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Colchicine (CID 6167) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1212)
 
 
Inactive(1261)
 
 
Inconclusive(364)
 
 
Unspecified(2060)
 
 
Top Targets:
beta tubulin(84)
 
 
 
7TM GPCR Srx(45)
 
 
 
 
alpha tubulin(43)
 
 
 
NR LBD PPAR(39)
 
 
 
p450(34)
 
 
 
 
 
BioAssay Types:
Literature(1242)
 
 
 
 
 
Confirmatory(1101)
 
 
 
 
 
Screening(413)
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
Potency(933)
 
 
 
 
 
IC50(717)
 
 
 
 
 
EC50(49)
 
 
 
 
 
Ki(7)
 
 
 
AC50(5)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 3696    Data Row: 4897   Total Pages: 98   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177124]
IC50 0.00062The compound was evaluated in vitro for the inhibition of murine leukemia P388D1 cell proliferation. [AID225070, Type: other]
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2
[SID103177124]
ED50 0.001Cytotoxicity against human melanoma RPMI-7951 cell line [AID167041, Type: Literature]
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3
[SID103177124]
ED50 0.001Cytotoxicity against human central nervous system carcinoma TE671 cell line [AID208873, Type: Literature]
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4
[SID103177124]
IC50 0.0011Antiproliferative activity against human HT1080 cells after 48 hrs by sulforhodamine B assay [AID605766, Type: Literature]
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5
[SID103177124]
IC50 0.0011Antiproliferative activity against human HT1080 after 48 hrs by SRB assay [AID627401, Type: Literature]
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6
[SID103177124]
Ki 0.00161Binding affinity to pig brain tubulin [AID711185, Type: Literature]
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7
[SID103177124]
GI50 0.0017Growth inhibitory activity against human cancer cell line in the NCI inverted question marks anticancer drug screening program [AID247402, Type: Literature]
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8
[SID103177124]
IC50 0.0017Displacement of [3H]colchicine from tubulin by scintillation proximity assay [AID391282, Type: Literature]
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9
[SID103177124]
IC50 0.0018Anti tumor activity on human breast cancer cell line MDR-negative MDA-MB 231 after 72 hours of treatment [AID101630, Type: Literature]
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10
[SID103177124]
IC50 0.00184Cytotoxicity against HeLa cell line [AID277280, Type: Literature]
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11
[SID103177124]
ED50 0.002Cytotoxicity against human solid tumor nasopharyngeal carcinoma KB cell line [AID95523, Type: Literature]
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12
[SID103177124]
IC50 0.0021Antiproliferative activity against human SKOV3 after 48 hrs by SRB assay [AID627403, Type: Literature]
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13
[SID103177124]
IC50 0.0021Antiproliferative activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay [AID605768, Type: Literature]
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14
[SID103177124]
IC50 0.00275Cytotoxicity against HCT116 cell line [AID277278, Type: Literature]
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15
[SID103177124]
EC50 0.0028Cell cycle arrest in A431 cells by accumulation at G2/M phase cell [AID256881, Type: Literature]
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16
[SID103177124]
IC50 0.0029Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay [AID605767, Type: Literature]
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17
[SID103177124]
IC50 0.0029Antiproliferative activity against human MDA-MB-231 after 48 hrs by SRB assay [AID627402, Type: Literature]
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18
[SID103177124]
IC50 0.00399Cytotoxicity against KB-3-1 cell line [AID277281, Type: Literature]
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19
[SID103177124]
GI50 0.004Growth inhibition of human HT29 cells after 48 hrs [AID288694, Type: Literature]
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20
[SID103177124]
EC50 0.004Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay [AID312973, Type: Literature]
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21
[SID103177124]
GI50 0.004Antiproliferative activity against human HT29 cells [AID331396, Type: Literature]
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22
[SID103177124]
GI50 0.004Growth inhibition of human HT29 cells after 48 hrs by sulforhodamine B assay [AID342492, Type: Literature]
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23
[SID103177124]
GI50 0.004Antiproliferative activity against human HT29 cells after 48 hrs by sulforhodamine B method [AID342591, Type: Literature]
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24
