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BioActivity Data for Compound Mannitol (CID 6251)

BioActivity Outcomes:
Active(2)
 
 
Inactive(905)
 
 
Inconclusive(40)
 
 
Unspecified(361)
 
 
Top Targets:
7tm 4(67)
 
 
 
NR LBD PPAR(29)
 
 
NR LBD ER(25)
 
 
 
 
NR LBD AR(24)
 
 
 
 
NR LBD VDR(16)
 
 
BioAssay Types:
Confirmatory(517)
 
 
 
 
Screening(355)
 
 
 
Literature(213)
 
 
 
 
Summary(84)
 
 
 
BioAssay Categories:
In vitro(142)
 
 
In vivo(103)
 
 
 
Biochemical(245)
 
 
 
Toxicity(134)
 
 
 
 
ADME(82)
 
 
 
Cell-based(228)
 
 
 
 
Organism-base..(12)
 
 
BioActivity Types:
Potency(446)
 
 
 
 
IC50(150)
 
 
 
 
AC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 978    Data Row: 1308   Total Pages: 66   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID48416194]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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2
[SID56322640]
Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_SinglePoint_HTS_Activity [AID504558, Type: screening]LMP1 [Human herpesvirus 4] [gi:23893668]
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3
[SID103191605]
IC50 30Antioxidant activity assessed as authentic peroxynitrite free radical scavenging activity after 30 mins [AID377831, Type: Literature]
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4
[SID103191605]
IC50 30Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID377830, Type: Literature]
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5
[SID103191605]
IC50 30Antioxidant activity assessed as 3-morpholinosydnonimine-derived peroxynitrite free radical scavenging activity after 30 mins [AID377832, Type: Literature]
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6
[SID103191605]
IC50 9600Antioxidant activity at pH 7.4 by hydroxyl radical scavenging assay [AID386915, Type: Literature]
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7
[SID103191605]
IC50 13800Hydroxyl radical scavenging activity by chemiluminescence technique in mouse thymus cells [AID114585, Type: Literature]
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8
[SID103191605]
Compound was tested for its ability to inhibit DNA strand scission induced by resveratrol and Cu2+, at concentration 50 mM [AID69151, Type: Literature]
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9
[SID103191605]
Apparent Permeability through Caco-2 cell monolayers (n = 4) [AID45119, Type: Literature]
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10
[SID103191605]
Tested for fraction of oral dose absorbed orally in humans [AID237585, Type: Literature]
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11
[SID103191605]
Apparent permeability across human Caco-2 cells [AID299831, Type: Literature]
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12
[SID103191605]
Apparent permeability across rat small intestine [AID303925, Type: Literature]
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13
[SID103191605]
Apparent permeability across Caco-2 cells [AID303926, Type: Literature]
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14
[SID103191605]
Effect of AOS scavenger on ventricular tachycardia (VT), arrhythmias induced by ischemia-reperfusion in anesthetized rat, frequency, times at 100 mg/kg [AID179367, Type: Literature]
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15
[SID103191605]
Effect of AOS scavenger on ventricular fibrillation (VF), arrhythmias induced by ischemia-reperfusion in anesthetized rat, frequency, times at 100 mg/kg [AID179360, Type: Literature]
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16
[SID103191605]
Effect of AOS scavenger on ventricular tachycardia (VT), arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 100 mg/kg [AID174772, Type: Literature]
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17
[SID103191605]
Effect of AOS scavenger on ventricular fibrillation (VF), arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 100 mg/kg [AID174764, Type: Literature]
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18
[SID103191605]
Effect of AOS scavenger on premeture ventricular complexes PVCs, arrhythmias induced by ischemia-reperfusion in anesthetized rat, duration at 100 mg/kg [AID169997, Type: Literature]
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19
[SID103191605]
DrugMatrix: Regimen: Daily Repeat; Time: 5 day; Dose: High; Vehicle: 100 % saline; Route: intravenous | Dataset: Biochemistry; Assay: CREAT (Creatinine); Study_ID: S020930 [AID976318, Type: other]
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20
[SID103191605]
DrugMatrix: Regimen: Daily Repeat; Time: 5 day; Dose: High; Vehicle: 100 % saline; Route: intravenous | Dataset: Biochemistry; Assay: CHOL (Cholesterol); Study_ID: S020930 [AID976317, Type: other]
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