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BioActivity Data for Compound Colchicine (CID 6167)

BioActivity Outcomes:
Active(1336)
 
 
Inactive(1307)
 
 
Inconclusive(353)
 
 
Unspecified(1954)
 
 
Top Targets:
beta tubulin(114)
 
 
 
7tm 4(75)
 
 
 
 
alpha tubulin(61)
 
 
 
p450(39)
 
 
 
 
 
NR LBD PPAR(39)
 
 
 
BioAssay Types:
Literature(1469)
 
 
 
 
 
Confirmatory(1274)
 
 
 
 
 
Screening(429)
 
 
 
 
Summary(73)
 
 
 
 
BioAssay Categories:
In vitro(205)
 
 
 
 
 
In vivo(1271)
 
 
 
 
 
Biochemical(527)
 
 
 
 
 
Toxicity(1625)
 
 
 
 
 
ADME(107)
 
 
 
 
 
Cell-based(1133)
 
 
 
 
 
Organism-base..(15)
 
 
 
BioActivity Types:
Potency(938)
 
 
 
 
 
IC50(794)
 
 
 
 
 
EC50(54)
 
 
 
 
 
AC50(17)
 
 
 
 
Ki(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 3691    Data Row: 4950   Total Pages: 248   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177124]
IC50 0.00062The compound was evaluated in vitro for the inhibition of murine leukemia P388D1 cell proliferation. [AID225070, Type: confirmatory]
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2
[SID103177124]
ED50 0.001Cytotoxicity against human melanoma RPMI-7951 cell line [AID167041, Type: Literature]
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3
[SID103177124]
ED50 0.001Cytotoxicity against human central nervous system carcinoma TE671 cell line [AID208873, Type: Literature]
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4
[SID103177124]
IC50 0.0011Antiproliferative activity against human HT1080 cells after 48 hrs by sulforhodamine B assay [AID605766, Type: Literature]
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5
[SID103177124]
IC50 0.0011Antiproliferative activity against human HT1080 after 48 hrs by SRB assay [AID627401, Type: Literature]
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6
[SID103177124]
Ki 0.00161Binding affinity to pig brain tubulin [AID711185, Type: Literature]
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7
[SID170465011]
IC50 0.0017Increased HeLa cells with 2N DNA content-IC50 [AID1117349, Type: confirmatory]
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8
[SID103177124]
GI50 0.0017Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program [AID247402, Type: Literature]
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9
[SID103177124]
IC50 0.0017Displacement of [3H]colchicine from tubulin by scintillation proximity assay [AID391282, Type: Literature]
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10
[SID170465011]
IC50 0.00171Increased HeLa cells with 4N DNA content-IC50 [AID1117351, Type: confirmatory]
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11
[SID170465011]
IC50 0.00173Increased chromatin condensation in HeLa cells-IC50 [AID1117350, Type: confirmatory]
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12
[SID103177124]
IC50 0.0018Anti tumor activity on human breast cancer cell line MDR-negative MDA-MB 231 after 72 hours of treatment [AID101630, Type: Literature]
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13
[SID103177124]
IC50 0.00184Cytotoxicity against HeLa cell line [AID277280, Type: Literature]
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14
[SID170465011]
IC50 0.00188Decreased HeLa cell count-IC50 [AID1117347, Type: confirmatory]
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15
[SID103177124]
ED50 0.002Cytotoxicity against human solid tumor nasopharyngeal carcinoma KB cell line [AID95523, Type: Literature]
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16
[SID103177124]
IC50 0.0021Antiproliferative activity against human SKOV3 after 48 hrs by SRB assay [AID627403, Type: Literature]
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17
[SID103177124]
IC50 0.0021Antiproliferative activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay [AID605768, Type: Literature]
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18
[SID103177124]
IC50 0.0021Cytotoxicity against human MDA-MB-468 cells assessed as cell viability after 4 days by MTS assay [AID1058421, Type: Literature]
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19
[SID103177124]
IC50 0.0026Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay [AID744714, Type: Literature]
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20
[SID103177124]
IC50 0.00275Cytotoxicity against HCT116 cell line [AID277278, Type: Literature]
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