Mannitol (CID 6251) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(2)
 
 
Inactive(516)
 
 
Inconclusive(26)
 
 
Unspecified(251)
 
 
Top Targets:
7TM GPCR Srx(27)
 
 
 
7TM GPCR Srsx(15)
 
 
 
ABC MTABC3 MD..(8)
 
 
p450(8)
 
 
NR LBD PPAR(5)
 
 
BioAssay Types:
Screening(295)
 
 
 
Literature(197)
 
 
 
 
Confirmatory(148)
 
 
 
 
BioActivity Types:
IC50(150)
 
 
 
 
Potency(134)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 710    Data Row: 795   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID48416194]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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2
[SID56322640]
 Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_SinglePoint_HTS_Activity [AID504558, Type: screening]LMP1 [Human herpesvirus 4] [gi:23893668]
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3
[SID103191605]
IC50 30Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID377830, Type: Literature]
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4
[SID103191605]
IC50 30Antioxidant activity assessed as authentic peroxynitrite free radical scavenging activity after 30 mins [AID377831, Type: Literature]
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5
[SID103191605]
IC50 30Antioxidant activity assessed as 3-morpholinosydnonimine-derived peroxynitrite free radical scavenging activity after 30 mins [AID377832, Type: Literature]
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6
[SID103191605]
IC50 9600Antioxidant activity at pH 7.4 by hydroxyl radical scavenging assay [AID386915, Type: Literature]
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7
[SID103191605]
IC50 13800Hydroxyl radical scavanging activity by chemiluminescence technique in mouse thymus cells [AID114585, Type: Literature]
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8
[SID103191605]
 Binding to POPC (palmitoyl-oleolyl-phosphatidyl-choline) liposomes using biosensor system [AID156202, Type: Literature]
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9
[SID103191605]
 Binding to POPC/GMI liposomes using biosensor system [AID156204, Type: Literature]
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10
[SID103191605]
 Effect of AOS scavenger on premeture ventricular complexes PVCs, arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 100 mg/kg [AID169997, Type: Literature]
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11
[SID103191605]
 Effect of AOS scavenger on ventricular fibrillation (VF), arrhythmias induced by ischemia-reperfusion in anesthetized rat,duration at 100 mg/kg [AID174764, Type: Literature]
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12
[SID103191605]
 Effect of AOS scavenger on ventricular tachycardia (VT), arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 100 mg/kg [AID174772, Type: Literature]
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13
[SID103191605]
 Effect of AOS scavenger on ventricular fibrillation (VF), arrhythmias induced by ischemia-reperfusion in anesthetized rat,frequency,times at 100 mg/kg [AID179360, Type: Literature]
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14
[SID103191605]
 Effect of AOS scavenger on ventricular tachycardia (VT), arrhythmias induced by ischemia-reperfusion in anesthetized rat, frequency,times at 100 mg/kg [AID179367, Type: Literature]
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15
[SID103191605]
 Effect of AOS scavenger on ventricular fibrillation (VF), arrhythmias induced by ischemia-reperfusion in anesthetized rat, incidence at 100 mg/kg; 4/10 [AID183771, Type: Literature]
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16
[SID103191605]
 Effect of AOS scavenger on ventricular tachycardia (VT), arrhythmias induced by ischemia-reperfusion in anesthetized rat ,incidence at 100 mg/kg; 7/10 [AID183783, Type: Literature]
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17
[SID103191605]
 The capillary permeability of radioligand was measured in Rat brain [AID189629, Type: Literature]
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18
[SID103191605]
 Effect of compound at 0.4 M concentration on ABA accumulation in spinachleaf slices determined as fresh weight of leaves (Experiment 1) [AID204196, Type: Literature]
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19
[SID103191605]
 Effect of compound at 0.4 M concentration on ABA accumulation in spinachleaf slices determined as fresh weight of leaves (Experiment 2) [AID204317, Type: Literature]
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20
[SID103191605]
 Effect of compound at 0.4 M concentration on ABA accumulation in spinachleaf slices determined as fresh weight of leaves (Experiment 3) [AID204318, Type: Literature]
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21
[SID103191605]
 Ratio of lactulose and mannitol in cirrhotic patients of spontaneous ascitic fluid infection (Group A and B) [AID229573, Type: Literature]
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22
[SID103191605]
 Ratio of lactulose and mannitol in cirrhotic patients of sterile ascitic fluid (Group C) [AID229574, Type: Literature]
