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Cytidine (CID 6175) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inactive(371)
 
 
Inconclusive(1)
 
 
Unspecified(33)
 
 
Top Targets:
7tm 4(23)
 
 
PLDc mTdp1 2(5)
 
 
RasGEF(4)
 
 
ABCC CFTR1(4)
 
 
CAP ED(4)
 
 
BioAssay Types:
Screening(218)
 
 
Confirmatory(142)
 
 
 
 
Literature(42)
 
 
 
 
BioActivity Types:
Potency(134)
 
 
 
IC50(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 360    Data Row: 407   Total Pages: 21   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103313321]
Km 6.6Activity of human dCK expressed in HepG2 cells assessed as phosphorylation by coupled enzyme assay [AID278932, Type: Literature]Deoxycytidine kinase [gi:118447]
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2
[SID103313321]
Km 40Activity of cloned cytidine deaminase in human HuH7 cells by spectrophotometric analysis [AID431226, Type: Literature]Cytidine deaminase [gi:1705718]
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3
[SID103313321]
IC50 30Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID377830, Type: Literature]
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4
[SID103313321]
IC50 30Antioxidant activity assessed as authentic peroxynitrite free radical scavenging activity after 30 mins [AID377831, Type: Literature]
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5
[SID103313321]
IC50 30Antioxidant activity assessed as 3-morpholinosydnonimine-derived peroxynitrite free radical scavenging activity after 30 mins [AID377832, Type: Literature]
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6
[SID103313321]
Km 50Michaelis-Menten constant was determined against cytidine deaminase [AID18296, Type: Literature]
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7
[SID103313321]
Km 131Activity of human UCK1 expressed in Huh7 cells assessed as phosphorylation by coupled enzyme assay [AID278936, Type: Literature]Uridine-cytidine kinase 1 [gi:20455360]
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8
[SID103313321]
Ratio of Kcat to Km for UCK1 activity expressed in Huh7 cells [AID278937, Type: Literature]Uridine-cytidine kinase 1 [gi:20455360]
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9
[SID103313321]
Partition coefficient (logP) [AID28713, Type: Literature]
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10
[SID103313321]
Inhibition of cytidine deaminase partially purified from mouse kidney. [AID55385, Type: Literature]
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11
[SID103313321]
The concentration required to inhibit the growth of L-1210 leukemic cells was evaluated; 1E-3 to 1E-4 [AID97844, Type: Literature]
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12
[SID103313321]
The concentration requiredi (cytidine+2'deoxycytidine) to inhibit the growth of L-1210 leukemic cells was evaluated [AID97847, Type: Literature]
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13
[SID103313321]
Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-13 cell line [AID102529, Type: Literature]
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14
[SID103313321]
Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-3 cell line [AID102530, Type: Literature]
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15
[SID103313321]
Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-8 cell line [AID102531, Type: Literature]
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16
[SID103313321]
Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-9 cell line [AID102532, Type: Literature]
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17
[SID103313321]
Inhibitory effect tested in vitro for the growth of Lung squamous-cell carcinoma QG-56 cell line [AID102684, Type: Literature]
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18
[SID103313321]
Ability to inhibit rat mitochondrial thymidine kinase [AID126601, Type: Literature]
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19
[SID103313321]
Inhibitory effect tested in vitro for the growth of Osteosarcoma KHOS-321H cell line [AID151162, Type: Literature]
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20
[SID103313321]
Inhibitory effect tested in vitro for the growth of Osteosarcoma MNNG-HOS cell line [AID151163, Type: Literature]
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