[SID49718107]
Potency 0.0046A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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25
[SID103177124]
IC50 0.005Growth inhibition of human MCF7 cells after 96 hrs [AID642052, Type: Literature]
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26
[SID103177124]
IC50 0.005Cytotoxicity against human MCF7 cells assessed as growth inhibition by trypan blue exclusion assay [AID721884, Type: Literature]
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27
[SID103177124]
IC50 0.005Inhibition of SK-BR-3 cell proliferation [AID201634, Type: Literature]
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28
[SID103177124]
IC50 0.0052Inhibition of U937 cell proliferation [AID214066, Type: Literature]
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29
[SID103177124]
IC50 0.0056Inhibition of KB cell proliferation [AID95876, Type: Literature]
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30
[SID103177124]
IC50 0.006Inhibition of LOVO cell proliferation [AID102187, Type: Literature]
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31
[SID103177124]
EC50 0.006Tested for caspase activation activity in human breast cancer ZR-75-1 cells [AID220415, Type: Literature]
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32
[SID103177124]
IC50 0.0063Antiproliferative activity against drug sensitive Messa cell line by Alamar Blue assay [AID280072, Type: Literature]
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33
[SID103177124]
IC50 0.0064Concentration required to inhibit proliferation of cultured lymphoid leukemia L1210 cells to 50% growth over 48 hours [AID98159, Type: Literature]
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34
[SID103177124]
IC50 0.0064Concentration that inhibits proliferation of cultured lymphoid leukemia L1210 cells to 50% control growth during 48 h [AID98163, Type: Literature]
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35
[SID103177124]
IC50 0.0064The compound was tested in vitro for growth of inhibitory activity against lymphoid leukemia L1210 cells [AID93939, Type: Literature]
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36
[SID103177124]
IC50 0.0064Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay [AID677621, Type: Literature]
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37
[SID103177124]
IC50 0.0067Cytotoxicity against human SW780 cells after 96 hrs by MTT assay [AID711175, Type: Literature]
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38
[SID103177124]
IC50 0.0068Antiproliferative activity against human K562 after 48 hrs by SRB assay [AID627396, Type: Literature]
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39
[SID103177124]
IC50 0.0068Antiproliferative activity against human K562 cells after 48 hrs by sulforhodamine B assay [AID605716, Type: Literature]
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40
[SID103177124]
IC50 0.0069Antiproliferative activity against mouse L1210 cells after 48 hrs by sulforhodamine B assay [AID605717, Type: Literature]
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41
[SID103177124]
IC50 0.0069Antiproliferative activity against mouse L1210 after 48 hrs by SRB assay [AID627397, Type: Literature]
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42
[SID103177124]
IC50 0.0069Inhibition of MDA-MB-468 cell proliferation [AID105060, Type: Literature]
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43
[SID103177124]
GI50 0.007Growth inhibition of human T47D cells after 48 hrs [AID312974, Type: Literature]
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44
[SID103177124]
GI50 0.007Growth inhibition of human T47D cells after 48 hrs [AID418789, Type: Literature]
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45
[SID103177124]
IC50 0.0073Immunosuppressive activity in LPS-activated B lymphocyte assessed as inhibition of lymphoproliferation after 3 days by beta-scintillation counting [AID428054, Type: Literature]
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46
[SID103177124]
IC50 0.0073Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay [AID597797, Type: Literature]
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47
[SID103177124]
IC50 0.0076Antiproliferative activity against quesicent HUVECs after 48 hrs by CCK-8 assay [AID730202, Type: Literature]
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48
[SID144210899]
Potency-Replicate_1 0.0077qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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49
[SID144210899]
Potency-Replicate_1 0.0077qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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50
[SID144210899]
Potency-Replicate_1 0.0077qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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