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23
[SID103191605]
 Ratio of lactulose and mannitol in healthy individuals (Group D) [AID229575, Type: Literature]
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24
[SID103191605]
 Ratio of percent compound after dosing in cirrhotic patients of spontaneous ascitic fluid infection [AID230098, Type: Literature]
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25
[SID103191605]
 Ratio of percent compound before and after dosing in cirrhotic patients of spontaneous ascitic fluid infection [AID230099, Type: Literature]
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26
[SID103191605]
 Ratio of percent compound before dosing in cirrhotic patients of spontaneous ascitic fluid infection [AID230100, Type: Literature]
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27
[SID103191605]
 Ratio of [(apical to basal)/(basal to apical)] (Caco-2 cell monolayer) [AID231333, Type: Literature]
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28
[SID103191605]
 Fraction absorbed in human intestine after oral administration compound was measured [AID236268, Type: Literature]
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29
[SID103191605]
 Permeability Coefficient in 2/4/A1 cell model [AID236912, Type: Literature]
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30
[SID103191605]
 Permeability Coefficient in Caco-2 cell culture model [AID236913, Type: Literature]
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31
[SID103191605]
 Permeability Coefficient in hexadecane membranes model [AID236914, Type: Literature]
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32
[SID103191605]
 Percentage of mass balance in hexadecane membranes model [AID236916, Type: Literature]
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33
[SID103191605]
 Tested for fraction of oral dose absorbed orally in humans [AID237585, Type: Literature]
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34
[SID103191605]
 Effective concentration required for scavenging of hydroxyl radical generation from the tentical protein of jellyfish [AID246375, Type: Literature]
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35
[SID103191605]
 Partition coefficient in multicellular layers of HT-29 human colon carcinoma cells [AID249256, Type: Literature]
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36
[SID103191605]
 Absorptive permeability across Caco-2 cell membrane [AID268372, Type: Literature]
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37
[SID103191605]
 Exsorptive permeability across Caco-2 cell membrane [AID268373, Type: Literature]
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38
[SID103191605]
 Apparent permeability across human Caco-2 cells [AID288201, Type: Literature]
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39
[SID103191605]
 Apparent permeability across human Caco-2 cells [AID299831, Type: Literature]
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40
[SID103191605]
 Permeability across human Caco-2 cell monolayer [AID303796, Type: Literature]
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41
[SID103191605]
 Percent of compound in cirrhotic patients of spontaneous ascitic fluid infection (Group A and B) [AID7585, Type: Literature]
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42
[SID103191605]
 Percent of compound in cirrhotic patients of spontaneous ascitic fluid infection after dosing with normal antibiotics [AID7586, Type: Literature]
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43
[SID103191605]
 Percent of compound in cirrhotic patients of spontaneous ascitic fluid infection after dosing with normal antibiotics and lactose [AID7587, Type: Literature]
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44
[SID103191605]
 Percent of compound in cirrhotic patients of spontaneous ascitic fluid infection before dosing with normal antibiotics [AID7588, Type: Literature]
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45
[SID103191605]
 Percent of compound in cirrhotic patients of spontaneous ascitic fluid infection before dosing with normal antibiotics and lactose [AID7589, Type: Literature]
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46
[SID103191605]
 Percent of compound in cirrhotic patients of sterile ascitic fluid (Group C) [AID7590, Type: Literature]
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47
[SID103191605]
 Percent of compound in healthy individuals (Group D) [AID7591, Type: Literature]
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48
[SID103191605]
 Oral bioavailability in human [AID7779, Type: Literature]
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49
[SID103191605]
 In vitro rate of absorption observed as Caco-2 permeability in humans [AID7812, Type: other]
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50
[SID103191605]
 Metabolic stability observed at 30 min after administration in human liver microsomes [AID7974, Type: Literature]
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