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Methionine (CID 6137) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inconclusive(4)
 
 
Unspecified(24)
 
 
Top Targets:
LuxS(3)
 
 
 
MetRS core(1)
 
 
MFS(1)
 
 
MetAP2(1)
 
 
M28 SGAP like(1)
 
 
BioAssay Types:
Literature(32)
 
 
 
 
BioActivity Types:
Ki(8)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 32    Data Row: 34   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103222496]
Km 5Michaelis constant (KM) was evaluated [AID17451, Type: Literature]
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2
[SID103222496]
Km 5Substrate activity with rat Methionine adenosyltransferase II [AID107897, Type: Literature]
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3
[SID103222496]
Km 15.6Substrate activity with normal tissue (M-T) form of rat methionine Adenosyltransferase [AID34131, Type: Literature]
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4
[SID46393022]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Streptomyces Griseus Aminopeptidase Complexed With Methionine [gi:7766866]
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5
[SID46392872]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Methionyl-Trna Synthetase From Escherichia Coli Complexed With Methionine And Adenosine [gi:46015206]
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6
[SID46393499]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, The Product Bound Form Of The Mn(Ii)loaded Methionine Aminopeptidase From Hyperthermophile Pyrococcus Furiosus [gi:61680215]
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7
[SID103222496]
Ki 61Inhibition of cobalt substituted Bacillus subtilis LuxS [AID264583, Type: Literature]S-ribosylhomocysteine lyase [gi:7387851]
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8
[SID103222496]
Km 70Compound was evaluated for its inhibitory activity against recombinant S-adenosyl L-Methionine synthetase (alpha-isoform) in rat liver [AID200229, Type: Literature]
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9
[SID103222496]
EC50 800Concentration required for obtaining 50% of the fluorescence intensity of copper-free calcein 1, in bovine serum albumin [AID51033, Type: Literature]
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10
[SID103222496]
Km 2600Effect on Salinispora tropica CNB-440 wild type recombinant SalL expressed in Escherichia coli BL21(DE3)-mediated S-Adenosyl methionine formation after 30 mins by HPLC analysis [AID498933, Type: Literature]
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11
[SID103222496]
Ki 26900Compound tested for the inhibition of Gamma-glutamyltranspeptidase in rat kidney at pH 8.0 at 37 degree C (Competitive inhibition) [AID71712, Type: Literature]
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12
[SID103222496]
Ki 150000Inhibition constant against Escherichia coli cyclopropane fatty acid synthase [AID71601, Type: Literature]
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13
[SID103222496]
Calculated partition coefficient (clogP) [AID16315, Type: other]
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14
[SID103222496]
Substrate level that produces half the maximal velocity(M-T) of rat methionine adenosyl transferase [AID34138, Type: Literature]
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15
[SID103222496]
Partition coefficient (logP) [AID26797, Type: Literature]
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16
[SID103222496]
Ratio of relative Vmax of normal tissue (M-2) form of rat methionine Adenosyltransferase to that of KM of normal tissue(M-2)form of rat methionine Adenosyltransferase [AID230503, Type: Literature]
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17
[SID103222496]
Ratio of Vmax of normal tissue (M-T) form of rat methionine Adenosyltransferase to that of KM of normal tissue(M-T)form of rat methionine Adenosyltransferase [AID230665, Type: Literature]
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18
[SID103222496]
Bitter threshold value of the compound; S denotes 'Sulfurous' [AID233322, Type: Literature]
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19
[SID103222496]
Antihepatotoxic activity against 1.5 hrs galactosamine pretreatment-induced cytotoxicity in Wistar rat hepatocytes assessed as glutamic-pyruvic transaminase activity at 0.01 mg/ml after 30 hrs relative to control [AID401471, Type: Literature]
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20
[SID103222496]
Antihepatotoxic activity against 1.5 hrs galactosamine pretreatment-induced cytotoxicity in Wistar rat hepatocytes assessed as glutamic-pyruvic transaminase activity at 0.1 mg/ml after 30 hrs relative to control [AID401472, Type: Literature]
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21
[SID103222496]
Antihepatotoxic activity against 1.5 hrs galactosamine pretreatment-induced cytotoxicity in Wistar rat hepatocytes assessed as glutamic-pyruvic transaminase activity at 1 mg/ml after 30 hrs relative to control [AID401473, Type: Literature]
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22
[SID103222496]
Cytotoxicity in Wistar rat hepatocytes assessed as glutamic-pyruvic transaminase activity at 0.01 mg/ml after 30 hrs [AID401474, Type: Literature]
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23
[SID103222496]
Cytotoxicity in Wistar rat hepatocytes assessed as glutamic-pyruvic transaminase activity at 0.1 mg/ml after 30 hrs [AID401475, Type: Literature]
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24
[SID103222496]
Cytotoxicity in Wistar rat hepatocytes assessed as glutamic-pyruvic transaminase activity at 1 mg/ml after 30 hrs [AID401476, Type: Literature]
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25
[SID103222496]
Activity at Salinispora tropica CNB-440 wild type recombinant SalL expressed in Escherichia coli BL21(DE3) assessed as formation of S-Adenosyl methionine after 30 mins by HPLC analysis [AID498932, Type: Literature]
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26
[SID103222496]
Ratio of Kcat to Km for Salinispora tropica CNB-440 wild type recombinant SalL expressed in Escherichia coli BL21(DE3) for formation of S-Adenosyl methionine [AID498934, Type: Literature]
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27
[SID103222496]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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28
[SID103222496]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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29
[SID103222496]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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30
[SID103222496]
Ki TP_TRANSPORTER: inhibition of L-tryptophan uptake in Xenopus laevis oocytes [AID681113, Type: other]Monocarboxylate transporter 10 [gi:81871541]
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31
[SID103222496]
Ki Inhibition of cobalt substituted Escherichia coli LuxS [AID264584, Type: Literature]
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32
[SID103222496]
Ki Inhibition of cobalt substituted Vibrio harveyi LuxS [AID264585, Type: Literature]
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33
[SID103222496]
Ki Inhibition of ferrous substituted Bacillus subtilis LuxS [AID264586, Type: Literature]S-ribosylhomocysteine lyase [gi:7387851]
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34
[SID103222496]
Ki Inhibition of zinc substituted Bacillus subtilis LuxS [AID264587, Type: Literature]S-ribosylhomocysteine lyase [gi:7387851]
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