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BioActivity Data for Compound Cytidine Triphosphate (CID 6176)

BioActivity Outcomes:
Active(9)
 
 
Unspecified(5)
 
 
Top Targets:
G1P cytidylyl..(3)
 
 
CTGs(1)
 
 
P-loop NTPase(1)
 
 
dNK(1)
 
 
BioAssay Types:
Literature(14)
 
 
 
BioAssay Categories:
Biochemical(8)
 
 
 
Cell-based(1)
 
 
BioActivity Types:
Ki(4)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 10    Data Row: 14   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103511679]
Km 2.7Activity of HCV NS5B RNA polymerase S282T assessed as incorporation of 32P-UMP into RNA [AID278952, Type: Literature]
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2
[SID103511679]
Km 13.7Activity of HCV NS5B RNA polymerase assessed as incorporation of 32P-UMP into RNA [AID278951, Type: Literature]
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3
[SID46393514]
Ki 35Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Alpha-D-Glucose-1-Phosphate Cytidylyltransferase Complexed With Ctp [gi:60593932]
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4
[SID46393514]
Ki 35Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Alpha-D-Glucose-1-Phosphate Cytidylyltransferase Complexed With Ctp [gi:60593932]
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5
[SID46393790]
Ki 110Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain B, Mechanisms Of Feedback Regulation And Drug Resistance Of Ctp Synthetases: Structure Of The E. Coli Ctps/ctp Complex At 2.8- Angstrom Resolution. [gi:82407749]
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6
[SID46393790]
Ki 110Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain B, Mechanisms Of Feedback Regulation And Drug Resistance Of Ctp Synthetases: Structure Of The E. Coli Ctps/ctp Complex At 2.8- Angstrom Resolution. [gi:82407749]
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7
[SID46393790]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Mechanisms Of Feedback Regulation And Drug Resistance Of Ctp Synthetases: Structure Of The E. Coli Ctps/ctp Complex At 2.8- Angstrom Resolution. [gi:82407748]
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8
[SID46393514]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Alpha-D-Glucose-1-Phosphate Cytidylyltransferase Complexed With Ctp [gi:60593932]
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9
[SID103511679]
IC50 Inhibition of RNA synthesis activity of HSV 1b Con1 NS5B polymerase [AID386066, Type: Literature]
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10
[SID103511679]
Effect on thymidine kinase in BHK21 (C13) cells using [14C]thymidine at 5 mM after 10 mins by liquid scintillation spectrometer analysis relative to control in presence of Mg2+ [AID1124515, Type: Literature]Thymidine kinase, cytosolic [gi:125428]
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11
[SID103511679]
Effect on human cytoplasmic thymidine kinase using [14C]thymidine at 5 mM after 10 mins by liquid scintillation spectrometer analysis relative to control in presence of Mg2+ [AID1124517, Type: Literature]Thymidine kinase, cytosolic [gi:23503074]
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12
[SID103511679]
Ratio of Kcat to Km for HCV NS5B RNA polymerase [AID278942, Type: Literature]
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13
[SID103511679]
Ratio of Kcat to Km for HCV NS5B RNA polymerase S282T mutant [AID278943, Type: Literature]
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14
[SID103511679]
Effect on human mitochondrial thymidine kinase using [14C]thymidine at 5 mM after 10 mins by liquid scintillation spectrometer analysis relative to control in presence of Mg2+ [AID1124518, Type: Literature]Thymidine kinase 2, mitochondrial [gi:254763443]
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