Colchicine (CID 6167) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(953)
 
 
Inactive(1000)
 
 
Inconclusive(262)
 
 
Unspecified(1988)
 
 
Top Targets:
7TM GPCR Srx(30)
 
 
 
p450(29)
 
 
 
 
 
ABC MTABC3 MD..(21)
 
 
 
NR LBD TR(18)
 
 
 
7TM GPCR Srsx(17)
 
 
 
BioAssay Types:
Literature(957)
 
 
 
 
 
Confirmatory(826)
 
 
 
 
 
Screening(355)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(615)
 
 
 
 
 
IC50(539)
 
 
 
 
 
EC50(49)
 
 
 
 
 
Ki(5)
 
 
 
AC50(3)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 3406    Data Row: 4203   Total Pages: 85   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177124]
IC50 0.00062The compound was evaluated in vitro for the inhibition of murine leukemia P388D1 cell proliferation. [AID225070, Type: other]
View
2
[SID103177124]
ED50 0.001Cytotoxicity against human melanoma RPMI-7951 cell line [AID167041, Type: Literature]
View
3
[SID103177124]
ED50 0.001Cytotoxicity against human central nervous system carcinoma TE671 cell line [AID208873, Type: Literature]
View
4
[SID103177124]
IC50 0.0011Antiproliferative activity against human HT1080 cells after 48 hrs by sulforhodamine B assay [AID605766, Type: Literature]
View
5
[SID103177124]
IC50 0.0011Antiproliferative activity against human HT1080 after 48 hrs by SRB assay [AID627401, Type: Literature]
View
6
[SID103177124]
IC50 0.0017Displacement of [3H]colchicine from tubulin by scintillation proximity assay [AID391282, Type: Literature]
View
7
[SID103177124]
GI50 0.0017Growth inhibitory activity against human cancer cell line in the NCI?s anticancer drug screening program [AID247402, Type: Literature]
View
8
[SID103177124]
IC50 0.0018Anti tumor activity on human breast cancer cell line MDR-negative MDA-MB 231 after 72 hours of treatment [AID101630, Type: Literature]
View
9
[SID103177124]
IC50 0.00184Cytotoxicity against HeLa cell line [AID277280, Type: Literature]
View
10
[SID103177124]
ED50 0.002Cytotoxicity against human solid tumor nasopharyngeal carcinoma KB cell line [AID95523, Type: Literature]
View
11
[SID103177124]
IC50 0.0021Antiproliferative activity against human SKOV3 after 48 hrs by SRB assay [AID627403, Type: Literature]
View
12
[SID103177124]
IC50 0.0021Antiproliferative activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay [AID605768, Type: Literature]
View
13
[SID103177124]
IC50 0.00275Cytotoxicity against HCT116 cell line [AID277278, Type: Literature]
View
14
[SID103177124]
EC50 0.0028Cell cycle arrest in A431 cells by accumulation at G2/M phase cell [AID256881, Type: Literature]
View
15
[SID103177124]
IC50 0.0029Antiproliferative activity against human MDA-MB-231 after 48 hrs by SRB assay [AID627402, Type: Literature]
View
16
[SID103177124]
IC50 0.0029Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay [AID605767, Type: Literature]
View
17
[SID103177124]
IC50 0.00399Cytotoxicity against KB-3-1 cell line [AID277281, Type: Literature]
View
18
[SID103177124]
GI50 0.004Growth inhibition of human HT29 cells after 48 hrs [AID288694, Type: Literature]
View
19
[SID103177124]
EC50 0.004Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay [AID312973, Type: Literature]
View
20
[SID103177124]
GI50 0.004Antiproliferative activity against human HT29 cells [AID331396, Type: Literature]
View
21
[SID103177124]
GI50 0.004Growth inhibition of human HT29 cells after 48 hrs by sulforhodamine B assay [AID342492, Type: Literature]
View
22
[SID103177124]
GI50 0.004Antiproliferative activity against human HT29 cells after 48 hrs by sulforhodamine B method [AID342591, Type: Literature]
View
23
[SID49718107]
Potency 0.0046A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
