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Cycloheximide (CID 6197) - Compound BioActivity Data
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BioActivity Outcomes:
Active(713)
 
 
Inactive(785)
 
 
Inconclusive(233)
 
 
Unspecified(1051)
 
 
Top Targets:
7tm 4(67)
 
 
 
NR LBD PPAR(31)
 
 
 
 
NR LBD ER(22)
 
 
 
 
 
NR LBD AR(21)
 
 
 
 
 
NR LBD TR(20)
 
 
 
 
BioAssay Types:
Confirmatory(845)
 
 
 
 
 
Screening(346)
 
 
 
 
Literature(345)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(580)
 
 
 
 
 
IC50(201)
 
 
 
 
 
EC50(18)
 
 
 
 
Ki(10)
 
 
 
AC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2057    Data Row: 2782   Total Pages: 140   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17389082]
Potency 0.0089VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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2
[SID103348651]
IC50 0.032Antimicrobial activity against Saccharomyces cerevisiae JB503 [AID501242, Type: Literature]
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3
[SID103348651]
IC50 0.036Inhibition of hypoxia-induced HIF1 activation in human HeLa cells by luciferase reporter gene assay [AID402342, Type: Literature]
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4
[SID103348651]
EC50 0.042Antiproliferative activity against mouse medulloblastoma cells harboring heterozygous ptch1 gene by MTT assay [AID521214, Type: Literature]
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5
[SID103348651]
IC50 0.047HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells [AID685501, Type: Literature]
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6
[SID144207129]
Potency 0.0473qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID103348651]
EC50 0.054Antiproliferative activity against mouse neural precursor cells by colony formation assay [AID521215, Type: Literature]
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8
[SID144207129]
TR Potency (uM) 0.0595572qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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9
[SID144207129]
Potency 0.0596qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID144207129]
Potency-Replicate_1 0.0596qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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11
[SID144208356]
Potency-Replicate_1 0.0608qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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12
[SID144208356]
Potency-Replicate_1 0.0608qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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13
[SID144207129]
Potency-Replicate_1 0.0668qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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14
[SID103348651]
EC50 0.071Antiproliferative activity against mouse astrocyte cells by MTT assay [AID521209, Type: Literature]
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15
[SID103348651]
IC50 0.0781NOVARTIS: Antimalarial liver stage activity measured as reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells by immuno-fluorescence, and median schizont size at 10uM compound concentration [AID602119, Type: Literature]
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16
[SID131332686]
IC50 0.0781Novartis GNF Liver Stage Dataset: Malariabox Annotation [AID602156, Type: Literature]
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17
[SID17389082]
Potency 0.0794qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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18
[SID103348651]
IC50 0.08Cytotoxicity was determined in CEM cells, relative to RVT [AID47311, Type: Literature]
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19
[SID103348651]
IC50 0.088Antimicrobial activity against Saccharomyces cerevisiae J47alpha [AID501241, Type: Literature]
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20
[SID144208356]
Potency-Replicate_1 0.0972qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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