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BioActivity Data for Compound Phenylalanine (CID 6140)

BioActivity Outcomes:
Active(81)
 
 
Inactive(261)
 
 
Inconclusive(7)
 
 
Unspecified(78)
 
 
Top Targets:
alpha CA I II..(18)
 
 
 
alpha CA(14)
 
 
 
p450(11)
 
 
NR LBD TR(6)
 
 
 
HSD10-like SD..(6)
 
 
BioAssay Types:
Literature(213)
 
 
 
 
Confirmatory(183)
 
 
 
 
Screening(4)
 
 
BioAssay Categories:
In vitro(7)
 
 
In vivo(1)
 
 
Biochemical(72)
 
 
 
 
 
Toxicity(17)
 
 
 
ADME(19)
 
 
 
Cell-based(11)
 
 
 
BioActivity Types:
Potency(155)
 
 
 
 
Ki(5)
 
 
 
IC50(3)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 308    Data Row: 427   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID46393329]
Kd 0.18Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain C, L-Leucine-Binding Protein With Phenylalanine Bound [gi:413915680]
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2
[SID26753740]
Potency 11.2202qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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3
[SID124877010]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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4
[SID46391851]
Ki 12700Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of The Streptomyces Griseus Aminopeptidase Complexed With L-Phenylalanine [gi:15826677]
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5
[SID46391851]
Ki 12700Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of The Streptomyces Griseus Aminopeptidase Complexed With L-Phenylalanine [gi:15826677]
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6
[SID103241518]
Activation of Candida glabrata recombinant carbonic anhydrase by stopped flow CO2 hydration method [AID464322, Type: Literature]Similar to sp|P53615 Saccharomyces cerevisiae YNL036w NCE3 [gi:74610182]
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7
[SID103241518]
Activation of Candida albicans beta-carbonic anhydrase Nce103 by stopped flow CO2 hydration assay [AID458784, Type: Literature]Carbonic anhydrase [gi:74656605]
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8
[SID103241518]
Activation of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method [AID318345, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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9
[SID103241518]
Activation of human recombinant CA6 by stopped flow CO2 hydrase method [AID307898, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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10
[SID103241518]
Activation of human full length CA6 by stopped flow CO2 hydration assay [AID462831, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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11
[SID46391851]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of The Streptomyces Griseus Aminopeptidase Complexed With L-Phenylalanine [gi:15826677]
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12
[SID103241518]
Activation of human recombinant CA3 at 10 uM by stopped-flow CO2 hydration method [AID365829, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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13
[SID103241518]
Activation of human recombinant CA3 by stopped-flow CO2 hydrase assay [AID409993, Type: Literature]Carbonic anhydrase 3 [gi:134047703]
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14
[SID46393329]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: other]Chain C, L-Leucine-Binding Protein With Phenylalanine Bound [gi:157880428]
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15
[SID103241518]
Activation of Cryptococcus neoformans beta-carbonic anhydrase Can2 by stopped flow CO2 hydration assay [AID458787, Type: Literature]
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16
[SID103241518]
Activation of Stylophora pistillata carbonic anhydrase STPCA by stopped flow CO2 hydration assay [AID462832, Type: Literature]
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17
[SID103241518]
Activity of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant CA expressed in Escherichia coli BL21(DE3) after 15 mins by phenol red staining based stopped flow CO2 hydration assay [AID691715, Type: Literature]
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18
[SID103241518]
Binding affinity to FITC-tagged LPS assessed as induction of disintegration up to 40 uM by circular dichroism analysis [AID722294, Type: Literature]
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19
[SID103241518]
Binding affinity to LPS assessed as increase in helical structure at 36 uM by circular dichroism analysis [AID722295, Type: Literature]
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20
[SID103241518]
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL6 secretion at 1.5 to 4.5 uM after 12 hrs by ELISA [AID722296, Type: Literature]
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