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Phenylalanine (CID 6140) - Compound BioActivity Data
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BioActivity Outcomes:
Active(79)
 
 
Inactive(260)
 
 
Inconclusive(7)
 
 
Unspecified(76)
 
 
Top Targets:
alpha CA I II..(31)
 
 
 
p450(11)
 
 
NR LBD TR(6)
 
 
 
HSD10-like SD..(6)
 
 
NR LBD PPAR(5)
 
 
 
BioAssay Types:
Literature(207)
 
 
 
 
Confirmatory(183)
 
 
 
 
Screening(4)
 
 
BioActivity Types:
Potency(155)
 
 
 
 
Ki(3)
 
 
 
IC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 304    Data Row: 422   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103241518]
Ki 0.98Displacement of [3H]L-leucine from alpha-2delta containing calcium channel in murine brain [AID261154, Type: Literature]Voltage-dependent calcium channel subunit alpha-2/delta-1 [gi:46576352]
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2
[SID103241518]
MIC 3Antifungal activity against Aspergillus fumigatus after 72 hrs by NCCLS microbroth dilution method [AID722315, Type: Literature]
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3
[SID103241518]
MIC 3Antifungal activity against Trichophyton mentagrophytes after 96 hrs by NCCLS microbroth dilution method [AID722316, Type: Literature]
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4
[SID103241518]
MIC 3Antifungal activity against Sporothrix schenckii after 72 hrs by NCCLS microbroth dilution method [AID722317, Type: Literature]
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5
[SID103241518]
MIC 3Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by NCCLS microbroth dilution method [AID722318, Type: Literature]
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6
[SID103241518]
MIC 3.1Antifungal activity against Candida albicans after 48 hrs by NCCLS microbroth dilution method [AID722320, Type: Literature]
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7
[SID103241518]
MIC 6Antibacterial activity against Klebsiella pneumoniae ATCC 27736 after 18 hrs by broth dilution method [AID722321, Type: Literature]
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8
[SID103241518]
MIC 6Antibacterial activity against Escherichia coli ATCC 10536 after 18 hrs by broth dilution method [AID722324, Type: Literature]
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9
[SID103241518]
MIC 6.1Antifungal activity against Cryptococcus neoformans after 72 hrs by NCCLS microbroth dilution method [AID722319, Type: Literature]
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10
[SID103241518]
MIC 6.25Antibacterial activity against Staphylococcus aureus ATCC 9144 after 18 hrs by broth dilution method [AID722327, Type: Literature]
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11
[SID26753740]
Potency 11.2202qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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12
[SID103241518]
MIC 11.3Antibacterial activity against Bacillus subtilis ATCC 6633 after 18 hrs by broth dilution method [AID722325, Type: Literature]
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13
[SID103241518]
MIC 13.2Antibacterial activity against Staphylococcus epidermidis NRRL B-4268 after 18 hrs by broth dilution method [AID722326, Type: Literature]
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14
[SID103241518]
MIC 25Antibacterial activity against Pseudomonas aeruginosa ATCC BAA-427 after 18 hrs by broth dilution method [AID722322, Type: Literature]
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15
[SID103241518]
MIC 25Antibacterial activity against methicillin-resistant Staphylococcus aureus after 18 hrs by broth dilution method [AID722323, Type: Literature]
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16
[SID124877010]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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17
[SID46391851]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of The Streptomyces Griseus Aminopeptidase Complexed With L-Phenylalanine [gi:15826677]
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18
[SID103241518]
Activation of membrane associated mouse recombinant carbonic anhydrase 15 isoform by stopped-flow CO2 hydrase method [AID375787, Type: Literature]Carbonic anhydrase 15 [gi:30580362]
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19
[SID103241518]
Activation of mouse recombinant CA13 by CO2 hydrase method [AID268622, Type: Literature]Carbonic anhydrase 13 [gi:30580372]
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20
[SID103241518]
Activation of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method [AID318345, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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21
[SID103241518]
Activation of human recombinant CA6 by stopped flow CO2 hydrase method [AID307898, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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22
[SID103241518]
Activation of human full length CA6 by stopped flow CO2 hydration assay [AID462831, Type: Literature]Carbonic anhydrase 6 [gi:116241278]
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23
[SID103241518]
Activity of human recombinant CA1 cytosolic isoform after 15 mins by phenol red staining based stopped flow CO2 hydration assay [AID691713, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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24
[SID103241518]
Activation of human recombinant CA1 by CO2 hydrase assay [AID291061, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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25
[SID103241518]