View
24
[SID103177124]
IC50 0.005Growth inhibition of human MCF7 cells after 96 hrs [AID642052, Type: Literature]
View
25
[SID103177124]
IC50 0.005Inhibition of SK-BR-3 cell proliferation [AID201634, Type: Literature]
View
26
[SID103177124]
IC50 0.0052Inhibition of U937 cell proliferation [AID214066, Type: Literature]
View
27
[SID103177124]
IC50 0.0056Inhibition of KB cell proliferation [AID95876, Type: Literature]
View
28
[SID103177124]
IC50 0.006Inhibition of LOVO cell proliferation [AID102187, Type: Literature]
View
29
[SID103177124]
EC50 0.006Tested for caspase activation activity in human breast cancer ZR-75-1 cells [AID220415, Type: Literature]
View
30
[SID103177124]
IC50 0.0063Antiproliferative activity against drug sensitive Messa cell line by Alamar Blue assay [AID280072, Type: Literature]
View
31
[SID103177124]
IC50 0.0064Concentration required to inhibit proliferation of cultured lymphoid leukemia L1210 cells to 50% growth over 48 hours [AID98159, Type: Literature]
View
32
[SID103177124]
IC50 0.0064Concentration that inhibits proliferation of cultured lymphoid leukemia L1210 cells to 50% control growth during 48 h [AID98163, Type: Literature]
View
33
[SID103177124]
IC50 0.0064The compound was tested in vitro for growth of inhibitory activity against lymphoid leukemia L1210 cells [AID93939, Type: Literature]
View
34
[SID103177124]
IC50 0.0064Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay [AID677621, Type: Literature]
View
35
[SID103177124]
IC50 0.0068Antiproliferative activity against human K562 after 48 hrs by SRB assay [AID627396, Type: Literature]
View
36
[SID103177124]
IC50 0.0068Antiproliferative activity against human K562 cells after 48 hrs by sulforhodamine B assay [AID605716, Type: Literature]
View
37
[SID103177124]
IC50 0.0069Antiproliferative activity against mouse L1210 cells after 48 hrs by sulforhodamine B assay [AID605717, Type: Literature]
View
38
[SID103177124]
IC50 0.0069Antiproliferative activity against mouse L1210 after 48 hrs by SRB assay [AID627397, Type: Literature]
View
39
[SID103177124]
IC50 0.0069Inhibition of MDA-MB-468 cell proliferation [AID105060, Type: Literature]
View
40
[SID103177124]
GI50 0.007Growth inhibition of human T47D cells after 48 hrs [AID312974, Type: Literature]
View
41
[SID103177124]
GI50 0.007Growth inhibition of human T47D cells after 48 hrs [AID418789, Type: Literature]
View
42
[SID103177124]
IC50 0.0073Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay [AID597797, Type: Literature]
View
43
[SID103177124]
IC50 0.0073Immunosuppressive activity in LPS-activated B lymphocyte assessed as inhibition of lymphoproliferation after 3 days by beta-scintillation counting [AID428054, Type: Literature]
View
44
[SID103177124]
IC50 0.0079Antiproliferative activity against human CEM cells after 48 hrs by sulforhodamine B assay [AID605769, Type: Literature]
View
45
[SID103177124]
IC50 0.0079Antiproliferative activity against human CEM after 48 hrs by SRB assay [AID627404, Type: Literature]
View
46
[SID103177124]
IC50 0.008Cytotoxicity against human HT-29 cells after 96 hrs using tetracolor one [AID645070, Type: other]
View
47
[SID103177124]
IC50 0.008Cytotoxicity against human HT-29 cells [AID661637, Type: Literature]
View
48
[SID103177124]
IC50 0.008Antiproliferative activity against human U937 cells by sulforhodamine B assay [AID473624, Type: Literature]
View
49
[SID103177124]
EC50 0.009Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay [AID312971, Type: Literature]
View
50
[SID103177124]
GI50 0.009Antiproliferative activity against human MCF7 cells [AID331398, Type: Literature]
View