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Colchicine (CID 6167) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1271)
 
 
Inactive(1288)
 
 
Inconclusive(353)
 
 
Unspecified(1911)
 
 
Top Targets:
beta tubulin(84)
 
 
 
7tm 4(75)
 
 
 
 
alpha tubulin(43)
 
 
 
NR LBD PPAR(39)
 
 
 
p450(39)
 
 
 
 
 
BioAssay Types:
Literature(1396)
 
 
 
 
 
Confirmatory(1240)
 
 
 
 
 
Screening(416)
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
Potency(938)
 
 
 
 
 
IC50(760)
 
 
 
 
 
EC50(52)
 
 
 
 
 
Ki(8)
 
 
 
AC50(5)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 3612    Data Row: 4823   Total Pages: 242   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177124]
IC50 0.00062The compound was evaluated in vitro for the inhibition of murine leukemia P388D1 cell proliferation. [AID225070, Type: confirmatory]
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2
[SID103177124]
ED50 0.001Cytotoxicity against human melanoma RPMI-7951 cell line [AID167041, Type: Literature]
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3
[SID103177124]
ED50 0.001Cytotoxicity against human central nervous system carcinoma TE671 cell line [AID208873, Type: Literature]
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4
[SID103177124]
IC50 0.0011Antiproliferative activity against human HT1080 after 48 hrs by SRB assay [AID627401, Type: Literature]
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5
[SID103177124]
IC50 0.0011Antiproliferative activity against human HT1080 cells after 48 hrs by sulforhodamine B assay [AID605766, Type: Literature]
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6
[SID103177124]
Ki 0.00161Binding affinity to pig brain tubulin [AID711185, Type: Literature]
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7
[SID103177124]
GI50 0.0017Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program [AID247402, Type: Literature]
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8
[SID103177124]
IC50 0.0017Displacement of [3H]colchicine from tubulin by scintillation proximity assay [AID391282, Type: Literature]
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9
[SID103177124]
IC50 0.0018Anti tumor activity on human breast cancer cell line MDR-negative MDA-MB 231 after 72 hours of treatment [AID101630, Type: Literature]
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10
[SID103177124]
IC50 0.00184Cytotoxicity against HeLa cell line [AID277280, Type: Literature]
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11
[SID103177124]
ED50 0.002Cytotoxicity against human solid tumor nasopharyngeal carcinoma KB cell line [AID95523, Type: Literature]
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12
[SID103177124]
IC50 0.0021Antiproliferative activity against human SKOV3 after 48 hrs by SRB assay [AID627403, Type: Literature]
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13
[SID103177124]
IC50 0.0021Antiproliferative activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay [AID605768, Type: Literature]
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14
[SID103177124]
IC50 0.0021Cytotoxicity against human MDA-MB-468 cells assessed as cell viability after 4 days by MTS assay [AID1058421, Type: Literature]
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15
[SID103177124]
IC50 0.0026Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay [AID744714, Type: Literature]
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16
[SID103177124]
IC50 0.00275Cytotoxicity against HCT116 cell line [AID277278, Type: Literature]
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17
[SID103177124]
EC50 0.0028Cell cycle arrest in A431 cells by accumulation at G2/M phase cell [AID256881, Type: Literature]
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18
[SID103177124]
IC50 0.0029Antiproliferative activity against human MDA-MB-231 after 48 hrs by SRB assay [AID627402, Type: Literature]
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19
[SID103177124]
IC50 0.0029Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay [AID605767, Type: Literature]
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20
[SID103177124]
IC50 0.0038Cytotoxicity against human BT474 cells assessed as cell viability after 4 days by MTS assay [AID1058423, Type: Literature]
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