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bromoacetate (CID 6227) - Compound BioActivity Data
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BioActivity Outcomes:
Inactive(233)
 
 
Inconclusive(14)
 
 
Unspecified(16)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
NR LBD ER(9)
 
 
NR LBD AR(9)
 
 
NR LBD TR(7)
 
 
NR LBD VDR(6)
 
 
BioAssay Types:
Confirmatory(212)
 
 
 
Summary(24)
 
 
 
Literature(16)
 
 
 
BioActivity Types:
Potency(193)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 250    Data Row: 263   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103246073]
Ki 77000Dissociation constant towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrate [AID165176, Type: Literature]
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2
[SID103246073]
Ratio between dissociation constant and First-order rate constant (Ki / K inact) was determined [AID227010, Type: Literature]
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3
[SID103246073]
Mutagenic activity in Salmonella Typhimurium TA100 assessed as logarithm of his+ revertant number increasing activity by amens test [AID384212, Type: Literature]
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4
[SID103246073]
Dissociation constant, pKa of the compound [AID448096, Type: Literature]
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5
[SID103246073]
The compound was tested for the ability to inactivate human liver alcohol dehydrogenase in the absence of NAD+K [AID33866, Type: Literature]
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6
[SID103246073]
The compound was tested for the ability to inactivate mouse liver alcohol dehydrogenase in the absence of NAD+K [AID33871, Type: Literature]
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7
[SID103246073]
The compound was tested for the ability to inactivate mouse liver alcohol dehydrogenase in the presence of 1 mM NAD+K; Slow inactivation [AID33873, Type: Literature]
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8
[SID103246073]
The compound was tested for the ability to inactivate rat liver alcohol dehydrogenase in the absence of NAD+K [AID33878, Type: Literature]
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9
[SID103246073]
The compound was tested for the ability to inactivate rat liver alcohol dehydrogenase in the presence of 1 mM NAD+K [AID33879, Type: Literature]
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10
[SID103246073]
First-order rate constant (K inact) for conversion of the ExI complex (Protein-tyrosine phosphatase 1B -inhibitor complex) into the covalent adduct, EI was determined using PNP as substrate [AID165175, Type: Literature]
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11
[SID103246073]
The compound was tested for the ability to inactivate horse liver alcohol dehydrogenase in the absence of NAD+k [AID33714, Type: Literature]Alcohol dehydrogenase E chain [gi:113397]
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12
[SID103246073]
The compound was tested for the ability to inactivate horse liver alcohol dehydrogenase in the presence of 1 mM NAD+k [AID33719, Type: Literature]Alcohol dehydrogenase E chain [gi:113397]
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13
[SID103246073]
The compound was tested for the ability to inactivate horse liver alcohol dehydrogenase in the presence of 1 mM NAD+k [AID33719, Type: Literature]Alcohol dehydrogenase S chain [gi:113406]
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14
[SID103246073]
The compound was tested for the ability to inactivate horse liver alcohol dehydrogenase in the absence of NAD+k [AID33714, Type: Literature]Alcohol dehydrogenase S chain [gi:113406]
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15
[SID103246073]
Partition coefficient (logP) [AID23443, Type: Literature]
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16
[SID17389676]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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17
[SID144207855]
Potency-Replicate_1 0.1871qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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18
[SID17389676]
Potency 5.0119qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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19
[SID17389676]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase 1 [gi:44888968]
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20
[SID17389676]
Potency qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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21
[SID17389676]
Potency qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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22
[SID144207855]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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23
[SID144207855]
AhR Potency (uM) qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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24
[SID17389676]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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25
[SID17389676]
qHTS Assay for Inhibitors of YjeE [AID605, Type: confirmatory]tRNA threonylcarbamoyladenosine biosynthesis protein TsaE [gi:84028058]
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26
[SID17389676]
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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27
[SID17389676]
qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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28
[SID17389676]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID584, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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29
[SID17389676]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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30
[SID17389676]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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31
[SID144207855]
qHTS assay to identify aromatase inhibitors: Summary [AID743139, Type: summary]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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32
[SID144207855]
Potency-Replicate_1 qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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33
[SID17389676]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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34
[SID17389676]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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35
[SID17389676]
Potency qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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36
[SID17389676]
Potency qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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37
[SID17389676]
Potency qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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38
[SID17389676]
Potency qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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39
[SID17389676]
Potency qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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40
[SID17389676]
Potency qHTS assay for small molecule antagonists of androgen receptor signaling [AID588516, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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41
[SID144207855]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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42
[SID144207855]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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43
[SID144207855]
AR Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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44
[SID144207855]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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45
[SID144207855]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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46
[SID144207855]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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47
[SID144207855]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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48
[SID17389676]
Potency qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID1452, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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49
[SID17389676]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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50
[SID17389676]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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