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Cycloheximide (CID 6197) - Compound BioActivity Data
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BioActivity Outcomes:
Active(725)
 
 
Inactive(793)
 
 
Inconclusive(280)
 
 
Unspecified(323)
 
 
Top Targets:
NR LBD PPAR(39)
 
 
 
 
7TM GPCR Srx(35)
 
 
 
7TM GPCR Srsx(32)
 
 
 
NR LBD ER(29)
 
 
 
 
 
NR LBD AR(28)
 
 
 
 
 
BioAssay Types:
Confirmatory(790)
 
 
 
 
 
Screening(345)
 
 
 
 
Literature(312)
 
 
 
 
 
Summary(72)
 
 
 
 
BioActivity Types:
Potency(657)
 
 
 
 
 
IC50(201)
 
 
 
 
 
EC50(18)
 
 
 
 
Ki(10)
 
 
 
AC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1318    Data Row: 2121   Total Pages: 43   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17389082]
Potency 0.0089VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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2
[SID144213954]
Potency-Replicate_1 0.0217qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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3
[SID103348651]
IC50 0.032Antimicrobial activity against Saccharomyces cerevisiae JB503 [AID501242, Type: Literature]
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4
[SID144213954]
Potency-Replicate_1 0.0344qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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5
[SID103348651]
IC50 0.036Inhibition of hypoxia-induced HIF1 activation in human HeLa cells by luciferase reporter gene assay [AID402342, Type: Literature]
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6
[SID144213954]
Potency-Replicate_1 0.0386qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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7
[SID103348651]
EC50 0.042Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay [AID521214, Type: Literature]
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8
[SID144213954]
Potency-Replicate_1 0.0433qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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9
[SID103348651]
IC50 0.047HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells [AID685501, Type: other]
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10
[SID144207129]
Potency 0.0473qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID103348651]
EC50 0.054Antiproliferative activity against mouse neural precursor cells by colony formation assay [AID521215, Type: Literature]
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12
[SID144207129]
TR Potency (uM) 0.0595572qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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13
[SID144207129]
Potency 0.0596qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID144207129]
Potency-Replicate_1 0.0596qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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15
[SID144208356]
Potency-Replicate_1 0.0608qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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16
[SID144208356]
Potency-Replicate_1 0.0608qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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17
[SID144213954]
Potency-Replicate_1 0.0616qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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18
[SID144207129]
Potency-Replicate_1 0.0668qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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19
[SID103348651]
EC50 0.071Antiproliferative activity against mouse astrocyte cells by MTT assay [AID521209, Type: Literature]
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20
[SID103348651]
MIC 0.071Minimum inhibitory concentration against Benjaminiella poitrassi [AID41737, Type: Literature]
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21
[SID103348651]
IC50 0.0781NOVARTIS: Antimalarial liver stage activity measured as reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells by immuno-fluorescence, and median schizont size at 10uM compound concentration [AID602119, Type: other]
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22
[SID131332686]
IC50 0.0781Novartis GNF Liver Stage Dataset: Malariabox Annotation [AID602156, Type: Literature]
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23
[SID17389082]
Potency 0.0794qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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24
[SID103348651]
IC50 0.08Cytotoxicity was determined in CEM cells, relative to RVT [AID47311, Type: Literature]
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25
[SID103348651]
IC50 0.088Antimicrobial activity against Saccharomyces cerevisiae J47alpha [AID501241, Type: Literature]
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26
[SID144213954]
Potency-Replicate_1 0.0969qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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27
[SID144208356]
Potency-Replicate_1 0.0972qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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28
[SID103348651]
IC50 0.1Inhibition of Plasmodium falciparum FCK2 growth as [3H]hypoxanthine uptake after 96 hrs [AID278577, Type: Literature]
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29
[SID56463698]
Potency 0.1042Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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30
[SID56463698]
Potency 0.1042Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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31
[SID103348651]
MIC 0.106Minimum inhibitory concentration against Yarrowia lipolytica [AID220090, Type: Literature]
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32
[SID144208356]
Potency-Replicate_1 0.108qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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33
[SID144208356]
Potency-Replicate_1 0.108qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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34
[SID103348651]
EC50 0.1135NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay [AID449703, Type: other]
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35
[SID144207129]
Potency-Replicate_1 0.1188qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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36
[SID124883128]
Potency 0.1189qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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37
[SID103348651]
IC50 0.12Tested in vitro for anticancer activity against CEM cells [AID47449, Type: Literature]
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38
[SID144208356]
Potency-Replicate_1 0.1212qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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39
[SID17389083]
Potency 0.1259qHTS assay for cell viability of HEK293 cells [AID743288, Type: confirmatory]
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40
[SID144207129]
Potency-Replicate_1 0.1333qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
View
41
[SID103348651]
EC50 0.142Antiproliferative activity against mouse neural precursor cells by MTT assay [AID521208, Type: Literature]
View
42
[SID124883128]
Potency 0.1496qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
43
[SID17389082]
Potency 0.1496qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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44
[SID103348651]
IC50 0.15Inhibition of Plasmodium falciparum FCK2 growth as [3H]hypoxanthine uptake after 48 hrs [AID278576, Type: Literature]
View
45
[SID144213954]
Potency-Replicate_1 0.1536qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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46
[SID144213954]
Potency-Replicate_1 0.1548qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway [AID743212, Type: confirmatory]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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47
[SID56463698]
AbsAC40_uM 0.16HTS for suppressors of simvastatin-induced mytoxicity in differentiated C2C12 cells Measured in Cell-Based System Using Plate Reader - 2112-01_Other_Dose_CherryPick_Activity [AID624405, Type: confirmatory]
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48
[SID56463698]
Potency 0.1636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
49
[SID56463698]
Potency 0.1636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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50
[SID103348651]
EC50 0.1817NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay [AID449704, Type: other]
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