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Valine (CID 6287) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(29)
 
 
Inactive(4)
 
 
Inconclusive(3)
 
 
Unspecified(14)
 
 
Top Targets:
MFS(5)
 
 
 
 
Arginase-like(1)
 
 
BioAssay Types:
Literature(49)
 
 
 
 
 
BioActivity Types:
EC50(2)
 
 
 
Ki(1)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 50    Data Row: 50   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103224325]
MIC 1.5Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by NCCLS microbroth dilution method [AID722318, Type: Literature]
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2
[SID103224325]
MIC 3Antibacterial activity against Escherichia coli ATCC 10536 after 18 hrs by broth dilution method [AID722324, Type: Literature]
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3
[SID103224325]
MIC 3.2Antibacterial activity against Klebsiella pneumoniae ATCC 27736 after 18 hrs by broth dilution method [AID722321, Type: Literature]
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4
[SID103224325]
MIC 3.2Antibacterial activity against Pseudomonas aeruginosa ATCC BAA-427 after 18 hrs by broth dilution method [AID722322, Type: Literature]
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5
[SID103224325]
MIC 5.1Antibacterial activity against Staphylococcus aureus ATCC 9144 after 18 hrs by broth dilution method [AID722327, Type: Literature]
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6
[SID103224325]
MIC 6Antibacterial activity against Staphylococcus epidermidis NRRL B-4268 after 18 hrs by broth dilution method [AID722326, Type: Literature]
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7
[SID103224325]
MIC 6Antifungal activity against Trichophyton mentagrophytes after 96 hrs by NCCLS microbroth dilution method [AID722316, Type: Literature]
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8
[SID103224325]
MIC 6Antifungal activity against Sporothrix schenckii after 72 hrs by NCCLS microbroth dilution method [AID722317, Type: Literature]
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9
[SID103224325]
MIC 6.8Antibacterial activity against Bacillus subtilis ATCC 6633 after 18 hrs by broth dilution method [AID722325, Type: Literature]
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10
[SID103224325]
MIC 8.4Antifungal activity against Aspergillus fumigatus after 72 hrs by NCCLS microbroth dilution method [AID722315, Type: Literature]
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11
[SID103224325]
MIC 8.4Antifungal activity against Cryptococcus neoformans after 72 hrs by NCCLS microbroth dilution method [AID722319, Type: Literature]
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12
[SID103224325]
MIC 9.6Antifungal activity against Candida albicans after 48 hrs by NCCLS microbroth dilution method [AID722320, Type: Literature]
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13
[SID103224325]
MIC 12.5Antibacterial activity against methicillin-resistant Staphylococcus aureus after 18 hrs by broth dilution method [AID722323, Type: Literature]
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14
[SID103224325]
Drug uptake in Escherichia coli ATCC 10536 assessed as membrane localization at 3 uM after 30 mins by confocal microscopic analysis [AID722314, Type: Literature]
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15
[SID103224325]
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha secretion at 1.5 to 4.5 uM after 12 hrs by ELISA [AID722330, Type: Literature]
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16
[SID103224325]
Drug uptake in human RBC assessed as membrane localization at 9 uM after 10 to 30 mins by confocal microscopic analysis [AID722331, Type: Literature]
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17
[SID103224325]
Binding affinity to FITC-tagged LPS assessed as induction of disintegration up to 40 uM by circular dichroism analysis [AID722294, Type: Literature]
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18
[SID103224325]
Binding affinity to LPS assessed as increase in helical structure at 36 uM by circular dichroism analysis [AID722295, Type: Literature]
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19
[SID103224325]
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL6 secretion at 1.5 to 4.5 uM after 12 hrs by ELISA [AID722296, Type: Literature]
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20
[SID103224325]
Antiinflammatory activity in mouse RAW264.7 cells assessed as downregulation of LPS-induced iNOS2 expression at 4.5 uM after 24 hrs by Western blotting analysis [AID722297, Type: Literature]
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21
[SID103224325]
Antiinflammatory activity in mouse RAW264.7 cells assessed as downregulation of LPS-induced TNFalpha expression at 4.5 uM after 24 hrs by Western blotting analysis [AID722298, Type: Literature]
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22
[SID103224325]
Binding affinity to PE/PG lipid vesicles assessed as increase in helical structure at 36 uM by circular dichroism analysis [AID722302, Type: Literature]
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23
[SID103224325]
Binding affinity to PE/PG lipid vesicles assessed as decrease in decrease in acrylamide-induced tryptophan fluorescence quenching at 1 uM [AID722304, Type: Literature]
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24
[SID103224325]
Binding affinity to PE/PG lipid vesicles assessed as induction of large blue shift at 1 uM by fluorescence assay [AID722307, Type: Literature]