Activation of human recombinant CA1 by CO2 hydrase assay [AID268620, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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26
[SID103241518]
Activation of human recombinant CA1 by stopped flow CO2 hydrase method [AID307896, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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27
[SID103241518]
Activation of human recombinant CA2 by stopped flow CO2 hydrase method [AID307897, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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28
[SID103241518]
Activation of human recombinant CA2 by CO2 hydrase assay [AID268621, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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29
[SID103241518]
Activation of human recombinant CA2 by stopped-flow CO2 hydration method [AID318344, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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30
[SID103241518]
Activation of human recombinant CA2 at 10 uM by stopped-flow CO2 hydration method [AID365828, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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31
[SID103241518]
Activation of human recombinant CA2 by stopped-flow CO2 hydrase assay [AID409986, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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32
[SID103241518]
Activation of human recombinant CA2 by stopped-flow CO2 hydrase method [AID414329, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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33
[SID103241518]
Activation of human recombinant CA2by stopped flow CO2 hydration assay [AID462830, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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34
[SID103241518]
Activation of human recombinant carbonic anhydrase isoenzyme 2 by stopped flow CO2 hydration method [AID464319, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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35
[SID103241518]
Activation of human recombinant CA2 by stopped flow CO2 hydrase method [AID725229, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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36
[SID103241518]
Activity of human recombinant CA2 cytosolic isoform after 15 mins by phenol red staining based stopped flow CO2 hydration assay [AID691714, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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37
[SID103241518]
Activation of human recombinant truncated CA4 at 10 uM by stopped-flow CO2 hydration method [AID365830, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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38
[SID103241518]
Activation of human recombinant carbonic anhydrase 4 lacking 20 aminoterminal residues by stopped-flow CO2 hydrase method [AID375786, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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39
[SID103241518]
Activation constant against recombinant human CA IV isozyme by the esterase method [AID257047, Type: Literature]Carbonic anhydrase 4 [gi:115465]
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40
[SID103241518]
Activation of human recombinant CA2 by CO2 hydrase assay [AID291063, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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41
[SID103241518]
Activation of human recombinant carbonic anhydrase 5A by stopped-flow CO2 hydrase method [AID305776, Type: Literature]Carbonic anhydrase 5A, mitochondrial [gi:461680]
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42
[SID103241518]
Drug uptake in Escherichia coli ATCC 10536 assessed as membrane localization at 3 uM after 30 mins by confocal microscopic analysis [AID722314, Type: Literature]
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43
[SID103241518]
Activation of human recombinant CA7 by CO2 hydrase assay [AID291065, Type: Literature]Carbonic anhydrase 7 [gi:1168744]
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44
[SID103241518]
Activation of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method [AID318346, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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45
[SID103241518]
Activation of of human recombinant CA14 by CO2 hydrase assay [AID291067, Type: Literature]Carbonic anhydrase 14 [gi:8928036]
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46
[SID103241518]
Activation of human recombinant carbonic anhydrase 5B by stopped-flow CO2 hydrase method [AID305777, Type: Literature]Carbonic anhydrase 5B, mitochondrial [gi:8928041]
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47
[SID103241518]
Bactericidal activity against Escherichia coli ATCC 10536 assessed as induction of membrane damage at 5 uM after 30 mins by propidium iodide staining-based flow cytometric analysis [AID722312, Type: Literature]
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48
[SID103241518]
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha secretion at 1.5 to 4.5 uM after 12 hrs by ELISA [AID722330, Type: Literature]
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49
[SID103241518]
Drug uptake in human RBC assessed as membrane localization at 9 uM after 10 to 30 mins by confocal microscopic analysis [AID722331, Type: Literature]
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50
[SID103241518]
Activation of Sulfurihydrogenibium azorense recombinant alpha carbonic anhydrase by stopped flow CO2 hydrase method [AID725226, Type: Literature]
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