintegration up to 40 uM by circular dichroism analysis [AID722294, Type: Literature]
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7
[SID103224325]
Binding affinity to LPS assessed as increase in helical structure at 36 uM by circular dichroism analysis [AID722295, Type: Literature]
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8
[SID103224325]
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL6 secretion at 1.5 to 4.5 uM after 12 hrs by ELISA [AID722296, Type: Literature]
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9
[SID103224325]
Antiinflammatory activity in mouse RAW264.7 cells assessed as downregulation of LPS-induced iNOS2 expression at 4.5 uM after 24 hrs by Western blotting analysis [AID722297, Type: Literature]
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10
[SID103224325]
Antiinflammatory activity in mouse RAW264.7 cells assessed as downregulation of LPS-induced TNFalpha expression at 4.5 uM after 24 hrs by Western blotting analysis [AID722298, Type: Literature]
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11
[SID103224325]
Binding affinity to PE/PG lipid vesicles assessed as increase in helical structure at 36 uM by circular dichroism analysis [AID722302, Type: Literature]
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12
[SID103224325]
Binding affinity to PE/PG lipid vesicles assessed as decrease in decrease in acrylamide-induced tryptophan fluorescence quenching at 1 uM [AID722304, Type: Literature]
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13
[SID103224325]
Binding affinity to PE/PG lipid vesicles assessed as induction of large blue shift at 1 uM by fluorescence assay [AID722307, Type: Literature]
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14
[SID103224325]
Induction of dissipation of diffusion potential in PC/Chol lipid vesicles by fluorescence assay [AID722308, Type: Literature]
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15
[SID103224325]
Induction of dissipation of diffusion potential in PE/PG lipid vesicles by fluorescence assay [AID722309, Type: Literature]
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16
[SID103224325]
Bactericidal activity against Staphylococcus aureus ATCC 9144 assessed as induction of membrane depolarization at up to 7 uM by DiSC3(5) staining-based fluorescence assay [AID722310, Type: Literature]
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17
[SID103224325]
Bactericidal activity against Escherichia coli ATCC 10536 assessed as induction of membrane damage at 5 uM after 30 mins by propidium iodide staining-based flow cytometric analysis [AID722312, Type: Literature]
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18
[SID103224325]
Drug uptake in Escherichia coli ATCC 10536 assessed as membrane localization at 3 uM after 30 mins by confocal microscopic analysis [AID722314, Type: Literature]
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19
[SID103224325]
Antifungal activity against Aspergillus fumigatus after 72 hrs by NCCLS microbroth dilution method [AID722315, Type: Literature]
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20
[SID103224325]
Antifungal activity against Trichophyton mentagrophytes after 96 hrs by NCCLS microbroth dilution method [AID722316, Type: Literature]
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