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Cytidine (CID 6175) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inactive(364)
 
 
Inconclusive(1)
 
 
Unspecified(31)
 
 
Top Targets:
7TM GPCR Srx(12)
 
 
7TM GPCR Srsx(11)
 
 
PLDc mTdp1 2(5)
 
 
RasGEF(4)
 
 
ABCC CFTR1(4)
 
 
BioAssay Types:
Screening(217)
 
 
Confirmatory(142)
 
 
 
 
Literature(34)
 
 
 
 
BioActivity Types:
Potency(134)
 
 
 
IC50(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 357    Data Row: 398   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103313321]
Km 6.6Activity of human dCK expressed in HepG2 cells assessed as phosphorylation by coupled enzyme assay [AID278932, Type: Literature]Deoxycytidine kinase [gi:118447]
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2
[SID103313321]
Km 40Activity of cloned cytidine deaminase in human HuH7 cells by spectrophotometric analysis [AID431226, Type: Literature]Cytidine deaminase [gi:1705718]
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3
[SID103313321]
IC50 30Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID377830, Type: Literature]
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4
[SID103313321]
IC50 30Antioxidant activity assessed as authentic peroxynitrite free radical scavenging activity after 30 mins [AID377831, Type: Literature]
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5
[SID103313321]
IC50 30Antioxidant activity assessed as 3-morpholinosydnonimine-derived peroxynitrite free radical scavenging activity after 30 mins [AID377832, Type: Literature]
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6
[SID103313321]
Km 50Michaelis Menten constant was determined against cytidine deaminase [AID18296, Type: Literature]
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7
[SID103313321]
Km 131Activity of human UCK1 expressed in Huh7 cells assessed as phosphorylation by coupled enzyme assay [AID278936, Type: Literature]Uridine-cytidine kinase 1 [gi:20455360]
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8
[SID103313321]
Ratio of Kcat to Km for UCK1 activity expressed in Huh7 cells [AID278937, Type: Literature]Uridine-cytidine kinase 1 [gi:20455360]
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9
[SID103313321]
Partition coefficient (logP) [AID28713, Type: Literature]
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10
[SID103313321]
Inhibition of cytidine deaminase partially purified from mouse kidney. [AID55385, Type: Literature]
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11
[SID103313321]
The concentration required to inhibit the growth of L-1210 leukemic cells was evaluated; 1E-3 to 1E-4 [AID97844, Type: Literature]
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12
[SID103313321]
The concentration requiredi (cytidine+2'deoxycytidine) to inhibit the growth of L-1210 leukemic cells was evaluated [AID97847, Type: Literature]
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13
[SID103313321]
Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-13 cell line [AID102529, Type: Literature]
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14
[SID103313321]
Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-3 cell line [AID102530, Type: Literature]
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15
[SID103313321]
Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-8 cell line [AID102531, Type: Literature]
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16
[SID103313321]
Inhibitory effect tested in vitro for the growth of Lung adenocarcinoma PC-9 cell line [AID102532, Type: Literature]
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17
[SID103313321]
Inhibitory effect tested in vitro for the growth of Lung squamous-cell carcinoma QG-56 cell line [AID102684, Type: Literature]
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18
[SID103313321]
Ability to inhibit rat mitochondrial thymidine kinase [AID126601, Type: Literature]
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19
[SID103313321]
Inhibitory effect tested in vitro for the growth of Osteosarcoma KHOS-321H cell line [AID151162, Type: Literature]
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20
[SID103313321]
Inhibitory effect tested in vitro for the growth of Osteosarcoma MNNG-HOS cell line [AID151163, Type: Literature]
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21
[SID103313321]
Inhibitory effect tested in vitro for the growth of Osteosarcoma OST cell line [AID151164, Type: Literature]
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22
[SID103313321]
Inhibitory effect tested in vitro for the growth of Osteosarcoma SK-ES-1 cell line [AID151165, Type: Literature]
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23
[SID103313321]
Phosphorylation by uridine/cytidine kinase(UCK) from mouse sarcoma -180 ascites cells was measured. [AID201571, Type: Literature]
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24
[SID103313321]
Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma MKN- 28 cell line [AID205927, Type: Literature]
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25
[SID103313321]
Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma NUGC-4 cell line [AID205930, Type: Literature]
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26
[SID103313321]
Inhibitory effect tested in vitro for the growth of Stomach adenocarcinoma ST-KM cell line [AID205931, Type: Literature]
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27
[SID103313321]
Ability to inhibit rat cytoplasmic Thymidine kinase [AID210890, Type: Literature]
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28
[SID103313321]
Inhibitory effect tested in vitro for the growth of colon adenocarsinoma SW-480 cell line [AID219877, Type: Literature]
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29
[SID103313321]
Contractile activity in guinea pig ileum at 1200 ug/ml relative to histamine [AID334938, Type: other]
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30
[SID103313321]
Inhibition of electrically-stimulated contraction in guinea pig ileum at 1200 ug/ml [AID334944, Type: other]
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31
[SID103313321]
Ratio of Kcat to Km for cloned cytidine deaminase in human HuH7 cells by spectrophotometric analysis [AID431228, Type: Literature]Cytidine deaminase [gi:1705718]
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32
[SID103313321]
Ratio of Kcat to Km for human dCK expressed in HepG2 cells [AID278933, Type: Literature]Deoxycytidine kinase [gi:118447]
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33
[SID93576752]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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34
[SID174007401]
Potency 0.0024qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation [AID743345, Type: confirmatory]
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35
[SID26754267]
Potency 0.3548qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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36
[SID174007401]
Potency 23.6945qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (HB3) proliferation [AID743347, Type: confirmatory]
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37
[SID93576752]
Potency 56.2341HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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38
[SID93576752]
Identification of agents that induce E-selectin on human endothelial cells Measured in Cell-Based System Using Imaging - 2152-01_Activator_SinglePoint_HTS_Activity [AID686992, Type: screening]E-selectin precursor [Homo sapiens] [gi:187960042]
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39
[SID26754267]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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40
[SID26754267]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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41
[SID26754267]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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42
[SID26754267]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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43
[SID93576752]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. [AID504734, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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44
[SID93576752]
Luminescence-based cell-based high throughput primary screening assay to identify agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID602229, Type: screening]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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45
[SID93576752]
Identification of inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_SinglePoint_HTS_Activity [AID602329, Type: screening]DNA repair and recombination protein RAD54-like [Homo sapiens] [gi:216548193]
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46
[SID93576752]
Fluorescent Biochemical Primary HTS to Identify Inhibitors of P. aeruginosa PvdQ acylase Measured in Biochemical System Using Plate Reader and Imaging Combination - 2091-01_Inhibitor_SinglePoint_HTS_Activity [AID488965, Type: screening]protein PvdQ [Pseudomonas aeruginosa LESB58] [gi:218891639]
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47
[SID93576752]
Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of human diacylglycerol lipase, beta (DAGLB) [AID504411, Type: screening]sn1-specific diacylglycerol lipase beta isoform 1 [Homo sapiens] [gi:218931251]
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48
[SID93576752]
IC50 Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocysteine [gi:219689243]
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49
[SID26754267]
Potency qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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50
[SID93576752]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). [AID720700, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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