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25
[SID103224325]
Induction of dissipation of diffusion potential in PC/Chol lipid vesicles by fluorescence assay [AID722308, Type: Literature]
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26
[SID103224325]
Induction of dissipation of diffusion potential in PE/PG lipid vesicles by fluorescence assay [AID722309, Type: Literature]
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27
[SID103224325]
Bactericidal activity against Staphylococcus aureus ATCC 9144 assessed as induction of membrane depolarization at up to 7 uM by DiSC3(5) staining-based fluorescence assay [AID722310, Type: Literature]
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28
[SID103224325]
Bactericidal activity against Escherichia coli ATCC 10536 assessed as induction of membrane damage at 5 uM after 30 mins by propidium iodide staining-based flow cytometric analysis [AID722312, Type: Literature]
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29
[SID46393202]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Arginase-L-Valine Complex [gi:56553820]
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30
[SID103224325]
EC50 1500Concentration required for obtaining 50% of the fluorescence intensity of copper-free calcein 1, in bovine serum albumin [AID51033, Type: Literature]
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31
[SID103224325]
Effect on rate of GTP hydrolysis in the GTP binding protein ras p21 [AID224503, Type: Literature]
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32
[SID103224325]
Bitter threshold value [AID233318, Type: Literature]
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33
[SID103224325]
Inhibition of HDAC in human Hela cells nuclear extracts assessed as residual activity at 500 uM by fluorimetric assay [AID447578, Type: Literature]
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34
[SID103224325]
Ki TP_TRANSPORTER: inhibition of L-tryptophan uptake in Xenopus laevis oocytes [AID681113, Type: other]Monocarboxylate transporter 10 [gi:81871541]
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35
[SID103224325]
Cytotoxicity against human RBC assessed as induction of membrane damage at 25 uM after 5 mins by annexin V-FITC staining-based FACS flow cytometric analysis [AID722313, Type: Literature]
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36
[SID103224325]
Binding affinity to LPS assessed as inhibition of LPS-induced LAL enzyme activation at 18 uM after 30 mins by spectrophotometric analysis [AID722038, Type: Literature]
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37
[SID103224325]
Binding affinity to LPS assessed as inhibition of LPS-induced LAL enzyme activation at 9 uM after 30 mins by spectrophotometric analysis [AID722292, Type: Literature]
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38
[SID103224325]
Binding affinity to LPS assessed as inhibition of LPS-induced LAL enzyme activation at 4.5 uM after 30 mins by spectrophotometric analysis [AID722293, Type: Literature]
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39
[SID103224325]
Cytotoxicity against human RBC assessed as induction of membrane depolarization at up to 16 uM by DiSC3(5) staining-based fluorescence assay [AID722311, Type: Literature]
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40
[SID103224325]
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 6 uM by Griess method [AID722299, Type: Literature]
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41
[SID103224325]
Partition coefficient (logP) [AID26797, Type: Literature]
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42
[SID103224325]
Cytotoxicity against mouse 3T3 cells assessed as cell viability up to 25 uM by MTT assay [AID722328, Type: Literature]
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43
[SID103224325]
Cytotoxicity against human RBC assessed as hemolysis at 60 uM [AID722329, Type: Literature]
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44
[SID103224325]
Vasodilatory activity in Wistar rat RASMC cells assessed as increase in cGMP levels at 100 uM after 5 mins by enzyme immunoassay relative to control [AID695510, Type: Literature]
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45
[SID103224325]
Binding affinity to PC/Chol lipid vesicles assessed as decrease in acrylamide-induced tryptophan fluorescence quenching at 1 uM [AID722305, Type: Literature]
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46
[SID103224325]
Binding affinity to PC/Chol lipid vesicles assessed as induction of large blue shift at 1 uM by fluorescence assay [AID722306, Type: Literature]
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47
[SID103224325]
Activation of human PEPT1 expressed in MDCK cells relative to Gly-Sar [AID266247, Type: Literature]Solute carrier family 15 member 1 [gi:1172435]
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48
[SID103224325]
Ratio of %GSmax to EC50 for human PEPT1 activation [AID266248, Type: Literature]Solute carrier family 15 member 1 [gi:1172435]
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49
[SID103224325]
IC50 Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells [AID266249, Type: Literature]Solute carrier family 15 member 1 [gi:1172435]
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50
[SID103224325]
EC50 Activation of human PEPT1 expressed in MDCK cells [AID266246, Type: Literature]Solute carrier family 15 member 1 [gi:1172435]
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